IP Library Granted Patent US 8,206,315
Granted Patent B2
US 8,206,315 · App. 12/241,644 · Granted Jun 26, 2012

Real-time pathology

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Quick Facts
Patent No.
US 8,206,315
App. No.
12/241,644
Granted
Jun 26, 2012
Kind
B2
Abstract

A system for detecting abnormal tissue in a patient including an introducer cannula having a proximal opening and a distal opening. The system further includes a surgical instrument configured for selective insertion through the cannula. The surgical instrument further includes a tissue cutting opening positioned relative to the distal end of the introducer cannula when fully inserted through the introducer cannula. The system also includes a sensor configured to detect at least one property of the tissue of the patient. The sensor is located at a fixed distance relative to the distal end of the introducer cannula when the surgical instrument is inserted into the introducer cannula.

Claims (54)

1. A system for detecting tissue in a patient comprising:

a surgical instrument configured for selective insertion into a patient, the surgical instrument further comprising an outer cannula having a tissue sampling aperture positioned adjacent a distal end of the outer cannula;

an inner cutting cannula positioned within the outer cannula, the inner cutting cannula including a cutting edge selectively moveable across the tissue sampling aperture to sever tissue; and

a sensor configured to detect at least one property of the tissue of said patient, the sensor fixedly attached to an inner surface of the outer cannula so as to contact tissue prolapsed through the sampling aperture, wherein the inner surface of the outer cannula to which the sensor is attached is oriented axially relative to a longitudinal axis of the outer cannula, and is positioned between the tissue sampling aperture and the distal end of the outer cannula.

2. The system of claim 1 , wherein the sensor is positioned opposite the cutting edge of the inner cutting cannula and at a perpendicular distance from a longitudinal axis of the inner cannula not greater than a maximum radial dimension of the inner cannula.

3. The system of claim 1 , further comprising an introducer cannula having a proximal opening and a distal opening, wherein the outer cannula is inserted into the introducer cannula prior to selective insertion into a patient.

4. The system of claim 3 , wherein the sensor is selectively rotatable relative to the introducer cannula.

5. The system of claim 1 , further comprising a vacuum source that delivers vacuum adjacent the sensor.

6. The system of claim 1 , wherein the surgical instrument is a tissue resection device.

7. The system of claim 1 , wherein the sensor is located adjacent the sampling aperture.

8. The system of claim 1 , further comprising a processor electrically communicating with the sensor, the processor analyzing data from the sensor.

9. The system of claim 1 , further comprising an indicator.

10. The system of claim 9 , wherein the indicator indicates to a user an abnormality of the tissue of the patient.

11. The system of claim 9 , wherein the indicator indicates to a user a normality of the tissue of the patient.

12. The system of claim 1 , further comprising a tissue collection filter that is configured to retain resected tissue therein, a vacuum source being operatively connected to the tissue collection filter to draw resected tissue into the tissue collection filter.

13. A system for detecting tissue in a patient comprising:

a surgical instrument configured for selective insertion into a patient, the surgical instrument further comprising an outer cannula having a tissue sampling aperture positioned adjacent a distal end of the outer cannula;

an inner cutting cannula positioned within the outer cannula, the inner cutting cannula including a cutting edge selectively moveable across the tissue sampling aperture to sever tissue; and

a sensor configured to detect at least one property of the tissue of said patient, the sensor fixedly attached to an inner surface of the outer cannula so as to contact tissue prolapsed through the sampling aperture, wherein the inner surface of the outer cannula to which the sensor is attached is oriented substantially perpendicular to a longitudinal axis of the inner cutting cannula.

14. The system of claim 13 , wherein the sensor and the tissue sampling aperture are generally arranged along a common plane oriented substantially perpendicular to a longitudinal axis of the outer cannula.

15. The system of claim 13 , further comprising an introducer cannula having a proximal opening and a distal opening, wherein the outer cannula is inserted into the introducer cannula prior to selective insertion into a patient.

16. The system of claim 15 , wherein the sensor is selectively rotatable relative to the introducer cannula.

17. The system of claim 13 , further comprising a vacuum source that delivers vacuum adjacent the sensor.

18. The system of claim 13 , wherein the surgical instrument is a tissue resection device.

19. The system of claim 13 , further comprising a processor electrically communicating with the sensor, the processor analyzing data from the sensor.

