Protein kinase inhibitors
View Patent ↗Compounds that inhibit protein kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.
1. A compound having Formula I
or a therapeutically acceptable salt thereof, wherein
X is N;
A 1 is NHR 1 , NHC(O)R 1 , NHC(O)NHR 1 , NHC(O)OR 1 , C═NOR 1 , or C(NH 2 )NOC(O)R 1 ;
B 1 , C 1 , D 1 , and E 1 , are each independently H, OR 1 , NHR 1 , N(R 1 ) 2 , OH, CN, N 3 , NO 2 , CF 3 , CF 2 CF 3 , OCF 3 , OCF 2 CF 3 , F, Cl, Br, or I;
G 1 and H 1 are H;
R 1 is R 2 , R 3 , R 4 or R 5 ;
R 2 is phenyl which is unfused or fused with benzene, heteroarene or R 2A ; R 2A is cycloalkane, cycloalkene, heterocycloalkane or heterocycloalkene;
R 3 is heteroaryl which is unfused or fused with benzene, heteroarene or R 3A ; R 3A is cycloalkane, cycloalkene, heterocycloalkane or heterocycloalkene;
R 4 is cycloalkyl, cycloalkenyl, heterocycloalkyl or heterocycloalkenyl, each of which is unfused or fused with benzene, heteroarene or R 4A ; R 4A is cycloalkane, cycloalkene, heterocycloalkane or heterocycloalkene;
R 5 is alkyl, alkenyl, or alkynyl, each of which is unsubstituted or substituted with one, two, three, four or five of independently selected spiroalkyl, R 6 ,
R 6 is R 7 , R 8 , or R 9 ;
R 7 is phenyl which is unfused or fused with benzene, heteroarene or R 7A ; R 7A is cycloalkane, cycloalkene, heterocycloalkane or heterocycloalkene;
R 8 is heteroaryl which is unfused or fused with benzene, heteroarene or R 8A ; R 8A is cycloalkane, cycloalkene, heterocycloalkane or heterocycloalkene;
R 9 is cycloalkyl, cycloalkenyl, heterocycloalkyl or heterocycloalkenyl, each of which is unfused or fused with benzene, heteroarene or R 9A ; R 9A is cycloalkane, cycloalkene, heterocycloalkane or heterocycloalkene;
F 1 is H, R 10 , C(O)R 10 , R 11 or R 110 ;
R 10 is phenyl which is unfused or fused with R 10A ; R 10A is benzene, heteroarene, cycloalkane, cycloalkene, heterocycloalkane, or heterocycloalkene;
R 11 is heteroaryl which is unfused or fused with R 11A ; R 11A is benzene, heteroarene, cycloalkane, cycloalkene, heterocycloalkane, or heterocycloalkene;
R 110 is alkyl which is unsubstituted or substituted with R 111 ;
R 111 is R 112 ;
R 112 is phenyl which is unfused or fused with benzene or heteroarene;
wherein each foregoing variable cyclic moiety is independently unsubstituted or substituted with one or two or three or four or five of independently selected R 12 , OR 12 , SR 12 , S(O)R 12 , SO 2 R 12 , C(O)R 12 , CO(O)R 12 , OC(O)R 12 , OC(O)OR 12 , NH 2 , NHR 12 , N(R 12 ) 2 , NHC(O)R 12 , NR 12 C(O)R 12 , NHS(O) 2 R 12 , NR 12 S(O) 2 R 12 , NHC(O)OR 12 , NR 12 C(O)OR 12 , NHC(O)NH 2 , NHC(O)NHR 12 , NHC(O)N(R 12 ) 2 , NR 12 C(O)NHR 12 , NR 12 C(O)N(R 12 ) 2 , NHSO 2 R 12 , C(O)NH 2 , C(O)NHR 12 , C(O)N(R 12 ) 2 , C(O)NHOH, C(O)NHOR 12 , C(O)NHSO 2 R 12 , C(O)NR 12 SO 2 R 12 , SO 2 NH 2 , SO 2 NHR 12 , SO 2 N(R 12 ) 2 , C(O)H, C(O)OH, C(N)NH 2 , C(N)NHR 12 , C(N)N(R 12 ) 2 , CNOH, CNOCH 3 , OH, (O), CN, N 3 , NO 2 , CF 3 , CF 2 CF 3 , OCF 3 , OCF 2 CF 3 , F, Cl, Br or I;
R 12 is R 13 , R 14 , R 15 , or R 16 ;
R 13 is phenyl which is unfused or fused with benzene, heteroarene or R 13A ; R 13A is cycloalkane, cycloalkene, heterocycloalkane or heterocycloalkene;
R 14 is heteroaryl which is unfused or fused with benzene, heteroarene or R 14A ; R 14A is cycloalkane, cycloalkene, heterocycloalkane or heterocycloalkene;
R 15 is cycloalkyl, cycloalkenyl, heterocycloalkyl or heterocycloalkenyl, each of which is unfused or fused with benzene, heteroarene or R 15A ; R 15A is cycloalkane, cycloalkene, heterocycloalkane or heterocycloalkene;
R 16 is alkyl, alkenyl, or alkenyl, each of which is unsubstituted or substituted with one, two, three, four or five of independently selected R 17 , OR 17 , SR 17 , S(O)R 17 , SO 2 R 17 , C(O)R 17 , CO(O)R 17 , OC(O)R 17 , OC(O)OR 17 , NH 2 , NHR 17 , N(R 17 ) 2 , NHC(O)R 17 , NR 17 C(O)R 17 , NHS(O) 2 R 17 , NR 17 S(O) 2 R 17 , NHC(O)OR 17 , NR 17 C(O)OR 17 , NHC(O)NH 2 , NHC(O)NHR 17 , NHC(O)N(R 17 ) 2 , NR 17 C(O)NHR 17 , NR 17 C(O)N(R 17 ) 2 , C(O)NH 2 , C(O)NHR 17 , C(O)N(R 17 ) 2 , C(O)NHOH, C(O)NHOR 17 , C(O)NHSO 2 R 17 , C(O)NR 17 SO 2 R 17 , SO 2 NH 2 , SO 2 NHR 17 , SO 2 N(R 7 ) 2 , C(O)H, C(O)OH, C(N)NH 2 , C(N)NHR 17 , C(N)N(R 17 ) 2 , CNOH, CNOCH 3 , OH, (O), CN, N 3 , NO 2 , CF 3 , CF 2 CF 3 , OCF 3 , OCF 2 CF 3 , F, Cl, Br or I;
R 17 is R 18 , R 19 , R 20 or R 21 ;
R 18 is phenyl which is unfused or fused with benzene, heteroarene or R 18A ; R 18A is cycloalkane, cycloalkene, heterocycloalkane or heterocycloalkene;
R 19 is heteroaryl which is unfused or fused with benzene, heteroarene or R 19A ; R 19A is cycloalkane, cycloalkene, heterocycloalkane or heterocycloalkene;
R 20 is cycloalkyl, cycloalkenyl, heterocycloalkyl or heterocycloalkenyl, each of which is unfused or fused with benzene, heteroarene or R 20A ; R 20A is cycloalkane, cycloalkene, heterocycloalkane or heterocycloalkene;
R 21 is alkyl, alkenyl, or alkenyl, each of which is unsubstituted or substituted with one, two, three, four or five of independently selected R 22 , OR 22 , SR 22 , S(O)R 22 , SO 2 R 22 , C(O)R 22 , CO(O)R 22 , OC(O)R 22 , OC(O)OR 22 , NH 2 , NHR 22 , N(R 22 ) 2 , NHC(O)R 22 , NR 22 C(O)R 22 , NHS(O) 2 R 22 , NR 22 S(O) 2 R 22 , NHC(O)OR 22 , NR 22 C(O)OR 22 , NHC(O)NH 2 , NHC(O)NHR 22 , NHC(O)N(R 22 ) 2 , NR 22 C(O)NHR 22 , NR 22 C(O)N(R 22 ) 2 , C(O)NH 2 , C(O)NHR 22 , C(O)N(R 22 ) 2 , C(O)NHOH, C(O)NHOR 22 , C(O)NHSO 2 R 22 , C(O)NR 22 SO 2 R 22 , SO 2 NH 2 , SO 2 NHR 22 , SO 2 N(R 22 ) 2 , C(O)H, C(O)OH, C(N)NH 2 , C(N)NHR 22 , C(N)N(R 22 ) 2 , CNOH, CNOCH 3 , OH, (O), CN, N 3 , NO 2 , CF 3 , CF 2 CF 3 , OCF 3 , OCF 2 CF 3 , F, Cl, Br or I;
R 22 is alkyl, alkenylalkenyl, heteroaryl, cycloalkenyl or heterocycloalkyl;
wherein the moieties represented by R 13 , R 14 , R 15 , R 18 , R 19 , R 20 , and R 22 are independently unsubstituted or substituted with one or two or three or four or five of independently selected R 23 , OR 23 , SR 23 , S(O)R 23 , SO 2 R 23 , C(O)R 23 , CO(O)R 23 , OC(O)R 23 , OC(O)R 23 , NH 2 , NHR 23 , N(R 23 ) 2 , NHC(O)R 23 , NR 23 C(O)R 23 , NHS(O) 2 R 23 , NR 23 S(O) 2 R 23 , NHC(O)OR 23 , NR 23 C(O)OR 23 , NHC(O)NH 2 , NHC(O)NHR 23 , NHC(O)N(R 23 ) 2 , NR 23 C(O)NHR 23 , NR 23 C(O)N(R 23 ) 2 , C(O)NH 2 , C(O)NHR 23 , C(O)N(R 23 ) 2 , C(O)NHOH, C(O)NHOR 23 , C(O)NHSO 2 R 23 , C(O)NR 23 SO 2 R 23 SO 2 NH 2 , SO 2 NHR 23 , SO 2 N(R 23 ) 2 , C(O)H, C(O)OH, C(N)NH 2 , C(N)NHR 23 , C(N)N(R 23 ) 2 , CNOH, CNOCH 3 , OH, (O), CN, N 3 , NO 2 , CF 3 , CF 2 CF 3 , OCF 3 , OCF 2 CF 3 , F, Cl, Br or I;
R 23 is alkyl which is unsubstituted or substituted with one or two of independently selected OR 24 ; and
R 24 is hydrogen or alkyl which is unsubstituted or substituted with OH.
