Controlled drug delivery using a zein layer modified with levulinic acid
View Patent ↗The disclosure relates to medical devices coated with zein admixed with levulinic acid. The medical device may further include a therapeutic agent in contact with zein admixed with levulinic acid. Zein admixed with levulinic acid allows the therapeutic agent to be retained on the device during delivery and also controls the elution rate of the therapeutic agent following implantation. The disclosure further relates to methods of delivering a therapeutic agent on said medical devices as well as their use especially in the form of stents for prevention of restenosis.
1. An expandable medical device comprising a frame and a coating, wherein the coating comprises from about 0.05 to about 40 μg of zein or modified zein admixed with levulinic acid per mm 2 of the coated surface of the medical device, wherein levulinic acid increases flexibility of the coating to accommodate deformations of the expandable medical device.
2. The device of claim 1 , wherein the coating further comprises therapeutic agent.
3. The device of claim 2 , wherein the therapeutic agent is hydrophobic.
4. The device of claim 2 , wherein the coating further comprises about 1:1 to about 1:20 weight ratio of therapeutic agent to zein or modified zein admixed with levulinic acid.
5. The device of claim 2 , wherein the coating further comprises about 1:1 to about 1:5 weight ratio of therapeutic agent to zein or modified zein admixed with levulinic acid.
6. The medical device of claim 1 , wherein the coating further comprises at least two layers, a first layer comprising a therapeutic agent and a second layer comprising zein or modified zein admixed with levulinic acid.
7. The medical device of claim 6 , wherein the second layer at least partially covers the first layer.
8. The device of claim 6 , wherein the first layer is substantially covered by the second layer.
9. The device of claim 2 , wherein the therapeutic agent is selected from the group consisting of anti-inflammatory/immunomodulators, antiproliferatives, migration inhibitors/ECM-modulators, and agents that promote healing.
10. The device of claim 9 , wherein the therapeutic agent is paclitaxel or a paclitaxel derivative.
11. The device of claim 1 , wherein the thickness of the coating on at least one point on the surface of the device is between about 0.2-10 microns.
12. The device of claim 1 , wherein the medical device is selected from the group consisting of stents, stent grafts, vascular grafts, catheters, guide wires, balloons, filters, cerebral aneurysm filler coils, intraluminal paving systems, sutures, staples, anastomosis devices, vertebral disks, bone pins, suture anchors, hemostatic barriers, clamps, screws, plates, clips, slings, vascular implants, tissue adhesives and sealants, tissue scaffolds, myocardial plugs, pacemaker leads, valves, abdominal aortic aneurysm (AAA) grafts, embolic coils, various types of dressings, bone substitutes, intraluminal devices, and vascular supports.
13. The device of claim 1 , wherein the frame is selected from the group consisting of stainless steel, nitinol, tantalum, a nonmagnetic nickel-cobalt-chromium-molybdenum [MP35N] alloy, platinum, titanium, a suitable biocompatible alloy, a suitable biocompatible material, and a combination thereof.
14. A medical device comprising a frame and a coating, the coating being the product of deposition of zein or modified zein solution comprising 1 to 3 drops of levulinic acid per 10 mL of the solution, and wherein from about 0.05 to about 40 μg of zein is present per mm 2 of the coated surface of the medical device, the coating comprising about 1:1 to about 1:20 weight ratio taxane therapeutic agent to zein or modified zein admixed with levulinic acid.
15. The device of claim 14 , wherein the coating comprises about 0.01 to about 1.5 μg of taxane therapeutic agent per mm 2 of the frame.
16. The device of claim 14 , wherein the coating comprises about 0.3 to about 1.0 μg of therapeutic agent per mm 2 of the frame.
17. The device of claim 14 , wherein the medical device is selected from the group consisting of stents, stent grafts, vascular grafts, catheters, guide wires, balloons, filters, cerebral aneurysm filler coils, intraluminal paving systems, sutures, staples, anastomosis devices, vertebral disks, bone pins, suture anchors, hemostatic barriers, clamps, screws, plates, clips, slings, vascular implants, tissue adhesives and sealants, tissue scaffolds, myocardial plugs, pacemaker leads, valves, abdominal aortic aneurysm (AAA) grafts, embolic coils, various types of dressings, bone substitutes, intraluminal devices, and vascular supports.
18. The device of claim 14 , wherein the medical device is a vascular stent.
19. The device of claim 14 , wherein the therapeutic agent is paclitaxel or a paclitaxel derivative.
20. A method of delivering a therapeutic agent to a patient in need thereof comprising the steps of
providing an expandable medical device and
implanting the medical device in a patient wherein the medical device comprises
at least one therapeutic agent and
a coating comprising from about 0.05 to about 40 μg of zein admixed with levulinic acid per mm 2 of the coated surface of the medical device with a ratio of about 1:1 to about 1:20 by weight of the at least one therapeutic agent to zein admixed with levulinic acid, and wherein levulinic acid increases flexibility of the coating to accommodate deformations of the expandable medical device during the implanting step.