20. The system of claim 13 , further comprising an indicator.

21. The system of claim 20 , wherein the indicator indicates to a user an abnormality of the tissue of the patient.

22. The system of claim 20 , wherein the indicator indicates to a user a normality of the tissue of the patient.

23. The system of claim 13 , further comprising a tissue collection filter that is configured to retain resected tissue therein, a vacuum source being operatively connected to the tissue collection filter to draw resected tissue into the tissue collection filter.

24. A system for detecting tissue in a patient comprising:

a surgical instrument configured for selective insertion into a patient, the surgical instrument further comprising an outer cannula having a tissue sampling aperture positioned adjacent a distal end of the outer cannula;

an inner cutting cannula positioned within the outer cannula, the inner cutting cannula including a cutting edge selectively moveable across the tissue sampling aperture to sever tissue; and

a sensor configured to detect at least one property of the tissue of said patient, the sensor fixedly attached to an inner surface of the outer cannula so as to contact tissue prolapsed through the sampling aperture, wherein the inner surface of the outer cannula to which the sensor is attached is oriented at an oblique angle relative to a longitudinal axis of the inner cutting cannula.

25. The system of claim 24 , wherein the sensor is positioned on an inner surface of the outer cannula that intersects the longitudinal axis of the inner cutting cannula.

26. The system of claim 24 , further comprising an introducer cannula having a proximal opening and a distal opening, wherein the outer cannula is inserted into the introducer cannula prior to selective insertion into a patient.

27. The system of claim 26 , wherein the sensor is selectively rotatable relative to the introducer cannula.

28. The system of claim 24 , further comprising a vacuum source that delivers vacuum adjacent the sensor.

29. The system of claim 24 , wherein the surgical instrument is a tissue resection device.

30. The system of claim 24 , further comprising a processor electrically communicating with the sensor, the processor analyzing data from the sensor.

31. The system of claim 24 , further comprising an indicator.

32. The system of claim 31 , wherein the indicator indicates to a user an abnormality of the tissue of the patient.

33. The system of claim 31 , wherein the indicator indicates to a user a normality of the tissue of the patient.

34. The system of claim 24 , further comprising a tissue collection filter that is configured to retain resected tissue therein, a vacuum source being operatively connected to the tissue collection filter to draw resected tissue into the tissue collection filter.

35. The system of claim 24 , wherein the sensor is fixedly attached to the inner cutting cannula for concurrent movement therewith.

36. A system for detecting a characteristic of tissue in a patient comprising:

an outer cannula having a tissue sampling aperture positioned adjacent a distal end of the outer cannula;

an inner cutting cannula positioned within the outer cannula, the inner cutting cannula including a cutting edge selectively moveable across the tissue sampling aperture to sever tissue, and a lumen at least partially defining a fluid path for transporting the severed tissue away from the sampling aperture; and

a sensor configured to detect abnormal tissue of the patient, the sensor positioned within the fluid path and the lumen.

37. The system of claim 36 , wherein the inner cutting cannula includes a first end defined by the cutting edge, and an opposite second end, the sensor arranged within the inner cutting cannula between the first end and the second end.

38. The system of claim 36 further comprising a tissue collection filter configured to retain the resected tissue, the filter disposed within the fluid path, wherein the inner cutting cannula includes a first end defined by the cutting edge, and an opposite second end, the sensor being positioned within the fluid path between the first end and the tissue collection filter, and the second end and the tissue collection filter.

39. The system of claim 36 , wherein the lumen at least partially defines an inner surface of the inner cutting cannula, the sensor being attached to the inner surface.

40. The system of claim 36 , wherein the sensor is fixedly attached to the inner cutting cannula for concurrent movement therewith.

41. The system of claim 36 , further comprising a processor electrically communicating with the sensor, said processor analyzing data from the sensor.

