GH secretagogues and uses thereof
View Patent ↗The invention relates to use of a GH secretagogue (e.g. GRF or an analog thereof) for (1) altering a lipid parameter in a subject; (2) altering a body composition parameter in a subject, (3) treating a condition characterized by deficient or decreased bone formation in a subject (4) improving daytime vigilance and/or cognitive function in a subject, (5) improving a metabolic condition in a subject, (6) improving anabolism in a catabolic condition in a subject, and/or (7) improving and/or reconstituting immune function in a subject.
1. A method of improving cognitive function in a subject suffering from mild cognitive impairment, said method comprising administering to said subject:
(a) (hexenoyl trans-3)hGRF(1-44)NH 2 ; or
(b) a composition comprising (hexenoyl trans-3)hGRF(1-44)NH 2 and a pharmaceutically acceptable carrier.
2. The method of claim 1 , wherein said cognitive function is thinking, reasoning, problem solving or memory.
3. The method of claim 1 , wherein said (hexenoyl trans-3)hGRF(1-44)NH 2 is administered at a dose of about 0.0001 to 2 mg.
4. The method of claim 3 , wherein said (hexenoyl trans-3)hGRF(1-44)NH 2 is administered at a dose of about 0.1 mg or about 1 mg.
5. The method of claim 4 , wherein said (hexenoyl trans-3)hGRF(1-44)NH 2 is administered at a dose of about 1 mg.
6. The method of claim 1 , wherein said (hexenoyl trans-3)hGRF(1-44)NH 2 or said composition is administered by an intravenous, oral, transdermal, subcutaneous, mucosal, intramuscular, intranasal, intrapulmonary, parenteral, intrarectal or topical route.
7. The method of claim 6 , wherein said (hexenoyl trans-3)hGRF(1-44)NH 2 or said composition is administered by a subcutaneous route.