HIV inhibiting 5-amido substituted pyrimidines

1. A compound of formula

or a stereochemically isomeric form thereof, or a pharmaceutically acceptable addition salt thereof, or a pharmaceutically acceptable hydrate or solvate thereof, or a N-oxide thereof, wherein

R 5 is C 3-7 cycloalkyl; C 1-6 alkyloxy; aryl; Het; C 1-6 alkyl substituted with a radical selected from hydroxy, C 1-6 alkyloxy, cyano, amino, mono- and di-C 1-6 alkylamino, C 1-6 alkylcarbonylamino, aryl, Het, dioxolanyl optionally substituted with one or two C 1-6 alkyl radicals, tetrahydrofuranyl, pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, piperazinyl optionally substituted with C 1-6 alkyl or C 1-6 alkylcarbonyl, C 1-6 alkyloxycarbonyl, arylC 1-6 alkyloxycarbonyl, and C 3-7 cycloalkyl; or R 5 is C 1-6 alkyl substituted with two C 1-6 alkyloxy radicals;

R 6 is hydrogen or C 1-6 alkyl; or

R 5 and R 6 taken together with the nitrogen atom to which they are attached form pyrrolidinyl; piperidinyl; morpholinyl; piperazinyl; piperazinyl optionally substituted with C 1-6 alkyl or C 1-6 alkylcarbonyl;

each Het independently is pyridyl, thienyl, furanyl, oxazolyl, thiazolyl, thiadiazolyl, oxadiazolyl, isoxazolyl, isothiazolyl, imidazolyl, triazolyl, tetrazolyl, pyrazolyl, quinolinyl, benzothienyl, benzofuranyl, benzoxazolyl, benzothiazolyl; which each may optionally be substituted with one or two substituents each independently selected from C 1-6 alkyl, halo, hydroxy, cyano, C 1-6 alkyloxy, C 2-12 alkenyl substituted with halo, hydroxy or with cyano; and

each aryl independently is phenyl or phenyl substituted with one, two, three, four or five substituents each independently selected from halo, hydroxy, mercapto, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, hydroxyC 1-6 alkyl, aminoC 1-6 alkyl, mono and di(C 1-6 alkyl)-aminoC 1-6 alkyl, C 1-6 alkyl-carbonyl, C 3-7 cycloalkyl, C 1-6 alkyloxy, phenylC 1-6 alkyloxy, C 1-6 alkyloxycarbonyl, aminosulfonyl, C 1-6 alkylthio, cyano, nitro, polyhaloC 1-6 alkyl, polyhaloC 1-6 alkyloxy, aminocarbonyl, phenyl, Het, and —Y-Het.

2. A compound according to claim 1 wherein R 5 is C 3-7 cycloalkyl; C 1-6 alkyloxy; aryl; Het; C 1-6 alkyl substituted with a radical selected from hydroxy, C 1-6 alkyloxy, cyano, di-C 1-6 alkylamino, C 1-6 alkylcarbonylamino, aryl, Het, dioxolanyl substituted with two C 1-6 alkyl radicals, tetrahydrofuranyl, pyrrolidinyl, C 1-6 alkyloxycarbonyl, and C 3-7 cycloalkyl;

R 6 is hydrogen or C 1-6 alkyl; or

R 5 and R 6 taken together with the nitrogen atom to which they are substituted form morpholinyl or piperazinyl substituted with C 1-6 alkyl.

3. A compound according to claim 1 wherein R 5 is C 3-7 cycloalkyl; C 1-6 alkyloxy; or C 1-6 alkyl substituted with a radical selected from hydroxy, C 1-6 alkyloxy, cyano, C 1-6 alkylcarbonylamino, aryl, Het, and C 1-6 alkyloxycarbonyl; and

R 6 is hydrogen.

4. A compound according to claim 1 wherein each Het independently is pyridyl, thienyl, thiazolyl, or furanyl, each of which may be optionally substituted with a radical selected from C 1-6 alkyl.

5. A compound according to claim 1 wherein each aryl independently is phenyl optionally substituted with C 1-6 alkyl, amino, mono- or diC 1-6 alkyl-amino, C 1-6 alkyloxy, aminosulfonyl, or Het.

6. A compound according to claim 1 wherein each aryl independently is phenyl optionally substituted with C 1-6 alkyl, amino, mono- or C 1-6 alkyloxy, aminosulfonyl, or thiadiazolyl.

7. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and as active ingredient a therapeutically effective amount of a compound as claimed in claim 1 .