Eccentrically-rotating reactor
View Patent ↗The invention relates to a reactor driven in an oscillatory-rotary manner about its fixed, preferably vertical, axis, for preferably biotechnological and pharmaceutical applications. By means of its process-intensifying properties for mixing, suspension, gaseous material transport, heat transfer, irradiation and particle retention, the applicability on the industrial scale is ensured. The reactor which succeeds without a shaft seal permits particularly robust production with respect to sterile technique with avoidance of cleaning and cleaning validation required when the reactor is constructed as a single-use reactor.
1. A reactor comprising a reactor vessel and a drive unit, wherein contents of the reactor vessel are rotated in periodically opposite directions about a fixed vertical axis of the reactor vessel by the drive unit, wherein a mechanical power input from the drive unit into the reactor vessel contents is enabled by a member of the group consisting of a shell form of the reactor vessel having a polygonal cross section at least in a region of the surface of the reactor contents and mixing elements fixed within the reactor vessel, the reactor being a sparged reactor, wherein the reactor vessel has a polygonal cross section at least in a region of a liquid surface of reactor contents taken up by the reactor vessel, which reactor contents are charged with gas bubbles via the surface or porous membranes and, for the purpose of foam destruction, are rotated in opposite directions in a periodic fashion such that foam on a surface of the reactor contents is transported into an interior of the reactor contents.