2. The compound having Formula I of claim 1 wherein
B 1 is H, OR 1 , NHR 1 or N(R 1 ) 2 ; and
C 1 , D 1 , and E 1 are H.
3. The compound having Formula I of claim 2 wherein A l is NHC(O)R 1 .
4. The compound having Formula I of claim 3 wherein
R 1 is R 2 or R 3 ;
R 2 is phenyl;
R 3 is heteroaryl; wherein each foregoing variable cyclic moiety is unsubstituted or substituted with one or two or three or four or five of independently selected R 12 , OR 12 , C(O)R 12 , CO(O)R 12 , N(R 12 ) 2 , NHS(O) 2 R 12 , C(O)NHR 12 , C(O)N(R 12 ) 2 , SO 2 NH 2 , SO 2 N(R 12 ) 2 , C(O)OH, CN, NO 2 , CF 3 , OCF 3 , F, Cl, Br or I.
5. The compound having Formula I of claim 3 wherein
R 1 is R 5 ;
R 5 is alkyl, which is substituted with one R 6 ;
R 6 is R 7 , R 8 or R 9 ;
R 7 is phenyl which is unfused or fused with benzene or heterocycloalkane;
R 8 is heteroaryl; and
R 9 is cycloalkyl or heterocycloalkyl; wherein each foregoing variable cyclic moiety is independently unsubstituted or substituted with one or two or three or four or five of independently selected R 12 , OR 12 , C(O)R 12 , CO(O)R 12 , N(R 12 ) 2 , NHS(O) 2 R 12 , C(O)NHR 12 , C(O)N(R 12 ) 2 , SO 2 NH 2 , SO 2 N(R 12 ) 2 , C(O)OH, (O), CN, NO 2 , CF 3 , OCF 3 , F, Cl, Br or I.
6. The compound having Formula I of claim 2 wherein A 1 is NHC(O)NHR 1 .
7. The compound having Formula I of claim 6 wherein
R 1 is R 2 or R 3 ;
R 2 is phenyl;
R 3 is heteroaryl; wherein each foregoing variable cyclic moiety is unsubstituted or substituted with one or two or three or four or five of independently selected R 12 , OR 12 , C(O)R 12 , CO(O)R 12 , N(R 12 ) 2 , NHS(O) 2 R 12 , C(O)NHR 12 , C(O)N(R 12 ) 2 , SO 2 NH 2 , SO 2 N(R 12 ) 2 , C(O)OH, CN, NO 2 , CF 3 , OCF 3 , F, Cl, Br or I.
8. The compound having Formula I of claim 2 wherein
F 1 is phenyl which is unsubstituted or substituted with one or two or three or four or five of independently selected R 12 , OR 12 , C(O)R 12 , CO(O)R 12 , N(R 12 ) 2 , NHS(O) 2 R 12 , C(O)NHR 12 , C(O)N(R 12 ) 2 , SO 2 NH 2 , SO 2 N(R 12 ) 2 , C(O)OH, (O), CN, NO 2 , CF 3 , OCF 3 , F, Cl, Br or I.
9. The compound having Formula I of claim 8 wherein the phenyl is substituted with R 12 ,
R 12 is R 15 ; and
R 15 is heterocycloalkyl.
10. The compound having Formula I of claim 2 wherein
F 1 is R 110 ;
R 110 is alkyl which is unsubstituted or substituted with phenyl; wherein the phenyl is unsubstituted or substituted with one or two or three or four or five of independently selected R 12 , OR 12 , C(O)R 12 ,CO(O)R 12 , N(R 12 ) 2 , NHS(O) 2 R 12 , C(O)NHR 12 , C(O)N(R 12 ) 2 , SO 2 NH 2 , SO 2 N(R 12 ) 2 , C(O)OH, (O), CN, NO 2 , CF 3 , OCF 3 , F, Cl, Br or I.
