Pyridin-4-yl derivatives as immunomodulating agents

1. A compound of the Formula (I),

wherein

A represents

wherein the asterisks indicate the bond that is linked to the pyridine group of Formula (I);

R 1 represents C 1-4 -alkyl, or chloro;

R 2 represents C 1-5 -alkyl, C 1-4 -alkoxy, or C 3-6 -cycloalkyl;

R 3 represents hydrogen, C 1-4 -alkyl, C 1-4 -alkoxy, or halogen;

R 4 represents hydrogen, C 1-4 -alkyl, C 1-4 -alkoxy, halogen, trifluoromethyl, or trifluoromethoxy;

R 5 represents 2,3-dihydroxypropyl, di-(hydroxy-C 1-4 -alkyl)-C 1-4 -alkyl, —CH 2 —(CH 2 ) k —NHSO 2 R 53 , —(CH 2 ) n CH(OH)—CH 2 —NHSO 2 R 53 , —CH 2 —(CH 2 ) k —NHCOR 54 , —(CH 2 ) n CH(OH)—CH 2 —NHCOR 54 , —CH 2 —(CH 2 ) n —CONR 51 R 52 , —CO—NHR 51 , —(CH 2 ) n CH(OH)—CH 2 —NR 51 R 52 , hydroxy, hydroxy-C 2-5 -alkoxy, di-(hydroxy-C 1-4 -alkyl)-C 1-4 -alkoxy, 2,3-dihydroxy-propoxy, 2-hydroxy-3-methoxy-propoxy, —OCH 2 —(CH 2 ) m —NR 51 R 52 , —OCH 2 —CH(OH)—CH 2 —NR 51 R 52 , —OCH 2 —(CH 2 ) m —NHSO 2 R 53 , —OCH 2 —CH(OH)—CH 2 —NHSO 2 R 53 , —OCH 2 —(CH 2 ) m —NHCOR 54 , —OCH 2 —CH(OH)—CH 2 —NHCOR 54 ;

R 51 represents hydrogen, C 1-3 -alkyl, 2-hydroxyethyl, 2-hydroxy-1-hydroxymethyl-ethyl, 2,3-dihydroxypropyl, carboxymethyl, 1-(C 1-5 -alkylcarboxy)methyl, 2-carboxyethyl, or 2-(C 1-5 -alkylcarboxy)ethyl;

R 52 represents hydrogen, methyl, or ethyl;

R 53 represents C 1-3 -alkyl, methylamino, ethylamino, or dimethylamino;

R 54 represents hydroxymethyl, hydroxyethyl, aminomethyl, methylaminomethyl, dimethylaminomethyl, aminoethyl, 2-methylamino-ethyl, or 2-dimethylamino-ethyl;

k represents the integer 1, 2, or 3;

m represents the integer 1 or 2;

n represents 0, 1, or 2; and

R 6 represents hydrogen, C 1-4 -alkyl, or halogen;

in free or salt form.

2. The compound according to claim 1 , wherein A represents

wherein the asterisks indicate the bond that is linked to the pyridine group of Formula (I); in free or salt form.

3. The compound according to claim 1 , wherein A represents

wherein the asterisks indicate the bond that is linked to the pyridine group of Formula (I); in free or salt form.

4. The compound according to claim 1 , wherein A represents

wherein the asterisk indicates the bond that is linked to the pyridine group of Formula (I), in free or salt form.

5. The compound according to claim 1 , wherein R 1 represents C 1-4 -alkyl; in free or salt form.

6. The compound according to claim 1 , wherein R 1 represents methyl or ethyl; in free or salt form.

7. The compound according to claim 1 , wherein R 1 represents methyl; in free or salt form.

8. The compound according to claim 1 , wherein R 2 represents C 1-5 -alkyl, C 1-3 -alkoxy, or cyclopentyl; in free or salt form.

9. The compound according to claim 1 , wherein R 2 represents C 2-5 -alkyl; in free or salt form.

10. The compound according to claim 1 , wherein R 2 represents ethyl, n-propyl, isopropyl, isobutyl, or 3-pentyl; in free or salt form.

11. The compound according to claim 1 , wherein at least one of R 3 , R 4 and R 6 represents a group other than hydrogen; in free or salt form.

12. The compound according to claim 1 , wherein R 3 represents hydrogen; in free or salt form.

13. The compound according to claim 1 , wherein R 3 represents hydrogen; and R 4 represents C 1-4 -alkyl, or C 1-4 -alkoxy; and R 6 represents C 1-4 -alkyl, or halogen; in free or salt form.

