Angiotensin II receptor antagonists

1. A compound having the structure

wherein

Y is —Y 1 —Y 2 —Y 3 —Y 4 —Y 5 —;

Y 1 is C(O) or C(R 1 R 2 );

Y 2 is O, C(O), P(O)(OH) or CH 2 , provided that when Y 1 is C(O), Y 2 is not C(O);

R 1 is selected from the group consisting of hydrogen and C 1-4 alkyl;

R 2 is selected from the group consisting of hydrogen, C 1-4 alkyl, and —OC(O)C 1-4 alkyl;

Y 3 is O, C(O) or CH 2 , provided that when Y 2 is C(O), then Y 3 is not C(O), and further provided that when Y 2 is O, then Y 3 is not O;

Y 4 is O or CH 2 or is absent, provided that when Y 3 is O, then Y 4 is not O;

Y 5 is —(CH 2 ) 1-2 —(X) 0-1 —(CH 2 ) 0-1 — or is absent;

X is —O— or —CR 3 R 4 —; and

R 3 and R 4 are independently selected from the group consisting of hydrogen and C 1 -C 4 alkyl;

or a pharmaceutically acceptable salt thereof.

2. A compound of claim 1 , wherein Y 1 is C(O).

3. A compound of claim 1 , wherein Y 2 is CH 2 .

4. A compound of claim 1 , wherein Y 3 is CH 2 .

5. A compound of claim 1 , wherein Y 4 is CH 2 .

6. A compound of claim 1 , wherein Y 5 is absent.

7. A compound having the structure

or a pharmaceutically acceptable salt or hydrate thereof.

8. A compound of claim 7 having the structure

or a pharmaceutically acceptable salt or hydrate thereof.

9. A compound of claim 7 having the structure

or a pharmaceutically acceptable salt or hydrate thereof.

10. A pharmaceutical composition comprising a compound of claim 7 and a pharmaceutically acceptable carrier.

11. A pharmaceutical composition comprising a compound of claim 7 , a diuretic and a pharmaceutically acceptable carrier.

12. A method for treating hypertension in a patient which comprises administering to the patient a therapeutically effective amount of the composition of claim 10 .