11. The compound having Formula I of claim 1 selected from the group consisting of
N-(3-(5-(2-anilinopyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-chlorobenzamide,
N-(3-(5-(2-anilinopyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
2,6-difluoro-N-(3-(5-(2((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
N-(3-(5-(2((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
N-(3-(5-(2((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
N-(3-(5-(2-((3-fluoro-4-methoxyphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
N-(3-(5-(2-((3-fluoro-4-methoxyphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
N-(3-(5-(2-anilinopyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
N-(3-(5-(2-anilinopyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)acetamide,
N-(3-(5-(2-((3-fluorophenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
N-(3-(5-(2-((3-fluorophenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
N-(3-(5-(2-((3-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
N-(3-(5-(2((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-N′-phenylurea,
N-(3-(5-(2-((4-(4-(3-methoxypropyl)piperazin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
2-(2,6-difluorophenyl)-N-(3-(5-(2((4-(4-(3-methoxypropyl)piperazin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)acetamide,
N-(3-(5-(2-((4-(4-(3-methoxypropyl)piperazin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)acetamide,
2-(2-methoxyphenyl)-N-(3-(5-(2-((4-(4-(3-methoxypropyl)piperazin-1-yl )phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)acetamide,
N-(2-methoxyphenyl)-N′-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)urea,
N-(2-methylphenyl)-N′-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)urea,
N-(3-methylphenyl)-N′-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)urea,
N-(4-methylphenyl)-N′-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)urea,
N-(2-fluorophenyl)-N′-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)urea,
N-(3-fluorophenyl)-N′-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)urea,
N-(4-fluorophenyl)-N′-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)urea,
N-(2-chlorophenyl)-N′-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)urea,
N-(3-chlorophenyl)-N′-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)urea,
N-(4-chlorophenyl)-N′-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)urea,
N-(3-methoxyphenyl)-N′-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)urea,
N-(4-methoxyphenyl)-N′-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)urea,
N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-N′-(2-(trifluoromethyl)phenyl)urea,
N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-N′-(3-(trifluoromethyl)phenyl)urea,
N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-N′-(4-(trifluoromethyl)phenyl)urea,
N-(3-(5-(2-aminopyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
N-(3-(5-(2-((3-(acetylamino)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
N-(3-(5-(2-((3-(acetylamino)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
N-(3-(5-(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
N-(3-(5-(2-((3-chlorophenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
N-(3-(5-(2-((3-methylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
N-(3-(5-(2-((3-methoxyphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
N-(3-(5-(2-((4-(1H-imidazol-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
N-(3-(5-(2-((4-(1H-imidazol-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylbutanamide,
N-(3-(5-(2-((4-(1,1-dioxidothiomorpholin-4-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
N-(3-(5-(2-((4-(1,1-dioxidothiomorpholin-4-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-(3-methoxyphenyl)acetamide,
N-(3-(5-(2-((4-(1,1-dioxidothiomorpholin-4-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-(4-methoxyphenyl)acetamide,
N-benzyl-N′-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)urea,
N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-thien-2-ylacetamide,
phenyl 3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenylcarbamate,
N-(3-(5-(2-((3-((methylsulfonyl)amino)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
3-(1H-imidazol-4-yl)-N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)propanamide,
ethyl 3-((4-(6-(3-((phenylacetyl)amino)phenyl)imidazo[2,1-b][1,3]thiazol-5-yl)pyrimidin-2-yl)amino)benzoate,
benzyl 3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo [2,1 -b][1,3]thiazol-6-yl)phenylcarbamate,
4-methoxyphenyl 3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo [2,1-b][1,3 ]thiazol-6-yl)phenylcarbamate,
N-(3-(5-(2-((3-methylphenyl)amino)pyrimidin-4-yl)imidazo[2, 1-b][1,3 ]thiazol-6-yl)phenyl)benzamide,
N-(3-(5-(2-((4-methylphenyl)amino)pyrimidin-4-yl)imidazo[2, 1-b][1,3 ]thiazol-6-yl)phenyl)benzamide,
N-(3-(5-(2-((4-methylphenyl)amino)pyrimidin-4-yl)imidazo[2, 1-b][1,3 ]thiazol-6-yl)phenyl)-2-phenylacetamide,
N-(3-(5-(2-((4-methylphenyl)amino)pyrimidin-4-yl)imidazo[2, 1-b][1,3 ]thiazol-6-yl)phenyl)benzamide,
N-(3-(5-(2-((2-chlorophenyl)amino)pyrimidin-4-yl)imidazo [2,1-b][1,3 ]thiazol-6-yl)phenyl)benzamide,
N-(3-(5-(2-((4-chlorophenyl)amino)pyrimidin-4-yl)imidazo [2,1-b][1,3 ]thiazol-6-yl)phenyl)benzamide,
N-(3-(5-(2-((4-chlorophenyl)amino)pyrimidin-4-yl)imidazo [2,1-b][1,3 ]thiazol-6-yl)phenyl)-2-phenylacetamide,
3-((4-(6-(3-((phenylacetyl)amino)phenyl)imidazo [2,1-b][1,3 ]thiazol-5-yl)pyrimidin-2-yl)amino)benzoic acid,
N-(3-(5-(2-((2-methylphenyl)amino)pyrimidin-4-yl)imidazo[2, 1-b][1,3 ]thiazol-6-yl)phenyl)-2-phenylacetamide,
N-(3-(5-(2-((2-chlorophenyl)amino)pyrimidin-4-yl)imidazo [2,1-b][1,3 ]thiazol-6-yl)phenyl)-2-phenylacetamide,
N-(3-(5-(2-((4-(4-acetylpiperazin- 1 -yl)phenyl)amino)pyrimidin-4-yl)imidazo [2,1 -b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
benzyl 3-(5-(2-((4-(4-acetylpiperazin- 1 -yl)phenyl)amino)pyrimidin-4-yl)imidazo [2,1 -b][1,3]thiazol-6-yl)phenylcarbamate,
N-(3-(5-(2-((4-(2-oxopyrrolidin- 1 -yl)phenyl)amino)pyrimidin-4-yl)imidazo [2,1 -b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
benzyl 3-(5-(2-((4-(2-oxopyrrolidin- 1 -yl)phenyl)amino)pyrimidin-4-yl)imidazo [2,1 -b][1,3]thiazol-6-yl)phenylcarbamate,
2-(2-methylphenyl)-N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)acetamide,
2-(3-methylphenyl)-N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)acetamide,
2-(4-methylphenyl)-N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)acetamide,
N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-(2-nitrophenyl)acetamide,
2-(2-fluorophenyl)-N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)acetamide,
2-(2-chlorophenyl)-N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)acetamide,
2-(3-chlorophenyl)-N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)acetamide,
2-(4-chlorophenyl)-N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)acetamide,
2-(2-bromophenyl)-N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)acetamide,
2-(3-bromophenyl)-N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)acetamide,
2-(4-bromophenyl)-N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)acetamide,
N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-(3-nitrophenyl)acetamide,
N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-(4-nitrophenyl)acetamide,
2-(1,1′-biphenyl-4-yl)-N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)acetamide,
2-(4-(dimethylamino)phenyl)-N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)acetamide,
N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-(3-(trifluoromethyl)phenyl)acetamide,
N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-(4-(trifluoromethyl)phenyl)acetamide,