14. The compound according to claim 1 , wherein R 3 represents hydrogen; and R 4 represents C 1-3 -alkyl, or methoxy; and R 6 represents methyl, ethyl, or chloro; in free or salt form.

15. The compound according to claim 1 , wherein R 5 represents 2,3-dihydroxypropyl, —CH 2 —(CH 2 ) k —NHCOR 54 , —(CH 2 ) n CH(OH)—CH 2 —NHCOR 54 , —CH 2 —(CH 2 ) n —CONR 51 R 52 , —CO—NHR 51 , —(CH 2 ) n CH(OH)—CH 2 —NR 51 R 52 , hydroxy-C 2-5 -alkoxy, di-(hydroxy-C 1-4 -alkyl)-C 1-4 -alkoxy, 2,3-dihydroxy-propoxy, 2-hydroxy-3-methoxy-propoxy, —OCH 2 —(CH 2 ) m —NR 51 R 52 , —OCH 2 —CH(OH)—CH 2 —NR 51 R 52 , —OCH 2 —(CH 2 ) m —NHCOR 54 , or —OCH 2 —CH(OH)—CH 2 —NHCOR 54 ; in free or salt form.

16. The compound according to claim 1 , wherein R 5 represents 3-hydroxy-2-hydroxymethyl-propoxy, 2,3-dihydroxy-propoxy or —OCH 2 —CH(OH)—CH 2 —NHCOR 54 ; in free or salt form.

17. The compound according to claim 1 selected from the group consisting of:

N-(3-{4-[5-(2-Chloro-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2,6-dimethyl-phenoxy}-2-hydroxy-propyl)-2-hydroxy-acetamide;

3-{4-[5-(2-Chloro-6-isobutyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2,6-dimethyl-phenoxy}-propane-1,2-diol;

N-(3-{4-[5-(2-Chloro-6-isobutyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2,6-dimethyl-phenoxy}-2-hydroxy-propyl)-2-hydroxy-acetamide;

3-{4-[5-(2-Ethyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2,6-dimethyl-phenoxy}-propane-1,2-diol;

3-{4-[5-(2-Isobutyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2,6-dimethyl-phenoxy}-propane-1,2-diol;

2-Hydroxy-N-(2-hydroxy-3-{4-[5-(2-isobutyl-6-methyl-pyridin-4-yl)1,2,4]oxadiazol-3-yl]-2,6-dimethyl-phenoxy}-propyl)-acetamide;

3-{2-Ethyl-4-[5-(2-isobutyl-6-methyl-pyridin-4-yl)1,2,4]oxadiazol-3-yl]-6-methyl-phenoxy}-propane-1,2-diol;

2-Ethyl-4-[5-(2-isobutyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenol;

(R)-3-{2-Ethyl-4-[5-(2-isobutyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenoxy}-propane-1,2-diol;

(S)-3-{2-Ethyl-4-[5-(2-isobutyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenoxy}-propane-1,2-diol;

2-{2-Ethyl-4-[5-(2-isobutyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenoxymethyl}-propane-1,3-diol;

2-{2-Ethyl-4-[5-(2-isobutyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenoxy}-ethanol;

3-{2-Ethyl-4-[5-(2-isobutyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenoxy}-propan-1-ol;

N-(3-{2-Ethyl-4-[5-(2-isobutyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenoxy}-2-hydroxy-propyl)-2-hydroxy-acetamide;

3-{4-[5-(2,6-Diisobutyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2,6-dimethyl-phenoxy}-propane-1,2-diol;

3-{4-[5-(2-Chloro-6-isopropoxy-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2,6-dimethyl-phenoxy}-propane-1,2-diol;

N-(3-{4-[5-(2-Chloro-6-isopropoxy-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2,6-dimethyl-phenoxy}-2-hydroxy-propyl)-2-hydroxy-acetamide;

3-{4-[5-(2-Ethoxy-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2,6-dimethyl-phenoxy}-propane-1,2-diol;

3-{4-[5-(2-Isopropoxy-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2,6-dimethyl-phenoxy}-propane-1,2-diol;

2-Hydroxy-N-(2-hydroxy-3-{4-[5-(2-isopropoxy-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2,6-dimethyl-phenoxy}-propyl)-acetamide;

4-[5-(2-Ethyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2,6-dimethyl-phenol;

(R)-3-{4-[5-(2-Ethyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2,6-dimethyl-phenoxy}-propane-1,2-diol;

(R)-3-{2-Chloro-4-[5-(2-ethyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenoxy}-propane-1,2-diol;

