IP Library › Granted Patent US 8,073,633

Granted Patent B2

US 8,073,633 · App. 12/319,154 · Granted Dec 6, 2011

Computational methods and systems for suggesting modulators of CYP450 as treatment options

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Quick Facts

Patent No.: US 8,073,633
App. No.: 12/319,154
Granted: Dec 6, 2011
Kind: B2

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Abstract

Computational methods and systems are described which accept input, identify one or more CYP450-family enzymes, identify one or more modulators of the CYP450-family enzymes, and communicate treatments to at least one system user, wherein the treatments include one or more of the identified at least one modulator.

Claims (193)

1. A method comprising:

accepting input that specifies an individual;

accepting input that identifies a drug therapy associated with the individual;

identifying at least one first CYP450-family enzyme that influences metabolism of the drug therapy associated with the individual;

identifying at least one second CYP450-family enzyme that influences metabolism of the drug therapy associated with the individual;

identifying at least one modulator of one or more of the at least one first CYP450-family enzyme;

identifying at least one modulator of one or more of the at least one second CYP450-family enzyme; and

invoking circuitry for communicating one or more treatment to a system user, wherein the treatment includes one or more of the identified at least one modulator of one or more of the at least one first CYP450-family enzyme and one or more of the identified at least one modulator of one or more of the at least one second CYP450-family enzyme.

2. The method of claim 1 , comprising:

suggesting one or more dosages of the one or more treatment to a system user;

identifying at least one environmental factor associated with an alteration in activity of at least one of the one or more treatment; and

communicating one or more alternate dosages of the one or more treatment to a system user, wherein the one or more alternate dosages are calculated to compensate for the alteration in activity of at least one of the one or more treatment.

3. The method of claim 1 , comprising:

suggesting one or more dosages of the one or more treatment to a system user;

identifying at least one dietary factor associated with an alteration in activity of at least one of the one or more treatment; and

4. The method of claim 1 , comprising:

suggesting one or more dosage schedules of the one or more treatment to a system user;

identifying at least one environmental factor associated with an alteration in activity of at least one of the one or more treatment; and

communicating one or more alternate dosage schedules of the one or more treatment to a system user, wherein the one or more alternate dosage schedules are calculated to compensate for the alteration in activity of at least one of the one or more treatment.

5. The method of claim 1 , comprising:

suggesting one or more dosage schedules of the one or more treatment to a system user;

identifying at least one dietary factor associated with an alteration in activity of at least one of the one or more treatment; and

6. The method of claim 1 , comprising:

accepting input specifying one or more variant of at least one CYP450-family enzyme that influences metabolism of the drug therapy associated with the individual;

identifying at least one modulator of at least one of the one or more variant of at least one CYP450-family enzyme; and

communicating one or more treatment to a system user, wherein the treatment includes the identified at least one modulator of at least one of the one or more variant of at least one CYP450-family enzyme.

7. The method of claim 1 , comprising:

accepting input specifying one or more variant of at least one CYP450-family gene that influences metabolism of the drug therapy associated with the individual;

identifying at least one modulator of at least one of the one or more variant of at least one CYP450-family gene; and

8. The method of claim 1 , comprising:

accepting input specifying one or more variant of the at least one first CYP450-family enzyme that influences metabolism of the drug therapy associated with the individual;

accepting input specifying one or more variant of the at least one second CYP450-family enzyme that influences metabolism of the drug therapy associated with the individual;

identifying at least one modulator of the one or more variant of the at least one first CYP450-family enzyme;

identifying at least one modulator of the one or more variant of the at least one second CYP450-family enzyme; and

communicating one or more treatment to a system user, wherein the treatment includes the identified at least one modulator of the one or more variant of the at least one first CYP450-family enzyme and the identified at least one modulator of the one or more variant of the at least one second CYP450-family enzyme.

9. The method of claim 1 , comprising:

identifying at least one environmental factor associated with activity of at least one CYP450-family enzyme that influences metabolism of the drug therapy associated with the individual; and

communicating at least one environmental mitigation strategy to a system user.

10. The method of claim 1 , comprising:

identifying at least one dietary factor associated with activity of at least one CYP450-family enzyme that influences metabolism of the drug therapy associated with the individual; and

communicating at least one dietary mitigation strategy to a system user.

11. The method of claim 1 , comprising:

associating at least one anatomic location with predicted activity of the at least one first CYP450-family enzyme;

associating the at least one anatomic location with one or more of the at least one modulator of the at least one first CYP450-family enzyme; and

communicating one or more treatment to a system user, wherein the treatment includes one or more of the at least one modulator of the at least one first CYP450-family enzyme associated with the at least one anatomic location.