N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-(3-(trifluoromethoxy)phenyl)acetamide,
N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-(4-phenoxyphenyl)acetamide,
2-(4-(benzyloxy)phenyl)-N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)acetamide,
N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-(1-naphthyl)acetamide,
N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-(2-naphthyl)acetamide,
2-(2,5-dimethylphenyl)-N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)acetamide,
2-mesityl-N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)acetamide,
2-(3,5-dimethylphenyl)-N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)acetamide,
2-(2,3-dimethoxyphenyl)-N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)acetamide,
2-(2,4-dimethoxyphenyl)-N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)acetamide,
2-(2,5-dimethoxyphenyl)-N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)acetamide,
2-(3,4-dimethoxyphenyl)-N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)acetamide,
2-(3,5-dimethoxyphenyl)-N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)acetamide,
2-(1,3-benzodioxo1-5-yl)-N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)acetamide,
N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-(3,4,5-trimethoxyphenyl)acetamide,
2-(2,3-difluorophenyl)-N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)acetamide,
2-(2,4-dichlorophenyl)-N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)acetamide,
2-(2,5-difluorophenyl)-N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)acetamide,
2-(3,4-dichlorophenyl)-N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)acetamide,
2-(2,6-dichlorophenyl)-N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)acetamide,
N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-furamide,
N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-3-furamide,
2,5-dimethyl-N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-3-furamide,
N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)thiophene-2-carboxamide,
N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)thiophene-3-carboxamide,
3-methyl-N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)thiophene-2-carboxamide,
5-methyl-N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)thiophene-2-carboxamide,
N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-1H-pyrrole-2-carboxamide,
1-methyl-N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-1H-pyrrole-2-carboxamide,
N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-1,3-thiazole-4-carboxamide,
N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-1,3-thiazole-5-carboxamide,
N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-1H-pyrazole-4-carboxamide,
3,5-dimethyl-N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)isoxazole-4-carboxamide,
5-methyl-N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-3-phenylisoxazole-4-carboxamide,
N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)pyridine-2-carboxamide,
N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)nicotinamide,
N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)isonicotinamide,
N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-pyridin-2-ylacetamide,
N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-pyridin-3-ylacetamide,
N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-pyridin-4-ylacetamide,
N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)pyrazine-2-carboxamide,
N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)pyrimidine-4-carboxamide,
5-methyl-N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)pyrazine-2-carboxamide,
N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-1H-indole-3-carboxamide,
5-methyl-N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-1-phenyl-1H-pyrazole-4-carboxamide,
N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-4-oxo-4,5,6,7-tetrahydro-1-benzofuran-3-carboxamide,
N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-pyrrolidin-1-ylacetamide,
N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-3-piperidin-1-ylpropanamide,
2-(4-methylpiperazin-1-yl)-N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)acetamide,
2-cyclopentyl-N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)acetamide,
N-(4-(4-acetylpiperazin-1-yl)phenyl)-4-(6-(3-((5-phenyl-1,3,4-oxadiazol-2-yl)amino)phenyl)imidazo[2,1-b][1,3]thiazol-5-yl)pyrimidin-2-amine,
N-(3-(5-(2-((4-(4-acetylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
N-(3-(5-(2-((4-(2-oxopyrrolidin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
2-cyclohexyl-N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)acetamide,
2-chlorobenzyl 3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenylcarbamate,
N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-1,3-benzoxazol-2-amine,
5-methyl-N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-1,3-benzoxazol-2-amine,
6-chloro-N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-1,3-benzoxazol-2-amine,
N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-1H-indazol-3-amine,
N-(3-(5-(2-((4-((dimethylamino)sulfonyl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
N-(3-(5-(2-((3-(2-morpholin-4-ylethoxy)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
N-(3-(5-(2-((3-(2-morpholin-4-ylethoxy)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
2-(2-methoxyphenyl)-N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)acetamide,
N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-(2-(trifluoromethyl)phenyl)acetamide,
N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-(2-(trifluoromethoxy)phenyl)acetamide,
2-(2-fluoro-3-(trifluoromethyl)phenyl)-N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)acetamide,
2-(2,6-difluorophenyl)-N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)acetamide,
N-(3-(5-(2-((3-(3-(4-methylpiperazin-1-yl)propoxy)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
N-(3-(5-(2-((3-(3-(4-methylpiperazin-1-yl)propoxy)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
N-(3-(5-(2-((3-(3-morpholin-4-ylpropoxy)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
N-(3-(5-(2-((3-(3-morpholin-4-ylpropoxy)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
N-(3-(5-(2-((4-(4-(3-methoxypropyl)piperazin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
2,6-difluoro-N-(3-(5-(2-((4-(4-(3-methoxypropyl)piperazin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
N-(2-morpholin-4-ylethyl)-3-((4-(6-(3-((phenylacetyl)amino)phenyl)imidazo[2,1-b][1,3]thiazol-5-yl)pyrimidin-2-yl)amino)benzamide,
N-(2-isopropoxyethyl)-3-((4-(6-(3-((phenylacetyl)amino)phenyl)imidazo[2,1-b][1,3]thiazol-5-yl)pyrimidin-2-yl)amino)benzamide,
3-((4-(6-(3-((phenylacetyl)amino)phenyl)imidazo[2,1-b][1,3]thiazol-5-yl)pyrimidin-2-yl)amino)-N-(3-propoxypropyl)benzamide,
N-(3-methoxypropyl)-3-((4-(6-(3-((phenylacetyl)amino)phenyl)imidazo[2,1-b][1,3]thiazol-5-yl)pyrimidin-2-yl)amino)benzamide,
3-((4-(6-(3-((phenylacetyl)amino)phenyl)imidazo[2,1-b][1,3]thiazol-5-yl)pyrimidin-2-yl)amino)-N-((2S)-tetrahydrofuran-2-ylmethyl)benzamide,
N,N-bis(2-ethoxyethyl)-3-((4-(6-(3-((phenylacetyl)amino)phenyl)imidazo[2,1-b][1,3]thiazol-5-yl)pyrimidin-2-yl)amino)benzamide,
N-(2-methoxyethyl)-N-methyl-3-((4-(6-(3-((phenylacetyl)amino)phenyl)imidazo[2,1-b][1,3]thiazol-5-yl)pyrimidin-2-yl)amino)benzamide,
N-ethyl-N-(2-methoxyethyl)-3-((4-(6-(3-((phenylacetyl)amino)phenyl)imidazo[2,1-b][1,3]thiazol-5-yl)pyrimidin-2-yl)amino)benzamide,
N,N-bis(2-methoxyethyl)-3-((4-(6-(3-((phenylacetyl)amino)phenyl)imidazo[2,1-b][1,3]thiazol-5-yl)pyrimidin-2-yl)amino)benzamide,
N-(3-(5-(2-((3-(morpholin-4-ylcarbonyl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
