Synthetic arginine substituted peptides and their use
View Patent ↗The present invention relates to new arginine substituted peptides designed based on the sequence of human lactoferrin and to use thereof, in particular for treatment and/or prevention of infections, inflammations, tumours, pain, wounds and/or scars.
1. A purified peptide comprising SEQ ID NO: 12 (Phe-Gln-Trp-Xaa-Arg-Xaa-Met-Arg-Lys-Val-Arg-Gly-Ser-Arg-Arg-Arg-Arg-Gly), wherein the amino acid Xaa at position 4 of SEQ ID NO: 12 is Gln or Lys, and the amino acid Xaa at position 6 of SEQ ID NO: 12 is Asn or Ala, and wherein the peptide is SEQ ID NO: 5, 6, 7, 8, 9, or 10.
2. A peptide according to claim 1 , wherein the free COOH at the carboxy terminal end has been transformed into CONH 2 .
3. A peptide according to claim 1 , wherein the free NH 2 group at the amino terminal end has been transformed into the amide CH 3 CONH.
4. A peptide according claim 1 , wherein the amino acid Cys, if present, has been replaced by an acetamidomethyl-cysteine.
5. A pharmaceutical composition comprising a peptide according to claim 1 .
6. A pharmaceutical composition according to claim 5 formulated for systemic, parenteral, local or topical administration.
7. A method for treatment of wounds wherein an effective amount of a peptide according to claim 1 is administered to a patient.
8. A method according to claim 7 , wherein the substance is systemically, parenterally, locally or topically administered.