(S)-3-{4-[5-(2-Ethyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2,6-dimethyl-phenoxy}-propane-1,2-diol;

(S)-3-{2-Chloro-4-[5-(2-ethyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenoxy}-propane-1,2-diol;

(S)-3-{2-Chloro-4-[5-(2-ethyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-6-methoxy-phenoxy}-propane-1,2-diol;

N-(3-{4-[5-(2-Ethyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2,6-dimethyl-phenoxy}-2-hydroxy-propyl)-2-hydroxy-acetamide;

N-((R)-3-{2-Ethyl-4-[5-(2-ethyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenoxy}-2-hydroxy-propyl)-2-hydroxy-acetamide;

N-((S)-3-{2-Ethyl-4-[5-(2-ethyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenoxy}-2-hydroxy-propyl)-2-hydroxy-acetamide;

N-(3-{4-[5-(2-Ethyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-methyl-6-propyl-phenoxy}-2-hydroxy-propyl)-2-hydroxy-acetamide;

N-((S)-3-{4-[5-(2-Ethyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-methyl-6-propyl-phenoxy}-2-hydroxy-propyl)-2-hydroxy-acetamide;

N-((R)-3-{2-Chloro-4-[5-(2-ethyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenoxy}-2-hydroxy-propyl)-2-hydroxy-acetamide;

N-((S)-3-{2-Chloro-4-[5-(2-ethyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenoxy}-2-hydroxy-propyl)-2-hydroxy-acetamide;

N-((R)-3-{2-Chloro-4-[5-(2-ethyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-6-methoxy-phenoxy}-2-hydroxy-propyl)-2-hydroxy-acetamide;

N-((S)-3-{2-Chloro-4-[5-(2-ethyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-6-methoxy-phenoxy}-2-hydroxy-propyl)-2-hydroxy-acetamide;

N-(3-{4-[5-(2-Ethyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-methoxy-6-methyl-phenoxy}-2-hydroxy-propyl)-2-hydroxy-acetamide;

N-((S)-3-{2-Ethyl-4-[3-(2-ethyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-5-yl]-6-methyl-phenoxy}-2-hydroxy-propyl)-2-hydroxy-acetamide;

N-((S)-3-{4-[5-(2-Ethyl-6-methyl-pyridin-4-yl)-[1,3,4]oxadiazol-2-yl]-2,6-dimethyl-phenoxy}-2-hydroxy-propyl)-2-hydroxy-acetamide;

2,6-Dimethyl-4-[5-(2-methyl-6-propyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-phenol;

2-Ethyl-6-methyl-4-[5-(2-methyl-6-propyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-phenol;

(R)-3-{2,6-Dimethyl-4-[5-(2-methyl-6-propyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-phenoxy}-propane-1,2-diol;

(S)-3-{2,6-Dimethyl-4-[5-(2-methyl-6-propyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-phenoxy}-propane-1,2-diol;

(R)-3-{2-Ethyl-6-methyl-4-[5-(2-methyl-6-propyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-phenoxy}-propane-1,2-diol;

(S)-3-{2-Ethyl-6-methyl-4-[5-(2-methyl-6-propyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-phenoxy}-propane-1,2-diol;

(R)-3-{2-Chloro-6-methoxy-4-[5-(2-methyl-6-propyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-phenoxy}-propane-1,2-diol;

(S)-3-{2-Chloro-6-methoxy-4-[5-(2-methyl-6-propyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-phenoxy}-propane-1,2-diol;

N-(3-{2,6-Dimethyl-4-[5-(2-methyl-6-propyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-phenoxy}-2-hydroxy-propyl)-2-hydroxy-acetamide;

N-((S)-3-{2,6-Dimethyl-4-[5-(2-methyl-6-propyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-phenoxy}-2-hydroxy-propyl)-2-hydroxy-acetamide;

N-((R)-3-{2-Ethyl-6-methyl-4-[5-(2-methyl-6-propyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-phenoxy}-2-hydroxy-propyl)-2-hydroxy-acetamide;

N-((S)-3-{2-Ethyl-6-methyl-4-[5-(2-methyl-6-propyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-phenoxy}-2-hydroxy-propyl)-2-hydroxy-acetamide;

N-((R)-3-{2-Chloro-6-methoxy-4-[5-(2-methyl-6-propyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-phenoxy}-2-hydroxy-propyl)-2-hydroxy-acetamide;

N-((S)-3-{2,6-Dimethyl-4-[5-(2-methyl-6-propyl-pyridin-4-yl)-[1,3,4]oxadiazol-2-yl]-phenoxy}-2-hydroxy-propyl)-2-hydroxy-acetamide;