2-phenyl-N-(3-(5-(2-((3-(thiomorpholin-4-ylcarbonyl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)acetamide,
N-(2-(dimethylamino)ethyl)-3-((4-(6-(3-((phenylacetyl)amino)phenyl)imidazo[2,1-b][1,3]thiazol-5-yl)pyrimidin-2-yl)amino)benzamide,
3-((4-(6-(3-((phenylacetyl)amino)phenyl)imidazo[2,1-b][1,3]thiazol-5-yl)pyrimidin-2-yl)amino)-N-(2-pyrrolidin-1-ylethyl)benzamide,
3-((4-(6-(3-((phenylacetyl)amino)phenyl)imidazo[2,1-b][1,3]thiazol-5-yl)pyrimidin-2-yl)amino)-N-(2-piperidin-1-ylethyl)benzamide,
N-(3-morpholin-4-ylpropyl)-3-((4-(6-(3-((phenylacetyl)amino)phenyl)imidazo[2,1-b][1,3]thiazol-5-yl)pyrimidin-2-yl)amino)benzamide,
N-(2-(4-methylpiperazin-1-yl)ethyl)-3-((4-(6-(3-((phenylacetyl)amino)phenyl)imidazo[2,1-b][1,3]thiazol-5-yl)pyrimidin-2-yl)amino)benzamide,
N-methyl-3-((4-(6-(3-((phenylacetyl)amino)phenyl)imidazo[2,1-b][1,3]thiazol-5-yl)pyrimidin-2-yl)amino)-N-(tetrahydrofuran-2-ylmethyl)benzamide,
N-(3-(dimethylamino)propyl)-N-methyl-3-((4-(6-(3-((phenylacetyl)amino)phenyl)imidazo[2,1-b][1,3]thiazol-5-yl)pyrimidin-2-y1)amino)benzamide,
N-(2-(dimethylamino)ethyl)-N-ethyl-3-((4-(6-(3-((phenylacetyl)amino)phenyl)imidazo[2,1-b][1,3]thiazol-5-yl)pyrimidin-2-yl)amino)benzamide,
N-methyl-3-((4-(6-(3-((phenylacetyl)amino)phenyl)imidazo[2,1-b][1,3]thiazol-5-yl)pyrimidin-2-yl)amino)-N-(2-pyridin-2-ylethyl)benzamide,
N-(3-(5-(2-((3-((2,6-dimethylmorpholin-4-yl)carbonyl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
N-(3-(5-(2-((3-((4-methylpiperazin-1-yl)carbonyl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
N-(3-(5-(2-((3-((4-ethylpiperazin-1-yl)carbonyl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
N-(3-(5-(2-((3-((4-(2-hydroxyethyl)piperazin-1-yl)carbonyl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
N-(3-(5-(2-((3-((4-(2-(2-hydroxyethoxy)ethyl)piperazin-1-yl)carbonyl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
N-(4-(dimethylamino)butyl)-3-((4-(6-(3-((phenylacetyl)amino)phenyl)imidazo[2,1-b][1,3]thiazol-5-yl)pyrimidin-2-yl)amino)benzamide,
N-(3-(1H-imidazol-1-yl)propyl)-3-((4-(6-(3-((phenylacetyl)amino)phenyl)imidazo[2,1-b][1,3]thiazol-5-yl)pyrimidin-2-y1)amino)benzamide,
2-fluoro-N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
2-methyl-N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
4-(6-(3-((5-(4-methoxyphenyl)-1,3-oxazol-2-yl)amino)phenyl)imidazo[2,1-b][1,3]thiazol-5-yl)-N-(4-morpholin-4-ylphenyl)pyrimidin-2-amine,
N-(4-morpholin-4-ylphenyl)-4-(6-(3-((5-phenyl-1,3-oxazol-2-yl)amino)phenyl)imidazo[2,1-b][1,3]thiazol-5-yl)pyrimidin-2-amine,
N-(3-(2-bromo-5-(2-((3-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
N-(3-(2-bromo-5-(2-((3-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
2-methoxy-N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
2-chloro-N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
2,6-dimethoxy-N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
2-chloro-6-fluoro-N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
2,6-dichloro-N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-nitrobenzamide,
N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-(trifluoromethyl)benzamide,
2,5-dichloro-N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)thiophene-3-carboxamide,
N-(3-(5-(2-((4-(4-ethylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
2-(2-chlorophenyl)-N-(3-(5-(2-((4-(4-ethylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)acetamide,
N-(3-(5-(2-((4-(4-ethylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-(2-methylphenyl)acetamide,
N-(3-(5-(2-((4-(4-ethylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-(2-(trifluoromethyl)phenyl)acetamide,
N-(3-(5-(2-((4-(4-ethylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
N-(3-(5-(2-((4-(4-ethylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2,6-difluorobenzamide,
2-chloro-N-(3-(5-(2-((4-(4-ethylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-6-fluorobenzamide,
2-chloro-N-(3-(5-(2-((4-(4-ethylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
2,6-dichloro-N-(3-(5-(2-((4-(4-ethylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
N-(4-(4-ethylpiperazin-1-yl)phenyl)-4-(6-(3-((5-phenyl-1,3,4-oxadiazol-2-yl)amino)phenyl)imidazo[2,1-b][1,3]thiazol-5-yl)pyrimidin-2-amine,
N-(4-(4-ethylpiperazin-1-yl)phenyl)-4-(6-(3-((5-phenyl-1,3-oxazol-2-yl)amino)phenyl)imidazo[2,1-b][1,3]thiazol-5-yl)pyrimidin-2-amine,
N-(3-(2-bromo-5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
N-(3-(2-bromo-5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
2-phenyl-N-(3-(5-(2-((3-(3-pyrrolidin-1-ylpropoxy)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)acetamide,
N-(3-(5-(2-((3-(morpholin-4-ylsulfonyl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-1-phenylcyclopropanecarboxamide,
2-methyl-N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylpropanamide,
N-(2-morpholin-4-ylethyl)-4-((4-(6-(3-((phenylacetyl)amino)phenyl)imidazo[2,1-b][1,3]thiazol-5-yl)pyrimidin-2-yl)amino)benzamide,
3-cyanobenzyl 3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenylcarbamate,
3-methylbenzyl 3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenylcarbamate,
3-chlorobenzyl 3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenylcarbamate,
3-methoxybenzyl 3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenylcarbamate,
3-fluorobenzyl 3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenylcarbamate,
4-fluorobenzyl 3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenylcarbamate,
4-methylbenzyl 3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenylcarbamate,
3,5-difluorobenzyl 3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenylcarbamate,
3-(benzyloxy)benzyl 3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenylcarbamate,
1,3-benzodioxo1-5-ylmethyl 3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenylcarbamate,
N-(3-(5-(2-((3-((dimethylamino)sulfonyl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
N-(3-(5-(2-((3-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-N′-phenylurea,
N-(2-methylphenyl)-N′-(3-(5-(2-((3-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)urea,
N-(2-fluorophenyl)-N′-(3-(5-(2-((3-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)urea,
N-(3-(5-(2-((4-(4-ethylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-1-phenylcyclopropanecarboxamide,
N-(3-(5-(2-((3-(3-morpholin-4-ylpropoxy)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-N′-phenylurea,
N-(2-methylphenyl)-N′-(3-(5-(2-((3-(3-morpholin-4-ylpropoxy)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)urea,
N-(2-fluorophenyl)-N′-(3-(5-(2-((3-(3-morpholin-4-ylpropoxy)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)urea,
N-(3-(5-(2-((3-(3-(4-methylpiperazin-1-yl)propoxy)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-N′-phenylurea,
N-(2-methylphenyl)-N′-(3-(5-(2-((3-(3-(4-methylpiperazin-1-y1)propoxy)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)urea,
N-(2-fluorophenyl)-N′-(3-(5-(2-((3-(3-(4-methylpiperazin-1-y1)propoxy)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)urea,
N-(3-(5-(2-((3-(aminosulfonyl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
N-(3-(5-(2-((4-(aminosulfonyl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
N-(3-(5-(2-((3-(((2-morpholin-4-ylethyl)amino)sulfonyl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
trans-2-phenyl-N-(3-(5-(2-((4-piperidin-1-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)cyclopropanecarboxamide,
3-phenyl-N-(3-(5-(2-((4-piperidin-1-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)propanamide,
2-phenyl-N-(3-(5-(2-((4-piperidin-1-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)acetamide,
