IP Library › Granted Patent US 8,426,568
Granted Patent B2
US 8,426,568 · App. 12/301,656 · Granted Apr 23, 2013

Rhamnose substituents of SL0101 and therapeutic uses thereof

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Quick Facts
Patent No.
US 8,426,568
App. No.
12/301,656
Granted
Apr 23, 2013
Kind
B2
Abstract

The present invention provides compositions and methods useful for preparing and using analogs, derivatives, and modifications of kaempferols that have anti-neoplastic activity. More specifically, the compounds are analogs, derivatives, and modifications of SLO1O1. The invention further provides compounds that are inhibitors of rsk activity. The invention further provides compounds that selectively inhibit excessive rsk activity in cancers. The present invention further provides methods for treating cancer using compounds of the invention.

Claims (7)

1. An isolated compound represented by the general structure of formula I:

wherein

each of R1, R2, and R3 are OAc.

2. An isolated compound represented by the general structure of formula I:

wherein

R2 and R3 are butyryl; and

R1 is OH.

Assignments (4)
SECURITY INTEREST Recorded Mar 9, 2022
From: LUNA LABS USA, LLC
To: M&T BANK
Reel/Frame 059211/0861 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 13, 2010
From: SMITH, JEFFREY A.; HECHT, SIDNEY M.; LANNIGAN-MACARA, DEBORAH A.; MALONEY, DAVID J.
To: UNIVERSITY OF VIRGINIA
Reel/Frame 023775/0275 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 13, 2010
From: UNIVERSITY OF VIRGINIA
To: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
Reel/Frame 023775/0357 →
CONFIRMATORY LICENSE Recorded Aug 13, 2009
From: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
To: US GOVERNMENT - SECRETARY FOR THE ARMY
Reel/Frame 023097/0196 →