Compositions comprising at least one aqueous phase and at least one fatty phase which comprises avermectin compounds

1. A pharmaceutical/dermatological emulsion which comprises at least one fatty phase, at least one aqueous phase and at least one avermectin compound, said at least one fatty phase comprising at least one oily solvent other than a mineral or plant oil, said avermectin compound being solubilized in said at least one oily solvent to form an active phase, said active phase being devoid of any solvent for said avermectin compound distinct from said at least one oily solvent; said emulsion consisting essentially of:

a first fatty phase which is a solvent for the at least one avermectin compound, in an amount of from 0.01% to 25% by weight, said first fatty phase consisting essentially of at least one oily solvent selected from the group consisting of diisopropyl adipate, PPG 15 stearyl ether, octyl dodecanol, C 12 -C 15 alkyl benzoate and mixtures thereof;

a second fatty phase which is not a solvent for the at least one avermectin compound, in an amount of up to 20% by weight, said second fatty phase consisting essentially of at least one member selected from the group consisting of silicone oils, mineral oils, stearyl alcohol, cetyl alcohol, waxes, butters and mixtures thereof;

at least one avermectin compound;

at least one emulsifier, in an amount of 1% to 8% by weight;

a gelling agent, in an amount of up to 5% by weight;

an aqueous phase, in an amount of from 50% to 75% by weight;

and one or more additives selected from the group consisting of humectants, preservatives, anti-irritants, moisture regulators, pH regulators, osmotic pressure modifiers, UV-A and UV-B screens and antioxidants.

2. A pharmaceutical/dematological emulsion which comprises at least one fatty phase, at least one aqueous phase and at least one avermectin compound, said at least one fatty phase comprising at least one oily solvent other than a mineral or plant oil, said avermectin compound being solubilized in said at least one oily solvent to form an active phase, said active phase being devoid of any solvent for said avermectin compound distinct from said at least one oily solvent, said active phase also being devoid of emulsifier; said emulsion consisting essentially of:

a first fatty phase which is a solvent for the at least one avermectin compound, in an amount of from 0.01% to 25% by weight, said first fatty phase consisting essentially of at least one oily solvent selected from the group consisting of diisopropyl adipate, PPG 15 stearyl ether, octyl dodecanol, C 12 -C 15 alkyl benzoate and mixtures thereof;

a second fatty phase which is not a solvent for the at least one avermectin compound, in an amount of up to 20% by weight, said second fatty phase consisting essentially of at least one member selected from the group consisting of silicone oils, mineral oils, stearyl alcohol, cetyl alcohol, waxes, butters and mixtures thereof;

at least one avermectin compound;

a gelling agent, in an amount of up to 5% by weight;

an aqueous phase, in an amount of from 50% to 75% by weight;

and one or more additives selected from the group consisting of humectants, preservatives, anti-irritants, moisture regulators, pH regulators, osmotic pressure modifiers, UV-A and UV-B screens and antioxidants.

3. The pharmaceutical/dermatological emulsion as defined by claim 1 , said avermectin compound being selected from the group consisting of ivermectin, invermectin, avermectin, abamectin, doramectin, eprinomectin and selamectin.

4. The pharmaceutical/dermatological emulsion as defined by claim 3 , said avermectin compound being ivermectin.

5. The pharmaceutical/dermatological emulsion as defined by claim 1 , which is an oil-in-water emulsion.

6. The pharmaceutical/dermatological emulsion as defined by claim 3 , wherein the amount of ivermectin is from 0.001% to 10% by weight, relative to the total weight thereof.

7. The pharmaceutical/dermatological emulsion as defined by claim 1 , wherein said avermectin compound is ivermectin and wherein at least the oily solvent diisopropyl adipate is present in said first fatty phase.

8. The pharmaceutical/dermatological emulsion as defined by claim 1 , wherein said avermectin compound is ivermectin and wherein a silicone oil is present in said second fatty phase.

9. The pharmaceutical/dermatological emulsion as defined by claim 8 , wherein said silicone oil comprises dimethicone.

10. The pharmaceutical/dermatological emulsion as defined by claim 8 , wherein at least the oily solvent diisopropyl adipate is present in said first fatty phase.

11. The pharmaceutical/dermatological emulsion as defined by claim 9 , wherein at least the oily solvent diisopropyl adipate is present in said first fatty phase.

12. The pharmaceutical/dermatological emulsion as defined by claim 4 , comprising from 0.001% to 5% by weight of ivermectin.

13. The pharmaceutical/dermatological emulsion as defined by claim 4 , comprising from 0.003% to 2% by weight of ivermectin.

14. The pharmaceutical/dermatological emulsion as defined by claim 1 , wherein said first fatty phase is present in an amount of from 5% to 20% by weight, said second fatty phase is present in an amount of up to 10% by weight, said at least one emulsifier is present in an amount of 2% to 5% by weight, said gelling agent is present in an amount of up to 3% by weight and said aqueous phase is present in an amount of from 55% to 70% by weight.

15. The pharmaceutical/dermatological emulsion as defined by claim 14 , comprising from 0.001% to 2% of ivermectin.

16. The pharmaceutical/dermatological emulsion as defined by claim 2 , said avermectin compound being selected from the group consisting of ivermectin, invermectin, avermectin, abamectin, doramectin, eprinomectin and selamectin.

17. The pharmaceutical/dermatological emulsion as defined by claim 16 , said avermectin compound being ivermectin.

18. The pharmaceutical/dermatological emulsion as defined by claim 17 , wherein the amount of ivermectin is from 0.001% to 10% by weight.

19. The pharmaceutical/dermatological emulsion as defined by claim 17 , comprising from 0.001% to 5% by weight of ivermectin.

20. The pharmaceutical/dermatological emulsion as defined by claim 17 , comprising from 0.003% to 2% by weight of ivermectin.

21. The pharmaceutical/dermatological emulsion as defined by claim 14 , wherein said first fatty phase is present in an amount of from 5% to 20% by weight, said second fatty phase is present in an amount of up to 10% by weight, said gelling agent is present in an amount of up to 3% by weight and said aqueous phase is present in an amount of from 55% to 70% by weight.

22. The pharmaceutical/dermatological emulsion as defined by claim 21 , comprising from 0.001% to 2% of ivermectin.