Indole compounds

1. A compound having a formula or a pharmaceutically acceptable salt thereof;

wherein:

Q 1 is N and Q 2 , Q 3 , Q 4 and Q 5 are C;

a) P 1 , P 2 , P 3 , P 4 , P 5 and P 6 are C; or b) one of P 1 , P 2 , P 3 , P 4 , P 5 and P 6 is N and the rest are C; A and A′ taken together are ═O;

R 2 is C1-C3 alkyl;

each of R 4 , R 5 , R 6 and R 7 is independently: H, a halogen, —NO 2 , —CN, —C(O)OH, hydroxyl, an optionally independently substituted C 1 -C 5 alkyl, an optionally independently substituted C 2 -C 5 alkenyl, an optionally independently substituted C 2 -C 5 alkynyl, an optionally independently substituted C 1 -C 5 alkoxy, —C(O)NR a R b , or —NR a R b , wherein R a and R b are independently H, an optionally independently substituted C 1 -C 6 alkyl, or an optionally independently substituted C 3 -C 6 cycloalkyl;

each of R 8 , R 9 , R 10 , R 11 and R 12 , when bonded to C, is independently: H, a halogen, —NO 2 , —CN, —C(O)OH, hydroxyl, an optionally independently substituted C 1 -C 5 alkyl, an optionally independently substituted C 2 -C 5 alkenyl, an optionally independently substituted C 2 -C 5 alkynyl, an optionally independently substituted C 1 -C 5 alkoxy, —C(O)NR a R b , or —NR a R b , wherein R a and R b are independently H, an optionally independently substituted C 1 -C 6 alkyl, or an optionally independently substituted C 3 -C 6 cycloalkyl;

each of R 8 , R 9 , R 10 R 11 and R 12 , when bonded to N, is missing;

R 14 is selected from H, a halogen, —NO 2 , —CN, —C(O)OH, hydroxyl, an optionally independently substituted C 1 -C 5 alkyl, an optionally independently substituted C 2 -C 5 alkenyl, an optionally independently substituted C 2 -C 5 alkynyl, an optionally independently substituted C 1 -C 5 alkoxy, —C(O)NR a R b , or —NR a R b , wherein R a and R b are independently H, an optionally independently substituted C 1 -C 6 alkyl, or an optionally independently substituted C 3 -C 6 cycloalkyl;

R 16 is halogen or an optionally independently substituted methoxy and both R 13 and R 17 are H; and

R 15 is missing.

2. The compound of claim 1 , wherein one of P 1 , P 2 , P 3 , P 4 , P 5 and P 6 is N and the rest are C.

3. The compound of claim 1 , wherein P 1 , P 2 , P 3 , P 4 , P 5 and P 6 are C.

4. The compound of claim 1 , wherein R 2 is methyl.

5. The compound of claim 1 , wherein one or two of R 8 , R 9 , R 10 , R 11 and R 12 are halogen and the rest are H.

6. The compound of claim 5 , wherein one or two of R 8 , R 9 , R 10 , R 11 and R 12 are Cl or F and the rest are H.

7. The compound of claim 5 , wherein R 10 is halogen.

8. The compound of claim 7 , wherein R 10 is Cl or F and R 8 , R 9 , R 11 and R 12 are H.

9. The compound of claim 5 , wherein one of R 8 and R 12 is halogen and the other is H.

10. The compound of claim 5 , wherein R 10 is Cl or F, R 8 is Cl or F; and R 9 , R 11 and R 12 are H.

11. The compound of claim 1 , wherein R 4 and R 7 are H.

12. The compound of claim 1 , wherein R 6 is H.

13. The compound of either one of claims 11 and 12 wherein R 5 is selected from ethoxy, methoxy, ethyl, methyl, halogen and H.

