Method of treating lung fibrosis using ST2 polypeptide
View Patent ↗Methods and compositions for treating fibrosis are disclosed.
1. A method of treating lung fibrosis in a subject, the method comprising administering to the subject a soluble ST2 polypeptide, or a fragment comprising amino acids 1-336 of SEQ ID NO: 2, in an amount effective to treat lung fibrosis.
2. The method of claim 1 , wherein the soluble ST2 polypeptide is an ST2 fusion protein.
3. The method of claim 2 , wherein the fusion protein is an ST2-Fc fusion protein.
4. The method of claim 1 , wherein the subject is a human.
5. The method of claim 1 , wherein the soluble ST2 polypeptide is administered intramuscularly.
6. The method of claim 1 , wherein the soluble ST2 polypeptide is administered intravenously.
7. The method of claim 1 , wherein the soluble ST2 polypeptide is administered at a unit dosage ranging from 2 to 30 mg.
8. The method of claim 1 , further comprising evaluating the subject for effectiveness of treatment.
9. A method of treating lung fibrosis in a subject, the method comprising:
identifying a subject in need of treatment for lung fibrosis, and
administering a soluble ST2 polypeptide to the subject.
10. The method of claim 9 , wherein the soluble ST2 polypeptide is an ST2-Fc fusion protein.
11. A method of treating lung fibrosis in a subject, the method comprising administering to the subject an ST2 fragment comprising an amino acid sequence that is amino acids 1-336 of SEQ ID NO: 2.