IP Library Granted Patent US 8,227,749
Granted Patent B2
US 8,227,749 · App. 12/305,613 · Granted Jul 24, 2012

Pulsed flow ion mobility spectrometer

Assignee: Owlstone Limited
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Quick Facts
Patent No.
US 8,227,749
App. No.
12/305,613
Granted
Jul 24, 2012
Kind
B2
Abstract

An ion mobility spectrometer is described which makes use of a pulsed flow pump to draw gas through an ion filter in pulsed operation. A gas counterflow may also be provided, in some embodiments this may also be a pulsed counterflow.

Claims (30)

1. An ion mobility spectrometer comprising:

a) an ionizer;

b) an ion detector;

c) an ion filter defining at least one ion channel along which ions may pass from the ionizer to the ion detector;

d) a pump operable to draw gas through the ion filter in pulsed operation and;

e) means for generating a drive electric field having one or more electrodes to draw ions through the ion filter, wherein said means for generating also forms at least a portion of the ion filter adapted and configured for controlling electrodes arranged adjacent the ion channel such that a first drive electric field is generated along the length of the ion channel, and a second filter electric field is generated orthogonal to the first.

2. The spectrometer of claim 1 , wherein the pump is operable to draw gas from the ionizer toward the ion filter.

3. The spectrometer of claim 1 , wherein the pump is operable to draw gas from the ion filter toward the ion detector.

4. The spectrometer of claim 1 , wherein the pump is selected from the group comprising diaphragm pumps, speaker pumps, piezoelectric pumps, and peristaltic pumps.

5. The spectrometer of claim 1 , further comprising means for generating a first drive electric field to draw ions from the ionizer toward the ion filter.

6. The spectrometer of claim 5 , wherein the generating means comprises one or more electrodes arranged adjacent the ion filter.

7. The spectrometer of claim 5 , wherein the generating means comprises a deflector electrode located adjacent the ionizer to direct ions away from the ionizer.

8. The spectrometer of claim 7 , wherein the ion detector comprises a second electrode coupled to the deflector electrode to attract ions.

9. The spectrometer of claim 1 , wherein each of said electrodes is involved in generating a component of both the drive and filter electric fields.

10. The spectrometer of claim 1 , wherein the ion filter comprises a plurality of electrodes.

11. The spectrometer of claim 1 , wherein the filter defines multiple ion channels.

12. The spectrometer of claim 1 , wherein the ion filter comprises at least one pair of electrodes disposed along the ion channel, such that the electrodes may be used to generate an electric field orthogonal to the direction of ion flow along the channel.

13. The spectrometer of claim 1 , further comprising a drift gas source.

14. The spectrometer of claim 1 , further comprising a scrubber for cleaning the gas.

15. The spectrometer of claim 14 , wherein the scrubber comprises a filter for removing particulates from the gas.

16. The spectrometer of claim 14 , wherein the scrubber comprises a dehumidifier for controlling the moisture content of the gas.

17. The spectrometer of claim 1 , further comprising means for generating a gas counterflow.

18. The spectrometer of claim 17 , wherein the means for generating a counterflow is the pump operable to draw gas from the ionizer toward the ion filter in pulsed operation.

19. The spectrometer of claim 17 , wherein the means for generating a counterflow is a separate pump.

20. The spectrometer of claim 17 , wherein the counterflow is pulsed.

21. The spectrometer of claim 17 , wherein the flow and counterflow are asymmetric.

22. The spectrometer of claim 17 , wherein the overall volume of gas passed during the flow and counterflow are equal.

23. The spectrometer of claim 17 , wherein the means for generating a counterflow is operable to purge the spectrometer prior to a measurement cycle of the spectrometer.

24. The spectrometer of claim 1 , further comprising means for synchronizing the operation of the ion detector with the operation of the flow pump.

25. The spectrometer of claim 1 , further comprising means for combining a plurality of ion detection operations into a single measurement.

Assignments (5)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 30, 2016
From: OWLSTONE INC.
To: OWLSTONE MEDICAL LIMITED
Reel/Frame 038139/0701 →
RELEASE OF SECURITY INTEREST Recorded Mar 30, 2016
From: INGALLS & SNYDER LLC
To: OWLSTONE INC.
Reel/Frame 038140/0594 →
SECURITY AGREEMENT Recorded Apr 9, 2013
From: OWLSTONE INC.
To: INGALLS & SNYDER LLC, AS COLLATERAL AGENT
Reel/Frame 030175/0367 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 2, 2013
From: OWLSTONE LIMITED
To: OWLSTONE INC.
Reel/Frame 030129/0306 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 4, 2010
From: ALONSO, DAVID RUIZ
To: OWLSTONE LIMITED
Reel/Frame 024331/0289 →
Priority Claims (1)
GB 0612042.2 · Jun 19, 2006 · national
Continuity (1)
Related Publication 20110198490A1 · Aug 18, 2011