IP Library Granted Patent US 8,386,050
Granted Patent B2
US 8,386,050 · App. 12/285,886 · Granted Feb 26, 2013

Calibration systems and methods for neural interface devices

Inventors: John P. Donoghue (Providence, RI); J. Christopher Flaherty (Topsfield, MA); Mijail D. Serruya (Providence, RI); Abraham H. Caplan (Cambridge, MA); Maryam Saleh (Chicago, IL); Kirk F. Korver (Salt Lake City, UT); Almut Branner (Salt Lake City, UT)
Assignee: BrainGate Co., LLC
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Quick Facts
Patent No.
US 8,386,050
App. No.
12/285,886
Granted
Feb 26, 2013
Kind
B2
Abstract

A system and method for a neural interface system with integral calibration elements may include a sensor including a plurality of electrodes to detect multicellular signals, an interface to process the signals from the sensor into a suitable control signal for a controllable device, such as a computer or prosthetic limb, and an integrated calibration routine to efficiently create calibration output parameters used to generate the control signal. A graphical user interface may be used to make various portions of the calibration and signal processing configuration more efficient and effective.

Claims (38)

1. A method of calibrating a neural interface system, comprising:

detecting a set of multicellular signals emanating from a central nervous system of a patient using a sensor comprising a plurality of electrodes for chronic detection of the set of multicellular signals, while the patient imagines multiple movements;

receiving the set of multicellular signals from the sensor on an interface and processing the set of multicellular signals to generate a processed signal, wherein the processing includes excluding a multicellular signal from the set of multicellular signals, and wherein the processed signal is generated using one or more calibration output parameters;

transmitting the processed signal from the interface to a controlled device;

receiving the processed signal on the controlled device, and

entering into a lockout condition wherein the patient is prevented from controlling the controlled device prior to successfully completing the calibrating of the neural interface system and wherein a repeat calibration is required before the processed signals are transmitted to the controlled device.

2. The method of claim 1 wherein the patient imagines the movement of a part of the body.

3. The method of claim 1 further comprising comparing the multiple imagined movements to select the calibration output parameters.

4. The method of claim 1 further comprising categorizing the set of multicellular signals into three or more classifications for further processing into the processed signal for transmission to the controlled device.

5. The method of claim 1 wherein the detecting the set of multicellular signals is performed by a sensor having a two dimensional array of multiple protruding electrodes.

6. A method of calibrating a neural interface system, comprising:

detecting a set of multicellular signals emanating from a central nervous system of a patient using a sensor comprising a plurality of electrodes for chronic detection of the set of multicellular signals, while the patient thinks of an imagined movement, imagined state, or imagined event;

receiving the set of multicellular signals from the sensor on an interface and processing the set of multicellular signals to generate a processed signal, wherein the processing includes excluding a multicellular signal from the set of multicellular signals, and wherein the processed signal is generated using one or more calibration output parameters;

transmitting the processed signal from the interface to a controlled device;

receiving the processed signal on the controlled device, and

entering into a lockout condition wherein the patient is prevented from controlling the controlled device prior to successfully completing the calibrating of the neural interface system and wherein a repeat calibration is required before the processed signals are transmitted to the controlled device.

7. The method of claim 6 wherein the patient imagines an emotion.

8. The method of claim 6 wherein the patient imagines a thought of being hot or cold.

9. A method of calibrating a neural interface system, comprising:

using audio cues, visual cues, olfactory cues and tactile cues to trigger a patient's imagination;

detecting a set of multicellular signals emanating from a central nervous system of a patient using a sensor comprising a plurality of electrodes for chronic detection of the set of multicellular signals;

receiving the set of multicellular signals from the sensor on an interface and processing the set of multicellular signals to generate a processed signal, wherein the processing includes excluding a multicellular signal from the set of multicellular signals, and wherein the processed signal is generated using one or more calibration output parameters;

transmitting the processed signal from the interface to a controlled device;

receiving the processed signal on the controlled device, and

entering into a lockout condition wherein the patient is prevented from controlling the controlled device prior to successfully completing the calibrating of the neural interface system and wherein a repeat calibration is required before the processed signals are transmitted to the controlled device.

10. The method of claim 9 wherein calibrating comprises:

setting a preliminary set of calibration output parameters;

using the preliminary set of calibration output parameters to generate the processed signal;

measuring the performance of the controlled device; and

modifying the calibration output parameters.

11. The method of claim 9 further comprising using one or more calibration input parameters to determine the calibration output parameters.

12. The method of claim 9 further comprising categorizing the set of multicellular signals into three or more classifications for further processing into the processed signal for transmission to the controlled device.

13. The method of claim 9 wherein the detecting the set of multicellular signals is performed by a sensor having a two dimensional array of multiple protruding electrodes.

14. The method of claim 9 wherein the calibration output parameters are set within preset limits.

15. The method of claim 9 further comprising using one or more calibration input parameters to determine the calibration output parameters.

16. The method of claim 9 further comprising categorizing the set of multicellular signals into three or more classifications for further processing into the processed signal for transmission to the controlled device.

17. The method of claim 9 further comprising storing the calibration output parameters in memory.

18. The method of claim 9 further comprising displaying signals received from the sensor on a display monitor.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 5, 2023
From: BRAINGATE, CO., LLC
To: BRAINGATE, INC.
Reel/Frame 065768/0351 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 11, 2009
From: DONOGHUE, JOHN P.; FLAHERTY, CHRISTOPHER J.; SERRUYA, MIJAIL D.; CAPLAN, ABRAHAM H.; SALEH, MARYAM; KORVER, KIRK F.; BRANNER, ALMUT
To: CYBERKINETICS, INC.
Reel/Frame 022663/0208 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 11, 2009
From: CYBERKINETICS, INC.
To: BRAINGATE CO., LLC
Reel/Frame 022663/0346 →
Continuity (3)
Continuation 10978818 · Nov 2, 2004
Provisional Application 60519047 · Nov 9, 2003
Related Publication 20100063411A1 · Mar 11, 2010