3-(1,3-benzodioxol-5-yl)-6-(4-cyclopropylpiperazin-1-yl)-pyridazine, its salts and solvates and its use as histamine H3 receptor antagonist
View Patent ↗3-(1,3-Benzodioxol-5-yl)-6-(4-cyclopropylpiperazin-1-yl)pyridazine and salts and solvates thereof, having histamine H3 antagonistic activity can be used in pharmaceutical compositions.
1. 3-(1,3-Benzodioxol-5-yl)-6-(4-cyclopropylpiperazin-1-yl)pyridazine or a pharmaceutically acceptable salt, or solvate thereof.
2. The compound of claim 1 , where the compound is 3-(1,3-benzodioxol-5-yl)-6-(4-cyclopropylpiperazin-1-yl)pyridazine or solvate thereof.
3. The compound of claim 1 , where the compound is a hydrochloride salt of 3-(1,3-benzodioxol-5-yl)-6-(4-cyclopropylpiperazin-1-yl)pyridazine or solvate thereof.
4. The compound of claim 3 , where the compound is a 3-(1,3-benzodioxol-5-yl)-6-(4-cyclopropylpiperazin-1-yl)pyridazine dihydrochloride or solvate thereof.
5. A hydrate of a compound, where the compound is 3-(1,3-benzodioxol-5-yl)-6-(4-cyclopropylpiperazin-1-yl)pyridazine or a pharmaceutically acceptable salt thereof.
6. The hydrate of claim 5 , where the compound is 3-(1,3-benzodioxol-5-yl)-6-(4-cyclopropylpiperazin-1-yl)pyridazine.
7. The hydrate of claim 5 , where the compound is 3-(1,3-benzodioxol-5-yl)-6-(4-cyclopropylpiperazin-1-yl)pyridazine dihydrochloride.
8. The hydrate of claim 6 , where the hydrate is a monohydrate.
9. The hydrate of claim 7 , where the hydrate is a monohydrate.
10. A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier or excipient.
11. A pharmaceutical composition comprising a compound of claim 5 and a pharmaceutically acceptable carrier or excipient.