INTERLEUKIN-22 POLYPEPTIDES, NUCLEIC ACIDS ENCODING THE SAME AND METHODS FOR THE TREATMENT OF PANCREATIC DISORDERS
The present invention is directed to interleukin-22 polypeptides and nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
1 . A method for alleviating a pancreatic disorder in a mammal comprising administering to said mammal a therapeutically effective amount of an anti-IL-22 antibody.
2 . The method of claim 1 wherein the mammal is a human.
3 . The method of claim 2 wherein the pancreatic disorder is acute pancreatic, chronic pancreatic, pancreatic carcinoma, or pancreatic inflammation.
4 . The method of claim 3 wherein the pancreatic carcinoma is acinar cell carcinoma or mixed cell population pancreatic cell carcinoma.