PLATELET GLYCOPROTEIN IB ALPHA FUSION POLYPEPTIDES AND METHODS OF USE THEREOF
The present invention provides compositions and methods for treating or preventing vascular-associated disorders.
1 - 53 . (canceled)
54 . A method for treating a disorder associated with platelet activation in a subject, the method comprising administering to a subject in need thereof a polypeptide comprising the amino acid sequence of SEQ ID NO:5.
55 . A method for treating venous or coronary artery thrombosis in a subject in need thereof comprising administering to the subject a polypeptide comprising the amino acid sequence of SEQ ID NO:5.
56 . The method of claim 54 , wherein the disorder is selected from the group consisting of restenosis, ischemic heart disease, angina, unstable angina, atherosclerosis, acute myocardial infarction, or vascular inflammation.
57 . The method of claim 56 , wherein the disorder is restenosis.
58 . The method of claim 56 , wherein the disorder is angina.
59 . The method of claim 58 , wherein the disorder is unstable angina.
60 . The method of claim 56 , wherein the disorder is ischemic heart disease.
61 . The method of claim 56 , wherein the disorder is atherosclerosis.
62 . The method of claim 56 , wherein the disorder is acute myocardial infarction.
63 . The method of claim 56 , wherein the disorder is vascular inflammation.
64 . The method of claim 54 , wherein the method further comprises administering a compound selected from the group consisting of acetylsalicylic acid, heparin, and clopidogrel.
65 . The method of claim 55 , wherein the method further comprises administering a compound selected from the group consisting of acetylsalicylic acid, heparin, and clopidogrel.
66 . The method of claim 54 , wherein the method further comprises administering a glycoprotein IIb/IIIa antagonist, a P-selectin antagonist, a thrombin inhibitor, or a thrombolytic enzyme.
67 . The method of claim 55 , wherein the method further comprises administering a glycoprotein IIb/IIIa antagonist, a P-selectin antagonist, a thrombin inhibitor, or a thrombolytic enzyme.
68 . The method of claim 54 , wherein the subject is a mammal.
69 . The method of claim 55 , wherein the subject is a mammal.
70 . The method of claim 54 , wherein the subject is human.
71 . The method of claim 55 , wherein the subject is human.
72 . The method of claim 54 , wherein the polypeptide is a dimer.
73 . The method of claim 55 , wherein the polypeptide is a dimer.