Treatments for neurological disorders
View Patent ↗Disclosed are methods of improving impaired proprioception, treating brachial plexus injuries, regenerating large and small nerve fibers, treating dorsal root nerve injuries, and improving sensory neural responses in a subject by administration of a neublastin polypeptide.
1. A method of regenerating sensory nerve fibers, the method comprising administering to a human subject that has suffered an impairment or loss of sensory function and damage to or loss of sensory nerve fibers, an amount of a polypeptide effective to regenerate the sensory nerve fibers, the method resulting in the regeneration of the sensory nerve fibers and a persistent restoration of sensory function in the subject,
the polypeptide consisting of amino acids 15-113 of SEQ ID NO:1, amino acids 15-113 of SEQ ID NO:2, amino acids 15-113 of SEQ ID NO:3, amino acids 15-113 of SEQ ID NO: 4, amino acids 15-113 of SEQ ID NO:8, or amino acids 15-113 of SEQ ID NO: 9,
wherein the polypeptide, when dimerized, binds to a complex containing GFRα3 and RET, and
wherein the polypeptide is administered to the subject within one month following the damage to or loss of nerve fibers.
2. The method of claim 1 , wherein the nerve fibers are large nerve fibers.
3. The method of claim 1 , wherein the nerve fibers are small nerve fibers.
4. The method of claim 1 , wherein the subject has suffered damage to, or loss of, dorsal root nerve fibers.
5. The method of claim 1 , wherein the subject has suffered damage to or loss of nerve fibers distal to the dorsal root ganglia.
6. The method of claim 1 , wherein the nerve fibers are nerve fibers of the skin and the administration of the polypeptide results in skin reinnervation.
7. The method of claim 1 , wherein the polypeptide is administered to the subject within 48 hours following the damage to or loss of nerve fibers.
8. The method of claim 1 , wherein the polypeptide is administered to the subject within seven days following the damage to or loss of nerve fibers.
9. The method of claim 1 wherein the polypeptide is administered to the subject in two or more doses following the damage to or loss of nerve fibers.
10. The method of claim 1 , wherein administration of the polypeptide to the subject is terminated within six months following the damage to or loss of nerve fibers.
11. . The method of claim 1 , wherein administration of the polypeptide to the subject is terminated within one month following the damage to or loss of nerve fibers.
12. The method of claim 1 wherein administration of the polypeptide to the subject is terminated within two weeks following the damage to or loss of nerve fibers.
13. The method of claim 1 , wherein the damage to or loss of nerve fibers is a result of a nerve crush injury.
14. The method of claim 1 , wherein the polypeptide is administered to the subject via systemic administration.
15. The method of claim 1 , wherein the polypeptide is administered to the subject via subcutaneous administration.
16. The Method of claim 1 , wherein the polypeptide is administered to the subject via intravenous administration.
17. The method of claim 1 , wherein the polypeptide is administered locally to damaged neural tissue.
18. The method of claim 1 , wherein the polypeptide consists of amino acids 15-113 of SEQ ID NO:2, amino acids 15-113 of SEQ ID NO:3, amino acids 15-113 of SEQ ID NO:4, amino acids 15-113 of SEQ ID NO: 8 or amino acids 15-113 of SEQ ID NO: 9.
19. The method of claim 1 , wherein the polypeptide consists of amino acids 15-113 of SEQ ID NO:1.