Microcapsules with improved shells
Disclosed are microcapsules and methods for preparing and using them, as well as methods for improving various properties of microcapsules like impermeability.
1. A microcapsule, comprising an agglomeration of primary microcapsules and a loading substance, each individual primary microcapsule having a primary shell, wherein the loading substance is encapsulated by the primary shell, wherein the agglomeration is encapsulated by an outer shell, wherein the primary and outer shell is a complex coacervate of gelatin and polyphosphate and wherein the primary shell, the outer shell, or both comprise an additional composition that is not part of the complex coacervate, said additional composition being selected from the group consisting of glucose, fructose, galactose, arabinose, ribose, ribulose, xylose, mannose, xylulose, sucrose, lactose, cellobiose, sorbose, trehalose, maltose, xylitol, sorbitol, isomalt, and glucosamine.
2. The microcapsule of claim 1 , further comprising a chelator, wherein the chelator comprises one or more of citric acid, phytic acid, malic acid, tartaric acid, oxalic acid, succinic acid, polyphosphoric acids, disodium ethylenediamine tetraacetic acid, or a mixture thereof.
3. The microcapsule of claim 1 , wherein the loading substance comprises a biologically active substance.
4. The microcapsule of claim 1 , wherein the loading substance comprises microbial oil, marine oil, algal oil, oil from a dinoflagellate, fungal oil, plant oil, oil from Crypthecodinium cohnii , oil from Thraustochytrium, Schizochytrium , or a mixture thereof.
5. The microcapsule of claim 1 , wherein the loading substance comprises fish oil.
6. The microcapsule of claim 1 , wherein the loading substance comprises an omega-3 fatty acid, an alkyl ester of an omega-3 fatty acid, a triglyceride ester of an omega-3 fatty acid, a phytosterol ester of an omega-3 fatty acid, and/or a mixture thereof.
7. The microcapsule of claim 1 , wherein the loading substance comprises docosahexaenoic acid and/or eicosapentaenoic acid, a C 1 -C 6 alkyl ester thereof, a triglyceride ester thereof, a phytosterol ester thereof, and/or a mixture thereof.
8. The microcapsule of claim 1 , wherein the loading substance is from 20% to 90% by weight of the microcapsule.
9. The microcapsule of claim 1 , wherein the loading substance is from 50% to 70% by weight of the microcapsule.
10. The microcapsule of claim 1 , wherein the primary shell has an average diameter of from 40 nm to 10 μm.
11. The microcapsule of claim 1 , wherein the primary shell has an average diameter of from 0.1 μm to 5 μm.
12. The microcapsule of claim 1 , wherein the outer shell has an average diameter of from 20 μm to 1,000 μm.
13. The microcapsule of claim 1 , wherein the outer shell has an average diameter of from 30 μm to 80 μm.
14. The microcapsule of claim 1 , wherein the composition further comprises an antioxidant and the antioxidant comprises coenzyme Q 10 , lutein, zeaxanthan, carotene, or a mixture thereof.
15. The microcapsule of claim 1 , wherein the gelatin comprises gelatin type A.
16. The microcapsule of claim 1 , wherein the gelatin comprises fish gelatin.
17. The microcapsule of claim 1 , wherein the gelatin comprises pork gelatin.