IP Library Granted Patent US 8,412,332
Granted Patent B2
US 8,412,332 · App. 12/254,383 · Granted Apr 2, 2013

Miniature wireless system for deep brain stimulation

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Quick Facts
Patent No.
US 8,412,332
App. No.
12/254,383
Granted
Apr 2, 2013
Kind
B2
Abstract

An implantable system and method for deep brain stimulation (DBS) treatments. The implantable system is sufficiently small and self-contained to enable implantation of the entire system within the brain, or optionally within the brain and the surrounding tissue. The system comprises an implantable inductor on which a voltage is induced when subjected to an electromagnetic field, and an implantable device comprising a housing, stimulating elements at an exterior surface of the housing, and electronics within the housing and electrically connected to the implantable inductor. The electronics produces a brain-stimulating current from the voltage induced on the implantable inductor and then delivers the brain-stimulating current to the stimulating elements. Deep brain stimulation is performed by subjecting the inductor to an electromagnetic field to induce a voltage on the inductor that powers the electronics to produce and deliver the brain-stimulating current to the stimulating elements.

Claims (27)

1. An implantable system for performing deep brain stimulation, the system comprising:

an implantable inductor on which a voltage is induced when subjected to an electromagnetic field; and

an implantable device comprising a housing, conductive stimulating elements located and formed on an exterior surface of the housing, and electronics within the housing and electrically connected to the implantable inductor, the electronics producing a brain-stimulating current from the voltage induced on the implantable inductor and then delivering the brain-stimulating current to the stimulating elements;

wherein the housing and the stimulating elements are configured for deep brain implantation together;

wherein the stimulating elements are spaced apart at the exterior surface of the housing and comprise at least two two-dimensional structures located and formed on the exterior surface of the housing or at least two three-dimensional structures that protrude through the exterior surface of the housing; and

wherein the implantable inductor is entirely outside the housing of the device and has a flat coil configuration that enables the implantable inductor to be implanted separate from the housing and the stimulating elements, between the skull and the scalp and lie flat against the skull.

2. The system according to claim 1 , wherein the implantable inductor is adapted for receiving the electromagnetic field from a non-implantable powering source.

3. The system according to claim 1 , wherein the stimulating elements comprise the at least two two-dimensional structures located and formed on the exterior surface of the housing and do not protrude from the exterior surface of the housing.

4. The system according to claim 1 , wherein the stimulating elements comprise the at least two three-dimensional structures that protrude through the exterior surface of the housing.

5. The system according to claim 1 , wherein the housing has a hollow interior that contains the electronics of the implantable device.

6. The system according to claim 1 , wherein the housing is a potted structure in which the electronics of the implantable device are potted.

7. The system according to claim 1 , wherein the implantable inductor is connected to the housing by a cable.

8. The system according to claim 7 , wherein the inductive coil is defined on a planar film.

9. The system according to claim 1 , wherein the device further comprises an additional element adapted to sense a physiological parameter chosen from the group consisting of pressure, temperature, flow, velocity, vibration, acceleration, and chemistry, and the system uses the sensed physiologic parameter to control, adjust or manipulate the brain-stimulating current.

10. The system according to claim 1 , wherein the device further comprises an actuator chosen from the group consisting of thermal generators, voltage sources, current sources, probes, electrodes, drug delivery pumps, valves, meters, microtools for localized surgical procedures, and radiation emitting sources.

11. A method of performing deep brain stimulation, the method comprising:

providing a device comprising a housing, electronics within the housing, conductive stimulating elements located and formed on an exterior surface of the housing, and an inductor entirely outside the housing and having a flat coil configuration, the stimulating elements being spaced apart at the exterior surface of the housing and comprising at least two two-dimensional structures located and formed on the exterior surface of the housing or at least two three-dimensional structures that protrude through the exterior surface of the housing, the electronics being electrically connected to the inductor and adapted to produce and deliver a brain-stimulating current to the stimulating elements;

implanting together the housing and the stimulating elements attached thereto deep within the brain;

implanting the inductor separately from the housing and the stimulating elements and between the skull and the scalp such that the inductor lies flat against the skull; and

subjecting the inductor to an electromagnetic field to induce a voltage on the inductor that powers the electronics to produce and deliver the brain-stimulating current to the stimulating elements.

12. The method according to claim 11 , wherein the inductor receives the electromagnetic field from a non-implanted powering source.

13. The method according to claim 11 , wherein the stimulating elements comprise the at least two two-dimensional structures located and formed on the exterior surface of the housing and do not protrude from the exterior surface of the housing.

14. The method according to claim 11 , wherein the stimulating elements comprise the at least two three-dimensional structures that protrude through the exterior surface of the housing.

15. The method according to claim 11 , wherein the inductor is connected to the housing by a cable.

16. The method according to claim 15 , wherein the inductive coil is defined on a planar film.

17. The method according to claim 11 , wherein the device further comprises an additional element that senses a physiological parameter chosen from the group consisting of pressure, temperature, flow, velocity, vibration, acceleration, and chemistry, and the method further comprises using the sensed physiologic parameter to control, adjust or manipulate the brain-stimulating current.

18. The method according to claim 11 , wherein the device further comprises an actuator chosen from the group consisting of thermal generators, voltage sources, current sources, probes, electrodes, drug delivery pumps, valves, meters, microtools for localized surgical procedures, and radiation emitting sources.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 27, 2022
From: INTEGRATED SENSING SYSTEMS INCORPORATED
To: UIM PRESSURE IMPLANT INC.
Reel/Frame 061220/0908 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 17, 2008
From: MASSOUD-ANSARI, SONBOL; NAJAFI, NADER (NMN)
To: INTEGRATED SENSING SYSTEMS, INC.
Reel/Frame 021844/0614 →