42. The system of claim 36 , further comprising an indicator related to a determination of abnormality of the tissue.

Assignments (10)
RELEASE OF SECURITY INTEREST Recorded Apr 28, 2026
From: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
To: HOLOGIC, INC., ON ITS OWN BEHALF AND AS SUCCESSOR-BY-MERGER TO DIRECT RADIOGRAPHY CORP.; CYTYC CORPORATION, ON ITS OWN BEHALF AND AS SUCCESSOR-BY-MERGER TO BIOLUCENT, LLC; CYTYC SURGICAL PRODUCTS, LLC, AS SUCCESSOR-BY-CONVERSION TO CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; GEN-PROBE INCORPORATED, ON ITS OWN BEHALF AND AS SUCCESSOR-BY-MERGER TO THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE PRODESSE, INC.; SUROS SURGICAL SYSTEMS, INC.
Reel/Frame 075566/0039 →
SECURITY INTEREST Recorded Apr 8, 2026
From: BIOTHERANOSTICS, INC.; GEN-PROBE INCORPORATED; GEN-PROBE PRODESSE, INC.; CYTYC CORPORATION; SUROS SURGICAL SYSTEMS, INC.; GYNESONICS, INC.; BOLDER SURGICAL, LLC; FAXITRON BIOPTICS, LLC; HEALTH BEACONS, INC.; HOLOGIC, INC.
To: ROYAL BANK OF CANADA, AS COLLATERAL AGENT
Reel/Frame 075462/0440 →
CORRECTIVE ASSIGNMENT TO CORRECT THE INCORRECT PATENT NO. 8081301 PREVIOUSLY RECORDED AT REEL: 035820 FRAME: 0239. ASSIGNOR(S) HEREBY CONFIRMS THE SECURITY INTEREST RELEASE. Recorded Nov 9, 2017
From: GOLDMAN SACHS BANK USA, AS COLLATERAL AGENT
To: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE INCORPORATED
Reel/Frame 044727/0529 →
CORRECTIVE ASSIGNMENT TO CORRECT THE INCORRECT PATENT NO. 8081301 PREVIOUSLY RECORDED AT REEL: 028810 FRAME: 0745. ASSIGNOR(S) HEREBY CONFIRMS THE SECURITY AGREEMENT. Recorded Nov 9, 2017
From: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE INCORPORATED
To: GOLDMAN SACHS BANK USA
Reel/Frame 044432/0565 →
SECURITY AGREEMENT Recorded Aug 7, 2015
From: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; DIRECT RADIOGRAPHY CORP.; GEN-PROBE INCORPORATED; GEN-PROBE PRODESSE, INC.; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.
To: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
Reel/Frame 036307/0199 →
SECURITY INTEREST RELEASE REEL/FRAME 028810/0745 Recorded Jun 4, 2015
From: GOLDMAN SACHS BANK USA, AS COLLATERAL AGENT
To: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE INCORPORATED
Reel/Frame 035820/0239 →
SECURITY AGREEMENT Recorded Aug 1, 2012
From: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE INCORPORATED
To: GOLDMAN SACHS BANK USA
Reel/Frame 028810/0745 →
TERMINATION OF PATENT SECURITY AGREEMENTS AND RELEASE OF SECURITY INTERESTS Recorded Aug 26, 2010
From: GOLDMAN SACHS CREDIT PARTNERS, L.P., AS COLLATERAL AGENT
To: HOLOGIC, INC.; R2 TECHNOLOGY, INC.; SUROS SURGICAL SYSTEMS, INC.; BIOLUCENT, LLC; DIRECT RADIOGRAPHY CORP.; CYTYC SURGICAL PRODUCTS II LIMITED PARTNERSHIP; CYTYC SURGICAL PRODUCTS LIMITED PARTNERSHIP; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS III, INC.; CYTYC PRENATAL PRODUCTS CORP.; THIRD WAVE TECHNOLOGIES, INC.
Reel/Frame 024892/0001 →
THIRD SUPPLEMENT TO PATENT SECURITY AGREEMENT Recorded Nov 10, 2008
From: SUROS SURGICAL SYSTEMS, INC.
To: GOLDMAN SACHS CREDIT PARTNERS L.P., AS COLLATERAL AGENT
Reel/Frame 021812/0424 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 30, 2008
From: MARK, JOSEPH L.; MILLER, MICHAEL E.
To: SUROS SURGICAL SYSTEMS, INC.
Reel/Frame 021608/0529 →