N-((R)-3-{2-Ethyl-6-methyl-4-[5-(2-methyl-6-propyl-pyridin-4-yl)-[1,3,4]oxadiazol-2-yl]-phenoxy}-2-hydroxy-propyl)-2-hydroxy-acetamide;

N-((S)-3-{2-Ethyl-6-methyl-4-[5-(2-methyl-6-propyl-pyridin-4-yl)-[1,3,4]oxadiazol-2-yl]-phenoxy}-2-hydroxy-propyl)-2-hydroxy-acetamide;

2-{2-Ethyl-4-[5-(2-isopropyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenoxy}-ethanol;

(S)-3-{2-Ethyl-4-[5-(2-isopropyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenoxy}-propane-1,2-diol;

N-(3-{2-Ethyl-4-[5-(2-isopropyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenoxy}-2-hydroxy-propyl)-2-hydroxy-acetamide;

2-Hydroxy-N-((S)-2-hydroxy-3-{4-[5-(2-isopropyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-methyl-6-propyl-phenoxy}-propyl)-acetamide;

3-{2-Chloro-4-[5-(2-isobutyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenoxy}-propane-1,2-diol;

3-{2-Chloro-4-[5-(2-isobutyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-6-methoxy-phenoxy}-propane-1,2-diol;

3-{2-Bromo-4-[5-(2-isobutyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-phenoxy}-propane-1,2-diol;

1-{2-Chloro-4-[5-(2-isobutyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-6-methoxy-phenoxy}-3-(2-hydroxy-ethylamino)-propan-2-ol;

2-Hydroxy-N-(2-hydroxy-3-{4-[5-(2-isobutyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-3-methyl-phenoxy}-propyl)-acetamide;

N-(3-{2-Chloro-4-[5-(2-isobutyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenoxy}-2-hydroxy-propyl)-2-hydroxy-acetamide;

N-(3-{2-Chloro-4-[5-(2-isobutyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-6-methoxy-phenoxy}-2-hydroxy-propyl)-2-hydroxy-acetamide;

2-Chloro-4-[5-(2-isobutyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-6-methoxy-phenol;

(S)-3-{4-[5-(2-Isobutyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-methyl-6-propyl-phenoxy}-propane-1,2-diol;

2-Hydroxy-N-(2-hydroxy-3-{4-[5-(2-isobutyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-3-methoxy-phenoxy}-propyl)-acetamide;

2-Hydroxy-N-((S)-2-hydroxy-3-{4-[5-(2-isobutyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-methyl-6-propyl-phenoxy}-propyl)-acetamide;

2-Hydroxy-N-(2-hydroxy-3-{4-[5-(2-isobutyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-methoxy-6-methyl-phenoxy}-propyl)-acetamide;

N-((R)-3-{2-Chloro-4-[5-(2-isobutyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-6-methoxy-phenoxy}-2-hydroxy-propyl)-2-hydroxy-acetamide;

N-((S)-3-{2-Chloro-4-[5-(2-isobutyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-6-methoxy-phenoxy}-2-hydroxy-propyl)-2-hydroxy-acetamide;

(R)-3-{2-Ethyl-4-[3-(2-isobutyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-5-yl]-6-methyl-phenoxy}-propane-1,2-diol;

(S)-3-{2-Ethyl-4-[3-(2-isobutyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-5-yl]-6-methyl-phenoxy}-propane-1,2-diol;

2-Hydroxy-N-((R)-2-hydroxy-3-{4-[5-(2-isobutyl-6-methyl-pyridin-4-yl)-[1,3,4]oxadiazol-2-yl]-2,6-dimethyl-phenoxy}-propyl)-acetamide;

2-Hydroxy-N-((S)-2-hydroxy-3-{4-[5-(2-isobutyl-6-methyl-pyridin-4-yl)-[1,3,4]oxadiazol-2-yl]-2,6-dimethyl-phenoxy}-propyl)-acetamide;

N-((R)-3-{2-Ethyl-4-[5-(2-isobutyl-6-methyl-pyridin-4-yl)-[1,3,4]oxadiazol-2-yl]-6-methyl-phenoxy}-2-hydroxy-propyl)-2-hydroxy-acetamide;

N-((S)-3-{2-Ethyl-4-[5-(2-isobutyl-6-methyl-pyridin-4-yl)-[1,3,4]oxadiazol-2-yl]-6-methyl-phenoxy}-2-hydroxy-propyl)-2-hydroxy-acetamide;

