Pharmaceutical composition containing low-substituted hydroxypropyl cellulose

1. A pharmaceutical composition comprising:

a compound represented by formula (I):

or a pharmacologically acceptable salt thereof;

a low-substituted hydroxypropyl cellulose;

hydroxypropyl cellulose;

lactose; and

magnesium stearate,

wherein the amount of the low-substituted hydroxypropyl cellulose is present in an amount of 10.0 to 30.0% by weight, hydroxypropyl cellulose is present in an amount of 2.5 to 10.0% by weight and magnesium stearate is present in an amount of 0.5 to 3.0% by weight with respect to a total amount of the pharmaceutical composition.

2. The pharmaceutical composition according to claim 1 , wherein the compound represented by the formula (I) or the pharmacologically acceptable salt thereof is a compound represented by formula (Ia):

3. The pharmaceutical composition according to claim 2 , wherein the composition is formed by a method comprising formulating by a direct compression method.

4. The pharmaceutical composition according to claim 1 , wherein the composition is formed by a method comprising formulating by a direct compression method.

5. The pharmaceutical composition according to claim 1 , wherein hydroxypropyl cellulose is present in an amount of 5.0 to 10.0% by weight with respect to the total amount of the pharmaceutical composition.

6. The pharmaceutical composition according to claim 2 , wherein hydroxypropyl cellulose is present in an amount of 5.0 to 10.0% by weight with respect to the total amount of the pharmaceutical composition.

7. The pharmaceutical composition according to claim 2 , wherein magnesium stearate is present in an amount of 1.0 to 3.0% by weight with respect to the total amount of the pharmaceutical composition.

8. The pharmaceutical composition according to claim 6 , wherein magnesium stearate is present in an amount of 1.0 to 3.0% by weight with respect to the total amount of the pharmaceutical composition.

9. The pharmaceutical composition according to claim 2 , wherein lactose is present in an amount of 44.0 to 87.0% by weight with respect to the total amount of the pharmaceutical composition.

10. The pharmaceutical composition according to claim 2 , wherein the low-substituted hydroxypropyl cellulose is present in an amount of 10.0 to 20.0% by weight with respect to the total amount of the pharmaceutical composition.

11. The pharmaceutical composition according to claim 10 , wherein magnesium stearate is present in an amount of 1.0 to 3.0% by weight with respect to the total amount of the pharmaceutical composition.

12. The pharmaceutical composition according to claim 11 , wherein hydroxypropyl cellulose is present in an amount of 5.0 to 10.0% by weight with respect to the total amount of the pharmaceutical composition.

13. The pharmaceutical composition according to claim 12 , wherein lactose is present in an amount of 44.0 to 84.0% by weight with respect to the total amount of the pharmaceutical composition.

14. The pharmaceutical composition according to claim 2 , wherein the low-substituted hydroxypropyl cellulose is present in an amount of 10.0% by weight, magnesium stearate is present in an amount of 1.0% by weight and hydroxypropyl cellulose is present in an amount of 5.0% by weight, with respect to the total amount of the pharmaceutical composition.

15. The pharmaceutical composition according to claim 2 , wherein the low-substituted hydroxypropyl cellulose is present in an amount of 20.0% by weight, magnesium stearate is present in an amount of 1.0% by weight and hydroxypropyl cellulose is present in an amount of 5.0% by weight, with respect to the total amount of the pharmaceutical composition.