Isotopically modified compounds and their use as food supplements
A nutrient composition comprises an essential nutrient in which at least one exchangeable H atom is 2 H and/or at least one C atom is 13 C. The nutrient is thus protected from, inter alia, reactive oxygen species.
1. A method for reducing lipid oxidation, comprising:
providing a patient a foodstuff containing an isotopically modified component at a level above the naturally-occurring abundance level of said isotopically modified component in said foodstuff;
wherein the isotopically modified component is a fatty acid or fat, that is isotopically modified at one or more bis-allylic positions;
wherein the isotopically modified component is at least 0.1% of the patient's diet;
wherein the isotopically modified component is regularly administered to the patient;
wherein the isotopically modified component or metabolite thereof is incorporated into the patient's body following administration;
wherein the isotopically modified component or metabolite thereof reduces the extent of lipid oxidation in the patient.
2. The method of claim 1 , wherein the lipid oxidation is mediated by free radicals, reactive oxygen species, reactive nitrogen species, or radiation in the subject.
3. The method of claim 1 , wherein the isotopically modified component or metabolite thereof is a fatty acid that is an essential food component.
4. The method of claim 3 , wherein the isotopically modified component is in a fatty acid that is not degraded by enzymes of the P450 pathway.
5. The method of claim 1 , wherein the fatty acid or fat is isotopically modified at one or ere bis-allylic position.
6. The method of claim 5 , wherein the fatty acid is 11-D-linoleic acid or 11,11-D 2 -linoleic acid.
7. The method of claim 6 , wherein the fatty acid is 11,11-D 2 -linoleic acid.
8. The method of claim 6 , wherein the fatty acid is administered with non-isotopically modified essential food components.
9. The method of claim 8 , wherein the ratio of isotopically modified fatty acid administered to non-isotopically modified fatty acid administered is greater than 1:1.
10. The method of claim 1 , wherein the isotopic modification comprises at least one 13 C atom or at least one deuterium atom at the one or more a bis-allylic positions, wherein the at least one 13 C atom or the at least one deuterium atom are present at a level significantly above the naturally-occurring abundance level of said isotope in said fatty acid.
11. The method of claim 10 , wherein the fatty acid is 11-D-linoleic acid or 11,11-D 2 -linoleic acid.
12. The method of claim 11 , wherein the fatty acid is 11,11-D 2 -linoleic acid.
13. The method of claim 10 , wherein the fatty acid is a polyunsaturated substance.
14. The method of claim 1 , wherein the fatty acid is 11-D-linoleic acid or 11,11-D 2 -linoleic acid.
15. The method of claim 14 , wherein the fatty acid is 11,11-D 2 -linoleic acid.
16. The method of claim 2 , wherein the lipid oxidation is mediated by free radicals.
17. The method of claim 1 , wherein the fatty acid is a carboxylic acid.