N-((S)-3-{2-Chloro-4-[5-(2-isobutyl-6-methyl-pyridin-4-yl)-[1,3,4]oxadiazol-2-yl]-6-methoxy-phenoxy}-2-hydroxy-propyl)-2-hydroxy-acetamide;

2-Ethyl-4-{5-[2-(1-ethyl-propyl)-6-methyl-pyridin-4-yl]-[1,2,4]oxadiazol-3-yl}-6-methyl-phenol;

(R)-3-(2-Ethyl-4-{5-[2-(1-ethyl-propyl)-6-methyl-pyridin-4-yl]-[1,2,4]oxadiazol-3-yl}-6-methyl-phenoxy)-propane-1,2-diol;

(S)-3-(2-Ethyl-4-{5-[2-(1-ethyl-propyl)-6-methyl-pyridin-4-yl]-[1,2,4]oxadiazol-3-yl}-6-methyl-phenoxy)-propane-1,2-diol;

(R)-3-(4-{5-[2-(1-Ethyl-propyl)-6-methyl-pyridin-4-yl]-[1,2,4]oxadiazol-3-yl}-2-methyl-6-propyl-phenoxy)-propane-1,2-diol;

(S)-3-(4-{5-[2-(1-Ethyl-propyl)-6-methyl-pyridin-4-yl]-[1,2,4]oxadiazol-3-yl}-2-methyl-6-propyl-phenoxy)-propane-1,2-diol;

N-[(R)-3-(2-Ethyl-4-{5-[2-(1-ethyl-propyl)-6-methyl-pyridin-4-yl]-[1,2,4]oxadiazol-3-yl}-6-methyl-phenoxy)-2-hydroxy-propyl]-2-hydroxy-acetamide;

N-[(S)-3-(2-Ethyl-4-{5-[2-(1-ethyl-propyl)-6-methyl-pyridin-4-yl]-[1,2,4]oxadiazol-3-yl}-6-methyl-phenoxy)-2-hydroxy-propyl]-2-hydroxy-acetamide;

N-[(R)-3-(4-{5-[2-(1-Ethyl-propyl)-6-methyl-pyridin-4-yl]-[1,2,4]oxadiazol-3-yl}-2-methyl-6-propyl-phenoxy)-2-hydroxy-propyl]-2-hydroxy-acetamide;

N-[(S)-3-(4-{5-[2-(1-Ethyl-propyl)-6-methyl-pyridin-4-yl]-[1,2,4]oxadiazol-3-yl}-2-methyl-6-propyl-phenoxy)-2-hydroxy-propyl]-2-hydroxy-acetamide;

3-{4-[5-(2,6-Diethyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2,6-dimethyl-phenoxy}-propane-1,2-diol;

3-{4-[5-(2,6-Diethyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methyl-phenoxy}-propane-1,2-diol;

N-((S)-3-{4-[5-(2,6-Diethyl-pyridin-4-yl)-[1,3,4]oxadiazol-2-yl]-2,6-dimethyl-phenoxy}-2-hydroxy-propyl)-2-hydroxy-acetamide;

N-(3-{4-[5-(2-Ethoxy-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2,6-dimethyl-phenoxy}-2-hydroxy-propyl)-2-hydroxy-acetamide;

(R)-3-{2-Ethyl-4-[5-(2-isobutyl-6-methoxy-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenoxy}-propane-1,2-diol;

(S)-3-{2-Ethyl-4-[5-(2-isobutyl-6-methoxy-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenoxy}-propane-1,2-diol;

N-((R)-3-{2-Ethyl-4-[5-(2-isobutyl-6-methoxy-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenoxy}-2-hydroxy-propyl)-2-hydroxy-acetamide;

N-((S)-3-{2-Ethyl-4-[5-(2-isobutyl-6-methoxy-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenoxy}-2-hydroxy-propyl)-2-hydroxy-acetamide;

(R)-3-{4-[5-(2-Cyclopentyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methyl-phenoxy}-propane-1,2-diol;

(S)-3-{4-[5-(2-Cyclopentyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methyl-phenoxy}-propane-1,2-diol;

N-((R)-3-{4-[5-(2-Cyclopentyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methyl-phenoxy}-2-hydroxy-propyl)-2-hydroxy-acetamide; and

N-((S)-3-{4-[5-(2-Cyclopentyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methyl-phenoxy}-2-hydroxy-propyl)-2-hydroxy-acetamide;

in free or salt form.

18. A pharmaceutical composition comprising a compound according to claim 1 , in free or pharmaceutically acceptable salt form, and a pharmaceutically acceptable carrier.