2-{(R)-2-methylpyrrolidin-2-yl)-1H-benzimidazole-4-carboxamide crystalline form 2

1. 2-((R)-2-Methylpyrrolidin-2-yl)-1H-benzimidazole-4-carboxamide Crystalline Form 2 which, when measured at about −100° C. in the trigonal crystal system and P3 2 space group with radiation at 0.7107 Å, is characterized by respective lattice parameter values a, b and c of 8.599 ű0.002 Å, 8.599 ű0.002 Å and 14.526 ű0.006 Å and respective α, β and γ values of 90°, 90° and 120°.

2. 2-((R)-2-Methylpyrrolidin-2-yl)-1H-benzimidazole-4-carboxamide Crystalline Form 2 which, when measured at about 25° C. with radiation at 1.54178 Å, is characterized by a powder diffraction pattern having at least three respective 2θ values of about 13.4°, 17.1°, 21.6°, 21.9°, 24.1°, 24.7°, 26.9°, 27.3°, 27.8°, 30.3°, 32.4° and 34.2° and essentially without peaks below about 11.5°.

3. A composition comprising an excipient and 2-((R)-2-Methylpyrrolidin-2-yl)-1H-benzimidazole-4-carboxamide Crystalline Form 2 which, when measured at about 25° C. with radiation at 1.54178 Å, is characterized by a powder diffraction pattern having respective 2θ values of about 9.9°, 11.0° and 11.8° and one or more than one additional peaks having respective 2θ values of about 13.4°, 17.1°, 21.6°, 21.9°, 24.1°, 24.7°, 26.9°, 27.3°, 27.8°, 30.3°, 32.4° and 34.2° and essentially without peaks below about 11.5°.

4. A method of treating cancer in a mammal comprising administering thereto, with or without one or more than one additional anticancer drugs, a therapeutically effective amount of 2-((R)-2-Methylpyrrolidin-2-yl)-1H-benzimidazole-4-carboxamide Crystalline Form 2 which, when measured at about −100° C. in the trigonal crystal system and P3 2 space group with radiation at 0.7107 Å, is characterized by respective lattice parameter values a, b and c of 8.599 ű0.002 Å, 8.599 ű0.002 Å and 14.526 ű0.006 Å and respective α, β and γ values of 90°, 90° and 120°.

5. A process for making 2-((R)-2-Methylpyrrolidin-2-yl)-1H-benzimidazole-4-carboxamide Crystalline Form 2, comprising:

providing a mixture comprising 2-((R)-2-methylpyrrolidin-2-yl)-1H-benzimidazole-4-carboxamide and solvent, wherein the 2-((R)-2-methylpyrrolidin-2-yl)-1H-benzimidazole-4-carboxamide is completely dissolved in the solvent;

causing 2-((R)-2-Methylpyrrolidin-2-yl)-1H-benzimidazole-4-carboxamide Crystalline Form 2 to exist in the mixture, which 2-((R)-2-Methylpyrrolidin-2-yl)-1H-benzimidazole-4-carboxamide Crystalline Form 2, which, when isolated and measured at about −100° C. in the trigonal crystal system and P3 2 space group with radiation at 0.7107 Å, is characterized by respective lattice parameter values a, b and c of 8.599 ű0.002 Å, 8.599 ű0.002 Å and 14.526 ű0.006 Å and respective α, β and γ values of 90°, 90° and 120°.

6. The process of claim 5 further comprising isolating the 2-((R)-2-Methylpyrrolidin-2-yl)-1H-benzimidazole-4-carboxamide Crystalline Form 2.