Granted Patent B2

US 8,300,910 · App. 12/311,153 · Granted Oct 30, 2012

Abstract

Claims (17)

1. A method for the analysis of three dimensional image data representing an articular cartilage to extract a quantitative parameter indicative of joint pathology, which method comprises determining from the data a measure representative of cartilage homogeneity, and further comprising comparing the measured value for the joint with measured values previously established in respect of healthy joints and/or in respect of joints characterised by a pathology, wherein said measure representative of cartilage homogeneity is the entropy, the mean, the standard deviation or the uniformity of measured intensities within a region of interest of the image.

2. A method as claimed in claim 1 , wherein said measure is the entropy of the measured intensities within the region of interest.

3. A method as claimed in claim 1 , further comprising partitioning the region of interest into at least two sub-regions and comparing the measured value representative of homogeneity obtained from the sub-region that has previously been found to best discriminate between healthy joints and joints characterised by a pathology.

4. A method as claimed in claim 1 , further comprising regularising data representative of said measured intensities within said region of interest to enhance measurements derived from said signals.

5. A method as claimed in claim 1 , wherein said region of interest lies in a load bearing area of said cartilage.

6. A method as claimed in claim 1 , wherein said cartilage is a knee cartilage.

7. A method as claimed in claim 6 , wherein said knee cartilage is a tibial cartilage.

8. A method as claimed in claim 7 , wherein said tibial cartilage is a medial tibial cartilage.

9. A method as claimed in claim 8 , wherein said partitioned region within said region of interest is a medial area of the medial tibial cartilage.

10. A method as claimed in preceding claim 1 , wherein a comparison of said quantitative parameter is made both with values of the quantitative parameter previously established in respect of healthy joints and with values of said quantitative parameter previously established in respect of joints characterised by a pathology.

11. A method as claimed in claim 1 , wherein said pathology is osteoarthritis, rheumatoid arthritis, villonodular synovitis, Lipoid dematoarthritis (Multicentric reticulohistiocytosis), Enteropathic arthritis, hemophilia (intraarticular bleeding), Gout, Familial Mediterranean fever, Pseudogout, Ochronotic arthropathy, Secondary osteoarthritis, Syphilis (tabes dorsalis), Pyrogenic arthritis, Tuberculous arthritis or Fungal arthritis.

12. A method as claimed in claim 1 , wherein said three dimensional scan data is produced by magnetic resonance imaging (MRI).

13. A method as claimed in claim 1 , wherein the quantitative parameter is calculated from the medial part of the tibial medial cartilage.

14. A method as claimed in claim 1 , further comprising analysing said scan data to perform an automatic segmentation of image data representing cartilage from bone and other background prior to extracting said quantitative parameter.

15. A method as claimed in claim 1 , wherein a value for said quantitative parameter which is indicative of more homogeneity than that established for healthy joints is taken as indicative of probable joint pathology.

16. A method as claimed in claims 1 , further comprising determining from three dimensional image data representing the same articular cartilage at a subsequent period in time a second said measure representative of cartilage homogeneity and comparing said second measure with the measure determined from the earlier data, wherein a change in the measure representative of cartilage homogeneity is indicative of progression of osteoarthritis.

17. A method as claimed in claims 1 , wherein the measure representative of cartilage homogeneity is used as a prognostic biomarker of early osteoarthritis.

Assignments (23)