IP Library › Granted Patent US 8,722,739
Granted Patent B2
US 8,722,739 · App. 12/260,522 · Granted May 13, 2014

Amino acid salts of prostaglandins

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Quick Facts
Patent No.
US 8,722,739
App. No.
12/260,522
Granted
May 13, 2014
Kind
B2
Abstract

The present invention is directed to novel amino acid prostaglandin salts and methods of making and using them.

Claims (8)

1. Latanoprost free acid arginine salt, wherein the free acid salt is crystalline.

2. The salt according to claim 1 , wherein the salt is a product of a reaction between latanoprost free acid and arginine.

3. A pharmaceutical composition comprising a salt according to claim 1 and a pharmaceutically acceptable carrier.

4. A method of treating glaucoma disease comprising administering to a subject in need thereof an effective amount of a salt according to claim 1 .

5. A method of improving nasal patency or treating neurogenic bladder comprising administering to a subject in need thereof an effective amount of a salt according to claim 1 .

6. A method of treating osteoporosis comprising administering to a subject in need thereof an effective amount of a salt according to claim 1 .

7. A method of reducing ocular pressure comprising contacting a cell with an amount of a salt according to claim 1 effective to reduce ocular pressure.

8. The method of claim 7 , wherein the cell is in a subject.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 19, 2014
From: AERIE PHARMACEUTICALS, INC.
To: NOVAER HOLDINGS, INC.
Reel/Frame 032477/0610 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 29, 2008
From: DELONG, MITCHELL A.; STURDIVANT, JILL MARIE
To: AERIE PHARMACEUTICALS, INC.
Reel/Frame 022033/0251 →