Anti-infective alcohol catheter solution with chlorhexidine treated catheter
Implantable catheters treated with chlorhexidine and methods for disinfecting the catheters with alcohol are provided.
1 . An implantable catheter comprising a lumen that is at least partly filled with a solution comprising alcohol, wherein at least an inner surface of the lumen is impregnated or coated with chlorhexidine.
2 . The implantable catheter of claim 1 , wherein the catheter is impregnated with chlorhexidine.
3 . The implantable catheter of claim 1 , wherein an inner surface of the lumen is coated with chlorhexidine.
4 . The implantable catheter of claim 1 , wherein chlorhexidine is present in a concentration of 0.1%-10% by weight of the catheter.
5 . The implantable catheter of claim 1 , wherein chlorhexidine is present in a concentration of 0.5%-5% by weight of the catheter.
6 . The implantable catheter of claim 1 , wherein chlorhexidine has a concentration of about 200 micrograms per cm length of catheter.
7 . The implantable catheter of claim 1 , wherein alcohol is present in the solution in a concentration of 25-30%.
8 . The implantable catheter of claim 1 , wherein chlorhexidine is present in a concentration that, in the absence of alcohol, is subinhibitory for attachment or growth of microorganisms on the catheter.
9 . The implantable catheter of claim 1 , wherein alcohol is present in a concentration that, in the absence of chlorhexidine, is subinhibitory for attachment or growth of microorganisms on the catheter.
10 . The implantable catheter of claim 1 , wherein chlorhexidine is present in a concentration that, in the absence of alcohol, is subinhibitory for attachment or growth of microorganisms on the catheter, and wherein alcohol is present in a concentration that, in the absence of chlorhexidine, is subinhibitory for attachment or growth of microorganisms on the catheter.
11 . The implantable catheter of claim 8 , wherein chlorhexidine is present in a concentration that is subinhibitory for attachment or growth of Staphylococcus aureus on the catheter.
12 . The implantable catheter of claim 9 , wherein alcohol is present in a concentration that is subinhibitory for attachment or growth of Staphylococcus aureus on the catheter.
13 . The implantable catheter of claim 1 , wherein chlorhexidine comprises chlorhexidine base.
14 . The implantable catheter of claim 1 , wherein chlorhexidine comprises chlorhexidine salt.
15 . The implantable catheter of claim 1 , wherein chlorhexidine comprises chlorhexidine succinate.
16 . The implantable catheter of claim 1 , wherein at least an inner surface of the lumen is impregnated or coated with a combination of chlorhexidine and an antimicrobial dye.
17 . The implantable catheter of claim 16 , wherein at least an inner surface of the lumen is impregnated or coated with gendine, genlenol, genlosan, or genfoctol.
18 . The implantable catheter of claim 1 , wherein the catheter is further impregnated with or coated with a substance selected from the group consisting of one or more of minocycline, triclosan, ethylene diamine tetraacetic acid (EDTA), citrate, taurolidine, 5-Fluorouracil, miconazole, ketoconazole, chlorohexidine and itraconazole.
19 . The implantable catheter of claim 1 , wherein the alcohol is selected from the group consisting of one or more of ethanol, propanol, isopropanol and butanol.
20 . The implantable catheter of claim 1 , wherein the alcohol is ethanol.
21 . The implantable catheter of claim 1 , wherein the solution further comprises an anti-coagulant.
22 . The implantable catheter of claim 1 , wherein the catheter is implanted in a subject.
23 . The implantable catheter of claim 22 , wherein the catheter is implanted in a blood vessel or a body cavity.
24 . The implantable catheter of claim 1 , wherein the catheter is a transcutaneous catheter.
25 . An implantable catheter that can be disinfected in vivo with alcohol, wherein the catheter comprises a lumen with an inner surface that is impregnated or coated with chlorhexidine and wherein chlorhexidine is present in the catheter in a concentration that is subinhibitory for attachment or growth of microorganisms on the catheter.
26 - 41 . (canceled)
42 . A method of disinfecting or preventing infection of a catheter implanted in a subject, the method comprising flushing a lumen of the catheter with a solution comprising alcohol, wherein at least an inner surface of the lumen is impregnated or coated with chlorhexidine.
43 - 64 . (canceled)