N-(3-(5-(2-((4-piperidin-1-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
N-(3-(5-(2-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
N-(3-(5-(2-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
trans-2-phenyl-N-(3-(5-(2-((4-pyrrolidin-1-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)cyclopropanecarboxamide,
N-(3-(5-(2-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-3-phenylpropanamide,
3-phenyl-N-(3-(5-(2-((4-pyrrolidin-1-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)propanamide,
trans-N-(3-(5-(2-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylcyclopropanecarboxamide,
N-(3-(5-(2-((4-(4-isopropylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
2-phenyl-N-(3-(5-(2-((4-pyrrolidin-1-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)acetamide,
N-(3-(5-(2-((4-(4-isopropylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
N-(3-(5-(2-((4-(4-isopropylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-3-phenylpropanamide,
N-(3-(5-(2-((4-pyrrolidin-1-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
trans-N-(3-(5-(2-((4-(4-isopropylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylcyclopropanecarboxamide,
2-(2-chlorophenyl)-N-(3-(5-(2-((4-(4-isopropylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)acetamide,
2-chloro-N-(3-(5-(2-((4-(4-isopropylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
N-(3-(5-(2-((3-(acetylamino)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2,6-difluorobenzamide,
N-(3-(5-(2-((4-(4-(3-methoxypropyl)piperazin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-N′-phenylurea,
N-(2-chlorophenyl)-N′-(3-(5-(2-((4-(4-(3-methoxypropyl)piperazin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)urea,
N-(3-((4-(6-(3-((anilinocarbonyl)amino)phenyl)imidazo[2,1-b][1,3]thiazol-5-yl)pyrimidin-2-yl)amino)phenyl)acetamide,
N-(3-((4-(6-(3-((((2-chlorophenyl)amino)carbonyl)amino)phenyl)imidazo[2,1-b][1,3]thiazol-5-yl)pyrimidin-2-yl)amino)phenyl)acetamide,
N-(3-(5-(2-((3-(acetylamino)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-(2-chlorophenyl)acetamide,
2-(2-chlorophenyl)-N-(3-(5-(2-((4-(4-(3-methoxypropyl)piperazin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)acetamide,
N-(3-(5-(2-((4-(4-acetylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-(2-chlorophenyl)acetamide,
N-(3-(5-(2-((4-(4-acetylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2,6-difluorobenzamide,
N-(3-(5-(2-((4-(4-acetylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-chlorobenzamide,
N-(3-(5-(2-((4-(4-acetylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-N′-phenylurea,
N-(3-(5-(2-((4-(4-acetylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-N′-(2-chlorophenyl)urea,
2,6-difluoro-N-(3-(5-(2-((4-(4-isopropylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
N-(3-(5-(2-((4-(4-isopropylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-N′-phenylurea,
N-(2-chlorophenyl)-N′-(3-(5-(2-((4-(4-isopropylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)urea,
2-(5-acetylthien-3-yl)-N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)acetamide,
2-methyl-N-(3-(5-(2-((3-(2-morpholin-4-ylethyl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
2-fluoro-N-(3-(5-(2-((3-(2-morpholin-4-ylethyl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
2,6-difluoro-N-(3-(5-(2-((3-(2-morpholin-4-ylethyl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
N-(3-(5-(2-((3-(2-morpholin-4-ylethyl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-N′-phenylurea,
N-(3-(5-(2-((3-(2-morpholin-4-ylethyl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
N-(3-(5-(2-((3-(2-oxopyrrolidin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
2-(2-chlorophenyl)-N-(3-(5-(2-((3-(2-oxopyrrolidin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)acetamide,
N-(3-(5-(2-((3-(2-oxopyrrolidin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
2-chloro-N-(3-(5-(2-((3-(2-oxopyrrolidin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
2,6-difluoro-N-(3-(5-(2-((3-(2-oxopyrrolidin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
2-(2-chlorophenyl)-N-(3-(5-(2-((3-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)acetamide,
N-(3-(5-(2-((3-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
2,6-difluoro-N-(3-(5-(2-((3-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
N-(2-chlorophenyl)-N′-(3-(5-(2-((3-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)urea,
N-(3-(5-(2-((3-(2-pyrrolidin-1-ylethoxy)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
2-phenyl-N-(3-(5-(2-((3-(2-pyrrolidin-1-ylethoxy)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)acetamide,
2,6-difluoro-N-(3-(5-(2-((3-(3-morpholin-4-ylpropoxy)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
N-(2-chlorophenyl)-N′-(3-(5-(2-((3-(3-morpholin-4-ylpropoxy)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)urea,
2-(2-chlorophenyl)-N-(3-(5-(2-((3-(3-morpholin-4-ylpropoxy)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)acetamide,
3-((4-(6-(3-(benzoylamino)phenyl)imidazo[2,1-b][1,3]thiazol-5-yl)pyrimidin-2-yl)amino)-N-(2-(dimethylamino)ethyl)benzamide,
N-(3-(5-(2-((3-(((2-(dimethylamino)ethyl)amino)carbonyl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2,6-difluorobenzamide,
3-((4-(6-(3-((anilinocarbonyl)amino)phenyl)imidazo[2,1-b][1,3]thiazol-5-yl)pyrimidin-2-yl)amino)-N-(2-(dimethylamino)ethyl)benzamide,
3-((4-(6-(3-((((2-chlorophenyl)amino)carbonyl)amino)phenyl)imidazo[2,1-b][1,3]thiazol-5-yl)pyrimidin-2-yl)amino)-N-(2-(dimethylamino)ethyl)benzamide,
N-(2-chloro-5-(5-(2-((3-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
N-(2-(dimethylamino)-5-(5-(2-((3-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
N-(2-chloro-5-(5-(2-((3-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
N-(2-(dimethylamino)-5-(5-(2-((3-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
N-(2-ethoxy-5-(5-(2-((3-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
N-(3-(5-(2-((4-(4-(3-hydroxypropyl)piperazin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
N-(3-(5-(2-((4-(4-(3-hydroxypropyl)piperazin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
3-((4-(6-(3-(((2-chlorophenyl)acetyl)amino)phenyl)imidazo[2,1-b][1,3]thiazol-5-yl)pyrimidin-2-yl)amino)-N-(2-(dimethylamino)ethyl)benzamide,
N-(2-ethoxy-5-(5-(2-((3-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
2,6-difluoro-N-(3-(5-(2-((3-(3-(4-methylpiperazin-1-yl)propoxy)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
N-(2-chlorophenyl)-N′-(3-(5-(2-((3-(3-(4-methylpiperazin-1-y1)propoxy)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)urea,
2-(2-chlorophenyl)-N-(3-(5-(2-((3-(3-(4-methylpiperazin-1-y1)propoxy)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)acetamide,
N-(3-(5-(2-((3-(4-isopropylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
N-(3-(5-(2-((3-(4-isopropylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
2-(2-chlorophenyl)-N-(3-(5-(2-((3-(4-isopropylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)acetamide,
2-chloro-N-(3-(5-(2-((3-(4-isopropylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
2,6-difluoro-N-(3-(5-(2-((3-(4-isopropylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
N-(3-(5-(2-((3-(4-ethylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
N-(3-(5-(2-((3-(4-ethylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
N-(3-(5-(2-((3-(4-ethylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2,6-difluorobenzamide,
2-phenyl-N-(3-(5-(2-(pyridin-4-ylamino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-y1)phenyl)acetamide,
N-(3-(5-(2-((4-(4-ethyl-2-oxopiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
