Methods and compositions related to eosinophil regulation
Disclosed are compositions and methods for regulating eosinophils.
1. A method of inhibiting or reducing eosinophil development in a subject comprising reducing Eosinophil Granule Ontogeny mRNA levels in the subject, wherein reducing Eosinophil Granule Ontogeny mRNA levels comprises administering to the subject an inhibitor of Eosinophil Granule Ontogeny.
2. The method of claim 1 , wherein the inhibitor of Eosinophil Granule Ontogeny is a viral vector, wherein delivery of the vector to a cell inhibits eosinophil development.
3. The method of claim 2 , wherein the vector comprises a nucleic acid operably linked to an expression control sequence and wherein the nucleic acid inhibits eosinophil development.
4. The method of claim 1 , wherein the subject has asthma, a skin disease, atopic dermatitis, urticaria, drug reactions, reactions to insect stings, cutaneous T-cell lymphoma (CTCL), Eosinophilia Myalgia Syndrome, Toxic Oil Syndrome, eosinophilic esophagitis, or Hypereosinophilic Syndrome.
5. The method of claim 1 , wherein the inhibitor of Eosinophil Granule Ontogeny is a functional nucleic acid.
6. The method of claim 5 , wherein the functional nucleic acid is siRNA.
7. The method of claim 6 , wherein the siRNA targets EGO-A, EGO-B, or parts thereof.
8. The method of claim 6 , wherein the siRNA targets EGO-A, EGO-B, or parts of EGO-A and EGO-B.
9. The method of claim 6 , wherein the siRNA is SEQ ID NO: 16.