Biocompatible Hydrogels
A biocompatible macromer composition is provided which includes a first polymer possessing a first nucleoside, and a second polymer possessing a second nucleoside that is complementary to the first nucleoside and capable of undergoing base pairing with the first nucleoside. The biocompatible macromer composition can be used as an adhesive or sealant in human and/or animal medical applications.
1 . A biocompatible macromer composition comprising:
a first polymer comprising a first nucleoside; and
a second polymer comprising a second nucleoside,
wherein the first nucleoside and the second nucleoside undergo base pairing, and the composition acts as an adhesive, sealant, or gene delivery device.
2 . A biocompatible macromer composition as in claim 1 , wherein the first polymer comprises an oligonucleotide.
3 . A biocompatible macromer composition as in claim 1 , wherein the second polymer comprises an oligonucleotide.
4 . A biocompatible macromer composition as in claim 1 , wherein the first polymer comprises a polynucleotide.
5 . A biocompatible macromer composition as in claim 1 , wherein the second polymer comprises a polynucleotide.
6 . A biocompatible macromer composition as in claim 1 , wherein the molecular weight of the first polymer and optionally the second polymer is from about 1×10 3 g/mol to about 1×10 6 g/mol.
7 . A biocompatible macromer composition as in claim 1 , wherein the molecular weight of the first polymer and optionally the second polymer is from about 1×10 4 g/mol to about 1×10 5 g/mol.
8 . A biocompatible macromer composition as in claim 1 , wherein the first polymer further comprises a polymer selected from the group consisting of polyalkylene oxides, polysaccharides, esters, aliphatic esters, orthoesters, phosphoesters, carbonates, urethanes, ethers, amides, phenolics, and combinations thereof.
9 . A biocompatible macromer composition as in claim 1 , wherein the second polymer further comprises a polymer selected from the group consisting of polyalkylene oxides, polysaccharides, esters, aliphatic esters, orthoesters, phosphoesters, carbonates, urethanes, ethers, amides, phenolics, and combinations thereof.
10 . A biocompatible macromer composition as in claim 1 , wherein the first polymer further comprises a first functional group selected from the group consisting of acids, amines, sulfones, isocyanates, hydroxyl groups, vinyl groups, esters, and combinations thereof, and the second polymer further comprises a second functional group that crosslinks with the first functional group.
11 . A biocompatible macromer composition as in claim 1 , wherein the first polymer and optionally the second polymer further comprises bioabsorbable groups selected from the group consisting of α-hydroxy acids, esters, lactones, carbonates, ester ethers, diacids, and combinations thereof.
12 . A biocompatible macromer composition as in claim 1 , wherein the first polymer and optionally the second polymer further comprises bioabsorbable groups selected from the group consisting of lactic acid, glycolic acid, lactide, glycolide, ε-caprolactone, trimethylene carbonate, 1,4-dioxane-2-one, 1,3-dioxane-2-one, succinnic acid, adipic acid, sebacic acid, malonic acid, glutaric acid, and combinations thereof.
13 . A biocompatible macromer composition as in claim 1 , wherein the first polymer is present in an amount from about 10% to about 90% by weight of the synthetic macromer composition.
14 . A biocompatible macromer composition as in claim 1 , wherein the second polymer is present in an amount from about 90% to about 10% by weight of the synthetic macromer composition.
15 . A biocompatible macromer composition as in claim 1 , wherein the first polymer and optionally the second polymer is combined with enzymatically degradable components.
16 . An adhesive for wound closure comprising the biocompatible macromer composition of claim 1 .
17 . A sealant for use in a medical application comprising the biocompatible macromer composition of claim 1 .
18 . A method for closing a wound comprising:
applying the biocompatible macromer composition of claim 1 to said wound; and
allowing the biocompatible macromer composition to set thereby closing said wound.
19 . The method of claim 18 , wherein the wound is a surgical incision.
20 . A method for filling a void in animal tissue comprising:
applying the biocompatible macromer composition of claim 1 to said void; and
allowing the biocompatible macromer composition to set thereby filling said void.
21 . A method for adhering a medical device to a surface of animal tissue comprising the steps of:
applying the biocompatible macromer composition of claim 1 to said device, said surface or both;
bringing the device, biocompatible macromer composition and surface into contact with each other; and
allowing the biocompatible macromer composition to set thereby adhering the device and surface to each other.
22 . The method of claim 21 wherein said medical device is an implant.
23 . A method for delivering a gene comprising:
administering the biocompatible macromer composition of claim 1 to an animal;
allowing the biocompatible macromer composition to set thereby forming a gel; and
allowing the biocompatible macromer composition to degrade in vivo, wherein degradation of the biocompatible macromer composition delivers a gene to the animal.