Substrates containing polyphosphazene as matrices and substrates containing polyphosphazene with a micro-structured surface
View Patent ↗This disclosure relates to substrates containing at least one polyphosphazene with a forming surface as matrices for producing biological materials that can be implanted in a mammal. The disclosure also relates to a method for producing such substrates and substrates containing polyphosphazene with a micro-structured surface.
1. A substrate comprising a polyphosphazene micro-structured surface, wherein:
a) the polyphosphazene micro-structured substrate has a polyphosphazene film thickness from 65 nm to 290 nm;
b) the spacing density of the void structure within the polyphosphazene micro-structured substrate is from 650 voids per 100 μm 2 to 100 voids/100 μm 2 ; and
c) the surface coverage of the polyphosphazene micro-structured substrate is from 92.5% to 97.5%, and
d) the polyphosphazene is present in the polyphosphazene film at a concentration from about 6 mg/mL to about 20 mg/mL,
wherein the substrate is selected from the group consisting of a polymer, a copolymer, a rubber material, an elastomer, an elastomeric membrane, a fabric, a polysaccharide, a glass, and combinations thereof, and
wherein the substrate exhibits cellular replusion.