Spray dried formulation
View Patent ↗Pharmaceutical compositions comprising a poorly water soluble ionizable drug, a cationic species and a dispersion polymer are disclosed, together with a process for forming the compositions. The neutral form of the drug has (i) a solubility of less than 1 mg/ml, in aqueous solution at a pH between 6 and 7, (ii) a solubility of less than 20 mg/mL in a volatile organic solvent, and (iii) an acidic pKa value of greater than 5. At least 90 wt % of the drug in the solid dispersion being in a non-crystalline form. The drug, the cationic species, and the dispersion polymer constitute at least 80 wt % of the solid dispersion.
1. A solid dispersion, comprising:
(a) a poorly water soluble ionizable drug, the neutral form of said drug having
(i) a solubility of less than 1 mg/mL in aqueous solution at a pH between 6 and 7,
(ii) a solubility of less than 20 mg/mL in a volatile organic solvent, and
(iii) an acidic pKa value of greater than 5;
(b) a cationic species; and
(c) a dispersion polymer
wherein said drug is not 6-amino-9-benzyl-8-oxo-8,9-di hydro-7H-purine-2-carboxylic acid cyclopropylmethyl-amide, at least 90 wt % of said drug in said solid dispersion is in a non-crystalline form and said drug, said cationic species, and said dispersion polymer constitute at least 80 wt % of said solid dispersion, wherein said dispersion polymer is selected from the group consisting of hydroxypropyl methylcellulose, hydroxypropyl methylcellulose acetate, hydroxypropyl cellulose, poloxamers, neutralized forms of hydroxypropyl methylcellulose acetate succinate, neutralized forms of hydroxypropyl methylcellulose phthalate, neutralized forms of cellulose acetate phthalate, neutralized forms of cellulose acetate trimellitate, neutralized forms of carboxymethyl ethyl cellulose, and mixtures thereof.
2. The solid dispersion of claim 1 wherein said drug in its neutral form exists in a keto/enol form.
3. The solid dispersion of claim 1 wherein said drug has an acidic pKa value of greater than 6.
4. The solid dispersion of claim 1 wherein said drug has a ratio of melting point to glass-transition temperature in degrees Kelvin of greater than 1.4.
5. The solid dispersion of claim 1 wherein said dispersion polymer is hydroxypropyl methylcellulose.
6. The solid dispersion of claim 1 wherein said cationic species is selected from the group consisting of cations of potassium, sodium, calcium, magnesium, aluminum, ammonium, and mixtures thereof.
7. The solid dispersion of claim 1 wherein said dispersion has a glass transition temperature that is different than the glass transition temperature of either said drug alone or said polymer alone.