14. The compound of claim 13 , wherein R 5 is selected from methoxy, methyl and H.

15. The compound of claim 14 , wherein R 5 is methoxy.

16. The compound of claim 14 , wherein R 5 is methyl.

17. The compound of claim 1 , wherein R 16 is —OCH 3 .

18. The compound of claim 1 , selected from the following list of compounds:

1-[(2,4-difluorophenyl)methyl]-N-(2-methoxy-4-pyridinyl)-2,5-dimethyl-α-oxo-1H-Indole-3-acetamide;

N-(2-chloro-4-pyridinyl)-5-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-α-oxo-1H-Indole-3-acetamide;

N-(2-chloro-4-pyridinyl)-1-[(4-fluorophenyl)methyl]-5-methoxy-2-methyl-α-oxo-1H-Indole-3-acetamide;

N-(2-chloro-4-pyridinyl)-1-[(2,4-dichlorophenyl)methyl]-5-methoxy-2-methyl-α-oxo-1H-Indole-3-acetamide;

5-methoxy-N-(2-methoxy-4-pyridinyl)-2-methyl-α-oxo-1-[[4-(trifluoromethyl)phenyl]methyl]-1H-Indole-3-acetamide;

5-methoxy-N-(2-methoxy-4-pyridinyl)-2-methyl-α-oxo-1-[[4-(trifluoromethoxy)phenyl]methyl]-1H-Indole-3-acetamide;

1-[(6-chloro-3-pyridinyl)methyl]-5-methoxy-N-(2-methoxy-4-pyridinyl)-2-methyl-α-oxo-1H-Indole-3-acetamide;

5-methoxy-N-(2-methoxy-4-pyridinyl)-2-methyl-1-[(4-methylphenyl)methyl]-α-oxo-1H-Indole-3-acetamide;

5-methoxy-1-[(4-methoxyphenyl)methyl]-N-(2-methoxy-4-pyridinyl)-2-methyl-α-oxo-1H-Indole-3-acetamide;

5-fluoro-1-[(4-fluorophenyl)methyl]-N-(2-methoxy-4-pyridinyl)-2-methyl-α-oxo-1H-Indole-3-acetamide;

5-chloro-1-[(4-fluorophenyl)methyl]-N-(2-methoxy-4-pyridinyl)-2-methyl-α-oxo-1H-Indole-3-acetamide;

5-chloro-1-[(4-chlorophenyl)methyl]-N-(2-methoxy-4-pyridinyl)-2-methyl-α-oxo-1H-Indole-3-acetamide;

1-[(4-fluorophenyl)methyl]-5-methoxy-N-(2-methoxy-4-pyridinyl)-2-methyl-α-oxo-1H-Indole-3-acetamide;

1-[(4-fluorophenyl)methyl]-N-(2-methoxy-4-pyridinyl)-2-methyl-α-oxo-1H-Indole-3-acetamide;

1-[(4-fluorophenyl)methyl]-N-(2-methoxy-4-pyridinyl)-2,5-dimethyl-α-oxo-1H-Indole-3-acetamide;

1-[(4-chlorophenyl)methyl]-5-methoxy-N-(2-methoxy-4-pyridinyl)-2-methyl-α-oxo-1H-Indole-3-acetamide;

1-[(4-chlorophenyl)methyl]-N-(2-fluoro-4-pyridinyl)-5-methoxy-2-methyl-α-oxo-1H-Indole-3-acetamide;

1-[(4-chlorophenyl)methyl]-5-fluoro-N-(2-methoxy-4-pyridinyl)-2-methyl-α-oxo-1H-Indole-3-acetamide;

1-[(4-chlorophenyl)methyl]-N-(2-chloro-4-pyridinyl)-5-fluoro-2-methyl-α-oxo-1H-Indole-3-acetamide;

1-[(4-chlorophenyl)methyl]-5-ethoxy-N-(2-methoxy-4-pyridinyl)-2-methyl-α-oxo-1H-Indole-3-acetamide;

1-[(4-chlorophenyl)methyl]-N-(2-chloro-4-pyridinyl)-5-ethoxy-2-methyl-α-oxo-1H-Indole-3-acetamide;

1-[(4-chlorophenyl)methyl]-N-(2-methoxy-4-pyridinyl)-2-methyl-α-oxo-1H-Indole-3-acetamide;

