Process for preparing recombinant heterocarpine
A process for preparing recombinant heterocarpine with the complete sequence of heterocarpine (SEQ. ID. NO. 10), expression vectors comprising a polynucleotide encoding for heterocarpine, host cells transformed or transfected by said expression vectors as well as a process for obtaining heterocarpine by means of said transformed or transfected host cells are described wherein the recombinant heterocarpine obtained is used to treat cancer.
1 - 5 . (canceled)
6 . An isolated polypeptide comprising the sequence SEQ.ID.NO.14.
7 . An isolated polypeptide according to claim 6 , wherein it is a polypeptide of sequence SEQ.ID.NO.14.
8 - 14 . (canceled)
15 . A pharmaceutical composition comprising, as active ingredient, a polypeptide according to claim 6 and an inert carrier.
16 - 18 . (canceled)
19 . A method of treating a proliferative disease in a warm-blooded animal comprising administrating to a warm-blooded animal in need thereof, an amount of polypeptide of claim 6 sufficient to treat said disease.
20 . A pharmaceutical composition comprising a polypeptide of claim 7 and an inert carrier.
21 . A method of treating a proliferative disease in a warm-blooded animal comprising administrating to a warm-blooded animal in need thereof, an amount of polypeptide of claim 7 sufficient to treat said disease.