IP Library › Granted Patent US 7,910,700
Granted Patent B2
US 7,910,700 · App. 12/317,185 · Granted Mar 22, 2011

Highly thermostable fluorescent proteins

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Quick Facts
Patent No.
US 7,910,700
App. No.
12/317,185
Granted
Mar 22, 2011
Kind
B2
Abstract

Thermostable fluorescent proteins (TSFPs), methods for generating these and other stability-enhanced proteins, polynucleotides encoding such proteins, and assays and method for using the TSFPs and TSFP-encoding nucleic acid molecules are provided. The TSFPs of the invention show extremely enhanced levels of stability and thermotolerance. In one case, for example, a TSFP of the invention is so stable it can be heated to 99° C. for short periods of time without denaturing, and retains 85% of its fluorescence when heated to 80° C. for several minutes. The invention also provides a method for generating stability-enhanced variants of a protein, including but not limited to fluorescent proteins.

Claims (1)

1. A polypeptide having the amino acid sequence of SEQ ID NO: 10.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 6, 2018
From: LOS ALAMOS NATIONAL SECURITY, LLC
To: TRIAD NATIONAL SECURITY, LLC
Reel/Frame 047438/0511 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 30, 2009
From: BRADBURY, ANDREW M.; WALDO, GEOFFREY S.; KISS, CSABA
To: LOS ALAMOS NATIONAL SECURITY, LLC
Reel/Frame 022486/0826 →
CONFIRMATORY LICENSE Recorded Feb 17, 2009
From: LOS ALAMOS NATIONAL SECURITY
To: ENERGY, U.S. DEPARTMENT OF
Reel/Frame 022268/0381 →