1-[(4-chlorophenyl)methyl]-N-(2-chloro-4-pyridinyl)-2-methyl-α-oxo-1H-Indole-3-acetamide;

1-[(4-chlorophenyl)methyl]-N-(2-methoxy-4-pyridinyl)-2,5-dimethyl-α-oxo-1H-Indole-3-acetamide;

1-[(4-chlorophenyl)methyl]-N-(2-chloro-4-pyridinyl)-2,5-dimethyl-α-oxo-1H-Indole-3-acetamide;

1-[(4-chloro-2-fluorophenyl)methyl]-5-methoxy-N-(2-methoxy-4-pyridinyl)-2-methyl-α-oxo-1H-Indole-3-acetamide;

1-[(4-chloro-2-fluorophenyl)methyl]-N-(2-methoxy-4-pyridinyl)-2-methyl-α-oxo-1H-Indole-3-acetamide;

1-[(4-chloro-2-fluorophenyl)methyl]-N-(2-methoxy-4-pyridinyl)-2,5-dimethyl-α-oxo-1H-Indole-3-acetamide;

1-[(3-chlorophenyl)methyl]-5-methoxy-N-(2-methoxy-4-pyridinyl)-2-methyl-α-oxo-1H-Indole-3-acetamide;

1-[(2-chlorophenyl)methyl]-5-methoxy-N-(2-methoxy-4-pyridinyl)-2-methyl-α-oxo-1H-Indole-3-acetamide;

1-[(2-chloro-4-fluorophenyl)methyl]-5-methoxy-N-(2-methoxy-4-pyridinyl)-2-methyl-α-oxo-1H-Indole-3-acetamide;

1-[(2-chloro-4-fluorophenyl)methyl]-N-(2-methoxy-4-pyridinyl)-2-methyl-α-oxo-1H-Indole-3-acetamide;

1-[(2-chloro-4-fluorophenyl)methyl]-N-(2-methoxy-4-pyridinyl)-2,5-dimethyl-α-oxo-1H-Indole-3-acetamide;

1-[(2,4-difluorophenyl)methyl]-5-methoxy-N-(2-methoxy-4-pyridinyl)-2-methyl-α-oxo-1H-Indole-3-acetamide;

1-[(2,4-difluorophenyl)methyl]-N-(2-methoxy-4-pyridinyl)-2-methyl-α-oxo-1H-Indole-3-acetamide;

1-[(2,4-dichlorophenyl)methyl]-5-methoxy-N-(2-methoxy-4-pyridinyl)-2-methyl-α-oxo-1H-Indole-3-acetamide;

1-[(2,4-dichlorophenyl)methyl]-5-fluoro-N-(2-methoxy-4-pyridinyl)-2-methyl-α-oxo-1H-Indole-3-acetamide;

1-[(2,4-dichlorophenyl)methyl]-N-(2-methoxy-4-pyridinyl)-2-methyl-α-oxo-1H-Indole-3-acetamide;

1-[(2,4-dichlorophenyl)methyl]-N-(2-methoxy-4-pyridinyl)-2,5-dimethyl-α-oxo-1H-Indole-3-acetamide;

5-methoxy-N-(2-methoxy-4-pyridinyl)-2-methyl-α-oxo-1-(phenylmethyl)-1H-Indole-3-acetamide;

N-(2-methoxy-4-pyridinyl)-2-methyl-α-oxo-1-(phenylmethyl)-1H-Indole-3-acetamide;

N-(2-methoxy-4-pyridinyl)-2,5-dimethyl-α-oxo-1-(phenylmethyl)-1H-Indole-3-acetamide

5-chloro-1-[(4-chlorophenyl)methyl]-N-(2-chloro-4-pyridinyl)-2-methyl-α-oxo-1H-Indole-3-acetamide; or

1-[(4-chlorophenyl)methyl]-N-(2-chloro-4-pyridinyl)-5-methoxy-2-methyl-α-oxo-1H-Indole-3-acetamide.