GEMCITABINE COMBINATION THERAPY
The present invention provides compositions and methods for the treatment of cell proliferative disorders using at least one DAC inhibitor and gemcitabine.
1 . A method comprising steps of:
administering to a subject suffering from or susceptible to a cell proliferative disorder, combination therapy of a DAC inhibitor and gemcitabine.
2 . The method of claim 1 wherein the cell proliferative disorder involves a tumor.
3 . The method of claim 2 , wherein the tumor is a Ras-expressing tumor.
4 . The method of claim 2 , wherein the tumor is a pancreatic tumor.
5 . The method of claim 1 , wherein the DAC inhibitor is romidepsin.
6 . The method of claim 1 further comprising administering electrolyte supplementation.
7 . The method of claim 1 , wherein the cell proliferative disorder is cutaneous T-cell lymphoma.
8 . The method of claim 1 , wherein the cell proliferative disorder is peripheral T-cell lymphoma.
9 . The method of claim 1 , wherein the cell proliferative disorder is a hematological malignancy.