Methods of treating reproductive cancer

1. A method of treating a reproductive cancer comprising administering to a subject a pharmaceutical composition comprising an agent comprising a peptide sequence selected from the group consisting of:

i)

pLGlu-LHis-LTrp-LSer-LHis-DArg-LTrp-LTyr-

LPro- A ;

ii)

pLGlu-LHis-LTrp-LSer-LHis-DTrp-LTrp-LTyr-

LPro- A ;

iii)

pLGlu-LHis-LTrp-LSer-LTyr-DLys-LTrp-LGln-

LPro- A ;

iv)

pLGlu-LHis-LTrp-LSer-LTyr-DLys-LTrp-LLeu-

LPro- A ;

v)

pLGlu-LHis-LTrp-LSer-LTyr-DLys-LTrp-LTyr-

LPro- A ;

v-B)

pLGlu-LHis-LTrp-LSer-LTyr-DLys-LTrp-LArg-

LPro- A ;

vi)

pLGlu-LHis-LTrp-LSer-LTyr-DTrp-LTrp-LArg-

LPro- A ;

vii)

pLGlu-LHis-LTrp-LSer-LHis-DLys-LTrp-LTyr-

LPro- A ;

viii)

pLGlu-LHis-LTrp-LSer-LHis-DArg-LTrp-LTyr-

LPro. Y ;

ix)

pLGlu-LHis-LTrp-LSer-LHis-DArg-LLeu-LArg-

LPro- A ;

x)

pLGlu-LHis-LTrp-LSer-LHis-DTrp-LTrp-LArg-

LPro- A ;

xi)

pLGlu-LHis-LTrp-LSer-LHis-DTrp-LLeu-LArg-

LPro- A ;

xii)

pLGlu-LHis-LTrp-LSer-LHis-DTyr-LLeu-LArg-

LPro- A ;

xiii)

pLGlu-LHis-LTrp-LSer-LHis-DAla-LTrp-LTyr-

LPro- A ;

xiv)

pLGlu-LHis-LTrp-LSer-LHis-DSer-LTrp-LTyr-

LPro- A

wherein

R2 is any D-amino acid except DTrp;

Y selected from the group consisting of NHEt, NH 2 , DAla-NH 2 , and Z; and

A is selected from the group consisting of:

Z;

azaL-Gly;

azaL-Gly-Z;

D-Ala-Z;

L-Glu-Z;

D-Ala-L-Glu-Z;

D-Ala-D-Ala-Z;

βAla-Z;

L-Pro;

L-Pro-Z;

D-Ala-L-Gly-Z; and

L-Gly-Z;

wherein Z is selected from the group consisting of NH 2 , N-ethylamide (NHEt), N-propylamide, N-methylamide, and N-butylamide; and

a pharmaceutically acceptable carrier;

in an amount sufficient to treat the reproductive cancer in the subject.

2. The method of claim 1 , wherein the reproductive cancer is selected from the group consisting of: gynecological cancer, prostate cancer, benign prostatic hyperplasia, endometrial cancer, cervical cancer, ovarian cancer, breast cancer, melanoma, pancreatic cancer, and gastric cancer.

3. The method of claim 1 , wherein the subject is an animal.

4. The method of claim 3 , wherein the animal is selected from the group consisting of: human, chicken, cat, dog, pig, sheep, cow, and horse.

5. A method for reducing proliferation of one or more reproductive cancer cells comprising combining with the one or more reproductive cancer cells a therapeutically effective amount of an agent comprising a peptide sequence selected from the group consisting of:

i)

pLGlu-LHis-LTrp-LSer-LHis-DArg-LTrp-LTyr-

LPro- A ;

ii)

pLGlu-LHis-LTrp-LSer-LHis-DTrp-LTrp-LTyr-

LPro- A ;

iii)

pLGlu-LHis-LTrp-LSer-LTyr-DLys-LTrp-LGln-

LPro- A ;

iv)

pLGlu-LHis-LTrp-LSer-LTyr-DLys-LTrp-LLeu-

LPro- A ;

v)

pLGlu-LHis-LTrp-LSer-LTyr-DLys-LTrp-LTyr-

LPro- A ;

v-B)

pLGlu-LHis-LTrp-LSer-LTyr-DLys-LTrp-LArg-

LPro- A ;

vi)

pLGlu-LHis-LTrp-LSer-LTyr-DTrp-LTrp-LArg-

LPro- A ;

vii)

pLGlu-LHis-LTrp-LSer-LHis-DLys-LTrp-LTyr-

LPro- A ;

viii)

pLGlu-LHis-LTrp-LSer-LHis-DArg-LTrp-LTyr-

LPro. Y ;

ix)

pLGlu-LHis-LTrp-LSer-LHis-DArg-LLeu-LArg-

LPro- A ;

x)

pLGlu-LHis-LTrp-LSer-LHis-DTrp-LTrp-LArg-

LPro- A ;

xi)

pLGlu-LHis-LTrp-LSer-LHis-DTrp-LLeu-LArg-

LPro- A ;

xii)

pLGlu-LHis-LTrp-LSer-LHis-DTyr-LLeu-LArg-

LPro- A ;

xiii)

pLGlu-LHis-LTrp-LSer-LHis-DAla-LTrp-LTyr-

LPro- A ;

xiv)

pLGlu-LHis-LTrp-LSer-LHis-DSer-LTrp-LTyr-

LPro- A

wherein

R2 is any D-amino acid except DTrp;

Y selected from the group consisting of NHEt, NH 2 , DAla-NH 2 , and Z; and

A is selected from the group consisting of:

Z;

azaL-Gly;

azaL-Gly-Z;

D-Ala-Z;

L-Glu-Z;

D-Ala-L-Glu-Z;

D-Ala-D-Ala-Z;

βAla-Z;

L-Pro;

L-Pro-Z;

D-Ala-L-Gly-Z; and

L-Gly-Z;

wherein Z is selected from the group consisting of NH 2 , NHEt, N-propylamide, N-methylamide, and N-butylamide.

6. The method according to claim 5 , wherein the one or more reproductive cancer cells are from a reproductive cancer selected from the group consisting of: gynecological cancer, prostate cancer, benign prostatic hyperplasia, endometrial cancer, cervical cancer, ovarian cancer, breast cancer, melanoma, pancreatic cancer, and gastric cancer.

7. The method according to claim 5 , wherein the one or more reproductive cancer cells are from an animal's body.