PHARMACEUTICALS CONTAINING FLUOROQUINOLONES
The invention relates to pharmaceutical formulations in liquid form, containing fluoroquinolones and antioxidative sulphur compounds. The formulations are particularly suitable for parenteral uses and are distinguished, inter alia, by good tolerance.
1 . A pharmaceutical formulation, in liquid form, containing:
a fluoroquinolone
an antioxidative sulphur compound.
2 . The pharmaceutical formulation according to claim 1 , wherein the antioxidative sulphur compound is selected from the group consisting of a sulphite, a bisulphite, a thiosulphate, and an organic sulphur compound.
3 . The pharmaceutical formulation according to claim 1 , wherein the sulphite is sodium disulphite.
4 . The pharmaceutical formulation according to claim 1 , wherein the fluoroquinolone is selected from the group consisting of ciprofloxacin, enrofloxacin, pradofloxacin and marbofloxacin.
5 . The pharmaceutical formulation according to claim 4 , wherein the fluoroquinolone is pradofloxacin.
6 . The pharmaceutical formulation according to claim 4 , wherein the fluoroquinolone is enrofloxacin.
7 . The pharmaceutical formulation according to claim 4 , wherein the fluoroquinolone is marbofloxacin.
8 - 10 . (canceled)
11 . The pharmaceutical formulation according to claim 1 , further comprising pharmaceutical auxiliaries and/or additives.
12 . The pharmaceutical formulation according to claim 2 , wherein the sulphite is selected from the group consisting of sodium sulphite and potassium sulphite.
13 . The pharmaceutical formulation according to claim 2 , wherein the bisulphite is selected from the group consisting of sodium metabisulphite, potassium metabisulphite, potassium pyrosulphite, sodium pyrosulphite, acetosodium metabisulphite, and acetosodium bisulphite
14 . The pharmaceutical formulation according to claim 2 , wherein the thiosulphate is selected from the group consisting of potassium thiosulphate and sodium thiosulphate.
15 . The pharmaceutical formulation according to claim 2 , wherein the organic sulphur compound is selected from the group consisting of sodium formaldehyde sulphoxylate, thiourea, thiosorbitol, cysteine hydrochloride, cystine, cysteine, acetylcysteine, glutathione, cysteamine, methionine, thioglycerol, thioglycolic acid, and thiolactic acid.
16 . The pharmaceutical formulation of claim 1 , wherein the formulation is administered to an animal by injection.