N-(3-(5-(2-((4-(4-ethyl-2-oxopiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
2-chloro-N-(3-(5-(2-((4-(4-ethyl-2-oxopiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
N-(3-(5-(2-((4-(4-ethyl-2-oxopiperazin- 1 -yl)phenyl)amino)pyrimidin-4-yl)imidazo [2,1-b][1,3 ]thiazol-6-yl)phenyl)-2,6-difluorobenzamide,
2-chloro-N-(3-(5-(2-((4-(4-ethyl-2-oxopiperazin- 1 -yl)phenyl)amino)pyrimidin-4-yl)imidazo [2,1-b][1,3 ]thiazol-6-yl)phenyl)-4-fluorobenzamide,
N-(3-(5-(2-((3-(4-ethyl-2-oxopiperazin- 1 -yl)phenyl)amino)pyrimidin-4-yl)imidazo [2,1-b][1,3 ]thiazol-6-yl)phenyl)-2-phenylacetamide,
N-(3-(5-(2-((3-(4-ethyl-2-oxopiperazin- 1 -yl)phenyl)amino)pyrimidin-4-yl)imidazo [2,1-b][1,3 ]thiazol-6-yl)phenyl)benzamide,
2-chloro-N-(3-(5-(2-((3-(4-ethyl-2-oxopiperazin- 1 -yl)phenyl)amino)pyrimidin-4-yl)imidazo [2,1-b][1,3 ]thiazol-6-yl)phenyl)benzamide,
N-(3-(5-(2-((3-(4-ethyl-2-oxopiperazin- 1 -yl)phenyl)amino)pyrimidin-4-yl)imidazo [2,1-b][1,3 ]thiazol-6-yl)phenyl)-2,6-difluorobenzamide,
2-chloro-N-(3-(5-(2-((3-(4-ethyl-2-oxopiperazin- 1 -yl)phenyl)amino)pyrimidin-4-yl)imidazo [2,1-b][1,3 ]thiazol-6-yl)phenyl)-4-fluorobenzamide,
2-chloro-4-fluoro-N-(3-(5-(243 -(2-oxopyrrolidin- 1 -yl)phenyl)amino)pyrimidin-4-yl)imidazo [2,1-b][1,3 ]thiazol-6-yl)phenyl)benzamide,
N-(3-(5-(2-((3-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)imidazo [2,1-b][1,3 ]thiazol-6-yl)phenyl)-2-phenylacetamide,
N-(3-(5-(2-((3-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)imidazo [2,1-b][1,3 ]thiazol-6-yl)phenyl)benzamide,
N-(3-(2-methyl-5-(243 -morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2, 1-b][1,3 ]thiazol-6-yl)phenyl)benzamide,
N-(3-(2-methyl-5-(243 -morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2, 1-b][1,3 ]thiazol-6-yl)phenyl)-2-phenylacetamide,
N-(3-(2-methyl-5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2, 1-b][1,3 ]thiazol-6-yl)phenyl)benzamide,
2-phenyl-N-(3-(5-(2-(1H-pyrazol-5-ylamino)pyrimidin-4-yl)imidazo [2,1-b][1,3 ]thiazol-6-yl)phenyl)acetamide,
N-(3-(5-(2-((4-(methylsulfonyl)phenyl)amino)pyrimidin-4-yl)imidazo [2,1-b][1,3 ]thiazol-6-yl)phenyl)benzamide,
2,6-difluoro-N-(3-(5-(2-((4-(methylsulfonyl)phenyl)amino)pyrimidin-4-yl)imidazo [2,1-b][1,3 ]thiazol-6-yl)phenyl)benzamide,
N-(3-(5-(2-((4-(methylsulfonyl)phenyl)amino)pyrimidin-4-yl)imidazo [2,1-b][1,3 ]thiazol-6-yl)phenyl)-2-phenylacetamide,
N-(3-(5-(2-((3-tert-butyl- 1 H-pyrazol-5-yl)amino)pyrimidin-4-yl)imidazo [2,1 -b][1,3 ]thiazol-6-yl)phenyl)-N′-phenylurea,
N-(3-(5-(2-((3-tert-butyl- 1 H-pyrazol-5-yl)amino)pyrimidin-4-yl)imidazo [2,1 -b][1,3 ]thiazol-6-yl)phenyl)-2-phenylacetamide,
N-(3-(5-(2-((3-(((2-(methylsulfonyl)ethyl)amino)methyl)phenyl)amino)pyrimidin-4-yl)imidazo [2,1-b][1,3 ]thiazol-6-yl)phenyl)benzamide,
2,6-difluoro-N-(3-(5-(2-((3-(((2-(methylsulfonyl)ethyl)amino)methyl)phenyl)amino)pyrimidin-4-yl)imidazo [2,1 -b][1,3 ]thiazol-6-yl)phenyl)benzamide,
N-(3-(5-(2-((3-(((2-(methylsulfonyl)ethyl)amino)methyl)phenyl)amino)pyrimidin-4-yl)imidazo [2,1-b][1,3 ]thiazol-6-yl)phenyl)-2-phenylacetamide,
N-(3-(5-(2-((3-tert-butyl- 1 H-pyrazol-5-yl)amino)pyrimidin-4-yl)imidazo [2,1 -b][1,3 ]thiazol-6-yl)phenyl)benzamide,
2-phenyl-N-(3-(5-(2-((3-pyridin-3-yl-1 H-pyrazol-5-yl)amino)pyrimidin-4-yl)imidazo [2,1-b][1,3 ]thiazol-6-yl)phenyl)acetamide,
4-(6-(3-(benzylamino)phenyl)imidazo[2, 1-b][1,3 ]thiazol-5-yl)-N-(3-(3-morpholin-4-ylpropoxy)phenyl)pyrimidin-2-amine,
N-(4-morpholin-4-ylphenyl)-4-(6-(3-((thien-2-ylmethyl)amino)phenyl)imidazo [2,1-b][1,3 ]thiazol-5-yl)pyrimidin-2-amine,
4-(6-(3-((2-chlorobenzyl)amino)phenyl)imidazo [2,1-b][1,3 ]thiazol-5-yl)-N-(4-morpholin-4-ylphenyl)pyrimidin-2-amine,
4-(6-(3-((3-methylbenzyl)amino)phenyl)imidazo [2,1-b][1,3 ]thiazol-5-yl)-N-(4-morpholin-4-ylphenyl)pyrimidin-2-amine,
4-(6-(3-((4-methylbenzyl)amino)phenyl)imidazo [2,1-b][1,3 ]thiazol-5-yl)-N-(4-morpholin-4-ylphenyl)pyrimidin-2-amine,
4-(6-(3-((4-chlorobenzyl)amino)phenyl)imidazo [2,1-b][1,3 ]thiazol-5-yl)-N-(4-morpholin-4-ylphenyl)pyrimidin-2-amine,
4-(6-(3-((3-chlorobenzyl)amino)phenyl)imidazo [2,1-b][1,3 ]thiazol-5-yl)-N-(4-morpholin-4-ylphenyl)pyrimidin-2-amine,
4-(6-(3-((3-methoxybenzyl)amino)phenyl)imidazo [2,1-b][1,3 ]thiazol-5-yl)-N-(4-morpholin-4-ylphenyl)pyrimidin-2-amine,
2-(((3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)amino)methyl)benzonitrile,
N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyridin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyridin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
N-(3-(4-isopropylpiperazin-1-yl)phenyl)-4-(6-(3-((5-phenyl-1,3,4-oxadiazol-2-yl)amino)phenyl)imidazo[2,1-b][1,3]thiazol-5-yl)pyrimidin-2-amine,
N-(3-(5-(2-((1-benzoyl-3-tert-butyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
4-(6-(3-(1-methyl-1H-imidazol-2-yl)phenyl)imidazo[2,1-b][1,3]thiazol-5-yl)-N-(3-morpholin-4-ylphenyl)pyrimidin-2-amine,
N-(2-chloro-3-(5-(2-((3-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2,6-difluorobenzamide,
N-(2-chloro-3-(5-(2-((3-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-fluorobenzamide,
N-(2-chloro-3-(5-(2-((3-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
N-(2-(dimethylamino)-3-(5-(2-((3-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2,6-difluorobenzamide,
N-(2-(dimethylamino)-3-(5-(2-((3-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
2,6-difluoro-N-(3-(5-(2-((3-((4-methylpiperazin-1-yl)methyl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
2-fluoro-N-(3-(5-(2-((3-((4-methylpiperazin-1-yl)methyl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
N-(3-(5-(2-((3-((4-methylpiperazin-1-yl)methyl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
N-(3-(5-(2-((3-((dimethylamino)methyl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2,6-difluorobenzamide,
N-(3-(5-(2-((3-((dimethylamino)methyl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-fluorobenzamide,
N-(3-(5-(2-((3-((dimethylamino)methyl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
2-chloro-N-(3-(5-(2-((3-((dimethylamino)methyl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
N-(3-(5-(2-((3-((dimethylamino)methyl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-N′-phenylurea,
2,6-difluoro-N-(3-(5-(2-((3-(morpholin-4-ylmethyl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
2-fluoro-N-(3-(5-(2-((3-(morpholin-4-ylmethyl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
N-(3-(5-(2-((3-(morpholin-4-ylmethyl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
2-chloro-N-(3-(5-(2-((3-(morpholin-4-ylmethyl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
N-(3-(5-(2-((3-(morpholin-4-ylmethyl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-N′-phenylurea,
4-(6-(3-((5-methyl-1,3,4-thiadiazol-2-yl)amino)phenyl)imidazo[2,1-b][1,3]thiazol-5-y1)-N-(4-morpholin-4-ylphenyl)pyrimidin-2-amine,
4-(6-(3-((5-methyl-1,3,4-thiadiazol-2-yl)amino)phenyl)imidazo[2,1-b][1,3]thiazol-5-yl)-N-(3-morpholin-4-ylphenyl)pyrimidin-2-amine,
4-(6-(3-((5-methyl-1,3,4-thiadiazol-2-yl)amino)phenyl)imidazo[2,1-b][1,3]thiazol-5-y1)-N-(4-pyrrolidin-1-ylphenyl)pyrimidin-2-amine,
3-(5-(2-((3-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)benzaldehyde 0-phenyloxime,
3-(5-(2-((3-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)benzaldehyde O-benzyloxime,
3-(5-(2-((3-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)benzaldehyde 0-ethyloxime,
N′-(benzoyloxy)-3-(5-(2-((3-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)benzenecarboximidamide,
N-(3-(5-(2-((3-(methylsulfonyl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
2,6-difluoro-N-(3-(5-(2-((3-(methylsulfonyl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
N-(3-(5-(2-((3-(methylsulfonyl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
