IP Library › Patent Application 12242264
Patent Application
App. No. 12/242,264

BIOMARKERS OVEREXPRESSED IN PROSTATE CANCER

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Patent No.
US None
App. No.
12/242,264
Abstract

Biomarkers are identified by analyzing gene expression data using support vector machines (SVM) to rank genes according to their ability to separate prostate cancer from normal tissue. Proteins expressed by identified genes are detected in patient samples to screen, predict and monitor prostate cancer.

Claims (9)

1 - 4 . (canceled)

5 . A biomarker comprising a small set of genes for screening, predicting and/or monitoring prostate cancer comprising any combination of from three to ten genes selected from the group consisting of Unigene ID numbers Hs.7780 (SEQ ID NO. 1), Hs.21293 (SEQ ID NO. 2), Hs. 79037 (SEQ ID NO. 3), Hs.30054 (SEQ ID NO. 4), Hs.75432 (SEQ ID NO. 5), Hs.699 (SEQ ID NO. 6), Hs.1708 (SEQ ID NO. 7), Hs.69469 (SEQ ID NO. 8), Hs.82280 (SEQ ID NO. 9) and Hs.79217 (SEQ ID NO. 10).

6 . The biomarker of claim 5 , wherein the genes comprise Unigene ID numbers Hs.7780 (SEQ ID NO. 1), Hs.21293 (SEQ ID NO. 2) and Hs.75432 (SEQ ID NO. 5).

7 . The biomarker of claim 5 , wherein the genes comprise Unigene ID numbers Hs.7780 (SEQ ID NO. 1), Hs.21293 (SEQ ID NO. 2) and Hs.79037 (SEQ ID NO. 3).

8 . The biomarker of claim 5 , wherein the genes comprise Unigene ID numbers Hs.7780 (SEQ ID NO. 1), Hs.21293 (SEQ ID NO. 2) and Hs.79037 (SEQ ID NO. 3) and Hs.75432 (SEQ ID NO. 5).

9 . A biomarker combination for screening, predicting and/or monitoring prostate cancer comprising any combination of from three to ten genes or their respective protein products, wherein the three to ten genes are selected from the group consisting of Unigene ID numbers Hs.7780 (SEQ ID NO. 1), Hs.21293 (SEQ ID NO. 2), Hs. 79037 (SEQ ID NO. 3), Hs.30054 (SEQ ID NO. 4), Hs.75432 (SEQ ID NO. 5), Hs.699 (SEQ ID NO. 6), Hs.1708 (SEQ ID NO. 7), Hs.69469 (SEQ ID NO. 8), Hs.82280 (SEQ ID NO. 9) and Hs.79217 (SEQ ID NO. 10).

10 . The biomarker combination of claim 9 , wherein the genes comprise Unigene ID numbers Hs.7780 (SEQ ID NO.1), Hs.21293 (SEQ ID NO.2) and Hs.75432 (SEQ ID NO. 5).

11 . The biomarker combination of claim 9 , wherein the genes comprise Unigene ID numbers Hs.7780 (SEQ ID NO. 1), Hs.21293 (SEQ ID NO. 2) and Hs.79037 (SEQ ID NO. 3).

12 . The biomarker combination of claim 9 , wherein the genes comprise Unigene ID numbers Hs.7780 (SEQ ID NO. 1), Hs.21293 (SEQ ID NO. 2) and Hs.79037 (SEQ ID NO. 3) and Hs.75432 (SEQ ID NO. 5).

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 3, 2008
From: GUYON, ISABELLE
To: HEALTH DISCOVERY CORPORATION
Reel/Frame 021632/0271 →