Polymer containing calcium sulfate particles for bone augmentation
Polymer containing calcium sulfate particles as an implant material are provided. The polymer containing calcium sulfate particles include a calcium sulfate compound coated with a therapeutic polymer containing salicylate, with a coating thickness from about 2 μm to about 50 μm. The therapeutic polymer in the particles is in a range from about 0.1% to about 22% (w/w). The resorption of the particles in vivo is from about four weeks to about twenty weeks. The polymer containing calcium sulfate particles can be used as an implant material for bone repairing and bone augmentation.
1. Polymer containing calcium sulfate particles as an implant material, comprising a calcium sulfate compound selected from the group consisting of calcium sulfate dihydrate, calcium sulfate hemihydrate and a combination thereof, coated with at least one resorbable polymer consisting of polymer containing salicylate, with a coating thickness from about 2 μm to about 50 μm.
2. The polymer containing calcium sulfate particles of claim 1 , wherein said polymer containing salicylate is in a range from about 0.1% to about 22% (w/w).
3. The polymer containing calcium sulfate particles of claim 1 , wherein resorption of said particles in a recipient site is from about four weeks to about twenty weeks.
4. The polymer containing calcium sulfate particles of claim 1 , wherein said particles are further coated with another resorbable polymer.
5. The polymer containing calcium sulfate particles of claim 4 , wherein said another resorbable polymer is an aliphatic polyester of alpha-hydroxy acid derivatives.
6. The polymer containing calcium sulfate particles of claim 5 , wherein said aliphatic polyester of alpha-hydroxy acid derivatives is a polylactide.
7. The polymer containing calcium sulfate particles of claim 5 , wherein said aliphatic polyester of alpha-hydroxy acid derivatives is polyglycolide, polydioxanone, or poly ε-caprolactone.
8. The polymer containing calcium sulfate particles of claim 4 , wherein said another resorbable polymer is a poly(desaminotyrosyl-tyrosine alkyl ester carbonate).
9. The polymer containing calcium sulfate particles of claim 8 , wherein said poly(desaminotyrosyl-tyrosine alkyl ester carbonate) is poly(desaminotyrosyl-tyrosine ethyl ester carbonates), poly(desaminotyrosyl-tyrosine butyl ester carbonates), poly(desaminotyrosyl-tyrosine hexyl ester carbonates), or poly(desaminotyrosyl-tyrosine octyl ester carbonates).