N-(3-(5-(2-((3-(4-acetylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
N-(3-(5-(2-((3-(4-acetylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
N-(3-(5-(2-((3-(4-acetylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-chlorobenzamide,
N-(3-(5-(2-((3-(4-acetylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2,6-difluorobenzamide,
2,6-difluoro-N-(3-(5-(2-((3-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
N-(3-(5-(2-((3-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
2,6-difluoro-N-(3-(5-(2-((3-((4-(3-methoxypropyl)piperazin-1-yl)methyl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
2-fluoro-N-(3-(5-(2-((3-((4-(3-methoxypropyl)piperazin-1-yl)methyl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
2-chloro-N-(3-(5-(2-((3-((4-(3-methoxypropyl)piperazin-1-yl)methyl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
N-(3-(5-(2-((3-((4-(3-methoxypropyl)piperazin-1-yl)methyl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
N-(3-(5-(2-((3-((4-(3-methoxypropyl)piperazin-1-yl)methyl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-N′-phenylurea,
N-(3-(5-(2-(1H-indazol-5-ylamino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-y1)phenyl)-2-phenylacetamide,
N-(3-(5-(2-(1H-indazol-5-ylamino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-y1)phenyl)benzamide,
2,6-difluoro-N-(3-(5-(2-(1H-indazol-5-ylamino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
2-chloro-6-fluoro-N-(3-(5-(2-(1H-indazol-5-ylamino)pyrimidin-4-yl)imidazo[2, l-b][1,3 ]thiazol-6-yl)phenyl)benzamide,
5-fluoro-N-(3-(5-(2-(1H-indazol-5-ylamino)pyrimidin-4-yl)imidazo [2,1 -b][1,3 ]thiazol-6-yl)phenyl)-2-methylbenzamide,
2-phenyl-N-(3-(5-(2-((2-(trifluoromethyl)-1H-benzimidazol-5-yl)amino)pyrimidin-4-yl)imidazo [2,1-b][1,3 ]thiazol-6-yl)phenyl)acetamide,
N-(3-(5-(2-((2-(trifluoromethyl)-1H-benzimidazol-5-yl)amino)pyrimidin-4-yl)imidazo [2,1-b][1,3 ]thiazol-6-yl)phenyl)benzamide,
2,6-difluoro-N-(3-(5-(2-((2-(trifluoromethyl)- 1H-benzimidazol-5 -yl)amino)pyrimidin-4-yl)imidazo [2,1-b][1,3 ]thiazol-6-yl)phenyl)benzamide,
2-chloro-6-fluoro-N-(3-(5-(2-((2-(trifluoromethyl)- 1H-benzimidazol-5 -yl)amino)pyrimidin-4-yl)imidazo [2,1-b][1,3 ]thiazol-6-yl)phenyl)benzamide,
5-fluoro-2-methyl-N-(3-(5-(2-((2-(trifluoromethyl)- 1H-benzimidazol-5-yl)amino)pyrimidin-4-yl)imidazo [2,1-b][1,3 ]thiazol-6-yl)phenyl)benzamide,
3-(5-(2-((3-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2, 1-b][1,3 ]thiazol-6-yl)-N′-(propionyloxy)benzenecarboximidamide,
N′-((3-methylbutanoyl)oxy)-3-(5-(2-((3-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo [2,1-b][1,3 ]thiazol-6-yl)benzenecarboximidamide,
3-(5-(2-((3-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2, 1-b][1,3 ]thiazol-6-yl)-N′-((phenylacetyl)oxy)benzenecarboximidamide,
3-methoxy-N-(3-(5-(2-((4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2, 1-b][1,3 ]thiazol-6-yl)phenyl)benzamide,
2-chloro-6-fluoro-N-(3-(5-(2-((2-pyridin-3-yl-1,3 -benzoxazol-5-yl)amino)pyrimidin-4-yl)imidazo[2, 1-b][1,3 ]thiazol-6-yl)phenyl)benzamide,
N-(3-(5-(2-((2-methyl- 1,3 -benzothiazol-5-yl)amino)pyrimidin-4-yl)imidazo [2,1-b][1,3 ]thiazol-6-yl)phenyl)-2-phenylacetamide,
N-(3-(5-(2-((2-methyl- 1,3 -benzothiazol-5-yl)amino)pyrimidin-4-yl)imidazo [2,1-b][1,3 ]thiazol-6-yl)phenyl)benzamide,
2,6-difluoro-N-(3-(5-(2-((2-methyl- 1,3 -benzothiazol-5-yl)amino)pyrimidin-4-yl)imidazo [2,1-b][1,3 ]thiazol-6-yl)phenyl)benzamide,
5-fluoro-2-methyl-N-(3-(5-(2-((2-methyl- 1,3 -benzothiazol-5-yl)amino)pyrimidin-4-yl)imidazo [2,1-b][1,3 ]thiazol-6-yl)phenyl)benzamide,
N-(3-(5-(2-((2-oxo-2,3-dihydro-1H-indo1-5-yl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
2-chloro-6-fluoro-N-(3-(5-(2-((2-oxo-2,3-dihydro-1H-indo1-5-yl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
N-(3-(5-(2-((3-(3-oxomorpholin-4-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
N-(3-(5-(2-((3-(3-oxomorpholin-4-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
2,6-difluoro-N-(3-(5-(2-((3-(3-oxomorpholin-4-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
2-chloro-6-fluoro-N-(3-(5-(2-((3-(3-oxomorpholin-4-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
2,6-dichloro-N-(3-(5-(2-((3-(3-oxomorpholin-4-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
5-fluoro-2-methyl-N-(3-(5-(2-((3-(3-oxomorpholin-4-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
2-fluoro-N-(3-(5-(2-((3-(3-oxomorpholin-4-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
N-(3-(5-(2-((4-(3-oxomorpholin-4-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
2,6-difluoro-N-(3-(5-(2-((4-(3-oxomorpholin-4-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
2-chloro-6-fluoro-N-(3-(5-(2-((4-(3-oxomorpholin-4-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
2,6-dichloro-N-(3-(5-(2-((4-(3-oxomorpholin-4-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
5-fluoro-2-methyl-N-(3-(5-(2-((4-(3-oxomorpholin-4-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
2-fluoro-N-(3-(5-(2-((4-(3-oxomorpholin-4-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
N-(3-(5-(2-((3-fluoro-5-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
2,6-difluoro-N-(3-(5-(2-((3-fluoro-5-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
N-(3-(5-(2-((3-fluoro-5-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-N′-phenylurea,
2-chloro-N-(3-(5-(2-((3-fluoro-5-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
N-(3-(5-(2-((3-fluoro-4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
2,6-difluoro-N-(3-(5-(2-((3-fluoro-4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
2-chloro-N-(3-(5-(2-((3-fluoro-4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
N-(3-(5-(2-((3-fluoro-4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-N′-phenylurea,
N-(3-(5-(2-((3-fluoro-5-(2-oxopyrrolidin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
2,6-difluoro-N-(3-(5-(2-((3-fluoro-5-(2-oxopyrrolidin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
2-chloro-N-(3-(5-(2-((3-fluoro-5-(2-oxopyrrolidin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
N-(3-(5-(2-((4-fluoro-3-(2-oxopyrrolidin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
2,6-difluoro-N-(3-(5-(2-((4-fluoro-3-(2-oxopyrrolidin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
2-chloro-N-(3-(5-(2-((4-fluoro-3-(2-oxopyrrolidin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
N-(3-(5-(2-((6-morpholin-4-ylpyridin-3-yl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-2-phenylacetamide,
2,6-difluoro-N-(3-(5-(2-((6-morpholin-4-ylpyridin-3-yl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
2-chloro-N-(3-(5-(2-((6-morpholin-4-ylpyridin-3-yl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)benzamide,
N-(3-(5-(2-((6-morpholin-4-ylpyridin-3-yl)amino)pyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)-N′-phenylurea,
4-(6-(3-(benzylamino)phenyl)imidazo[2,1-b][1,3]thiazol-5-yl)-N-(4-morpholin-4-ylphenyl)pyrimidin-2-amine,
N-(4-morpholin-4-ylphenyl)-4-(6-(3-((2-phenylethyl)amino)phenyl)imidazo[2,1-b][1,3]thiazol-5-yl)pyrimidin-2-amine,
N-(4-(4-isopropylpiperazin-1-yl)phenyl)-4-(6-(3-((5-phenyl-1,3,4-oxadiazol-2-yl)amino)phenyl)imidazo[2,1-b][1,3]thiazol-5-yl)pyrimidin-2-amine,
N-(4-morpholin-4-ylphenyl)-4-(6-(3-((pyridin-2-ylmethyl)amino)phenyl)imidazo[2,1-b][1,3]thiazol-5-yl)pyrimidin-2-amine,
4-(6-(3-((2,6-difluorobenzyl)amino)phenyl)imidazo[2,1-b][1,3]thiazol-5-yl)-N-(4-morpholin-4-ylphenyl)pyrimidin-2-amine, and
4-(6-(3-((2-methoxybenzyl)amino)phenyl)imidazo[2,1-b][1,3]thiazol-5-yl)-N-(4-morpholin-4-ylphenyl)pyrimidin-2-amine.
12. A composition comprising an excipient and a therapeutically effective amount of a compound of claim 1 .