Composition

1 . A composition comprising:

i) at least one strain of a Lactobacillus sp and/or a metabolite thereof; and

ii) a cannabinoid receptor agonist and/or a opioid receptor antagonist.

2 . A composition according to claim 1 wherein the composition is a food composition and optionally further comprises a food ingredient.

3 . A composition according to claim 1 wherein the composition is a pharmaceutical composition and optionally further comprises a pharmaceutically acceptable carrier, diluent or excipient.

4 . A composition according to claim 1 wherein the at least one strain of a Lactobacillus sp and/or a metabolite thereof is a Lactobacillus acidophilus strain and/or a metabolite thereof, a Lactobacillus salivarius strain and/or a metabolite thereof, and/or a Lactobacillus casei strain and/or a metabolite thereof.

5 . A composition according to claim 1 wherein the at least one strain of a Lactobacillus sp and/or a metabolite thereof is a Lactobacillus acidophilus strain and/or a metabolite thereof.

6 . A composition according to claim 1 wherein said Lactobacillus acidophilus strain and/or a metabolite thereof is Lactobacillus acidophilus NCFM and/or a metabolite thereof.

7 . A composition according to claim 1 wherein the at least one strain of a Lactobacillus salivarius and/or a metabolite thereof is Lactobacillus salivarius LS 33 and/or a metabolite thereof.

8 . A composition according to claim 1 wherein the at least one strain of a Lactobacillus sp is present in the amount of 10 6 to 10 14 CFU, preferably 10 8 to 10 12 CFU.

9 . A method of treating and/or ameliorating any one or more of the group selected from: pain, inflammation, neoplasism and diarrhea comprising administering an effective amount of a composition according to claim 1 .

10 . A composition according to claim 1 for use as a medicament.

11 . Use of a composition according to claim 1 as one or more of the following selected from the group consisting of: an analgesic, an anti-inflammatory, an anti-diarrheic and an anti-neoplastic.

12 . Use according to claim 11 wherein said use is as an analgesic.

13 . Use of a composition according to claim 1 in the manufacture of a medicament for treating and/or ameliorating the perception of pain.

14 . Use according to claim 13 when said pain is pain associated with irritable bowel syndrome and/or irritable bowel disease.

15 . Use of a composition according to claim 1 in the manufacture of a medicament for treating and/or ameliorating diarrhea.

16 . Use of a composition according to claim 1 in the manufacture of a medicament for treating and/or ameliorating inflammation.

17 - 19 . (canceled)