12. A system, comprising:

circuitry for accepting input that specifies an individual;

circuitry for accepting input that identifies a drug therapy associated with the individual;

circuitry for identifying at least one first CYP450-family enzyme that influences metabolism of the drug therapy associated with the individual;

circuitry for identifying at least one second CYP450-family enzyme that influences metabolism of the drug therapy associated with the individual;

circuitry for identifying at least one modulator of one or more of the at least one first CYP450-family enzyme;

circuitry for identifying at least one modulator of one or more of the at least one second CYP450-family enzyme; and

circuitry for communicating one or more treatment to a system user, wherein the treatment includes one or more of the identified at least one modulator of one or more of the at least one first CYP450-family enzyme and one or more of the identified at least one modulator of one or more of the at least one second CYP450-family enzyme.

13. The system of claim 12 , comprising:

circuitry for suggesting one or more dosages of the one or more treatment to a system user;

circuitry for identifying at least one environmental factor associated with an alteration in activity of at least one of the one or more treatment; and

circuitry for communicating one or more alternate dosages of the one or more treatment to a system user, wherein the one or more alternate dosages are calculated to compensate for the alteration in activity of at least one of the one or more treatment.

14. The system of claim 12 , comprising:

circuitry for suggesting one or more dosages of the one or more treatment to a system user;

circuitry for identifying at least one dietary factor associated with an alteration in activity of at least one of the one or more treatment; and

15. The system of claim 12 , comprising:

circuitry for suggesting one or more dosage schedules of the one or more treatment to a system user;

circuitry for identifying at least one environmental factor associated with an alteration in activity of at least one of the one or more treatment; and

circuitry for communicating one or more alternate dosage schedules of the one or more treatment to a system user, wherein the one or more alternate dosage schedules are calculated to compensate for the alteration in activity of at least one of the one or more treatment.

16. The system of claim 12 , comprising:

circuitry for suggesting one or more dosage schedules of the one or more treatment to a system user;

circuitry for identifying at least one dietary factor associated with an alteration in activity of at least one of the one or more treatment; and

17. The system of claim 12 , comprising:

circuitry for accepting input specifying one or more variant of at least one CYP450-family enzyme that influences metabolism of the drug therapy associated with the individual;

circuitry for identifying at least one modulator of at least one of the one or more variant; and

circuitry for communicating one or more treatment to a system user, wherein the treatment includes the identified at least one modulator of at least one of the one or more variant.

18. The system of claim 12 , comprising:

circuitry for accepting input specifying one or more variant of at least one CYP450-family gene that influences metabolism of the drug therapy associated with the individual;

circuitry for identifying at least one modulator of at least one of the one or more variant of at least one CYP450-family gene; and

circuitry for communicating one or more treatment to a system user, wherein the treatment includes the identified at least one modulator of at least one of the one or more variant of at least one CYP450-family gene.

19. The system of claim 12 , comprising:

circuitry for accepting input specifying one or more variant of the at least one first CYP450-family enzyme that influences metabolism of the drug therapy associated with the individual;

circuitry for accepting input specifying one or more variant of the at least one second CYP450-family enzyme that influences metabolism of the drug therapy associated with the individual;

circuitry for identifying at least one modulator of the one or more variant of the at least one first CYP450-family enzyme;

circuitry for identifying at least one modulator of the one or more variant of the at least one second CYP450-family enzyme; and

circuitry for communicating one or more treatment to a system user, wherein the treatment includes the identified at least one modulator of the one or more variant of the at least one first CYP450-family enzyme and the identified at least one modulator of the one or more variant of the at least one second CYP450-family enzyme.

20. The system of claim 12 , comprising:

circuitry for identifying at least one environmental factor associated with activity of at least one CYP450-family enzyme that influences metabolism of the drug therapy associated with the individual; and

circuitry for communicating at least one environmental mitigation strategy to a system user.

21. The system of claim 12 , comprising:

circuitry for identifying at least one dietary factor associated with activity of at least one CYP450-family enzyme that influences metabolism of the drug therapy associated with the individual; and

circuitry for communicating at least one environmental mitigation strategy to a system user.

22. The system of claim 12 , comprising:

circuitry for associating at least one anatomic location with predicted activity of the at least one first CYP450-family enzyme;

circuitry for associating the at least one anatomic location with one or more of the at least one modulator of the at least one first CYP450-family enzyme; and

circuitry for communicating one or more treatment to a system user, wherein the treatment includes the at least one modulator of the at least one first CYP450-family enzyme associated with the at least one anatomic location.

23. A method comprising:

accepting input that specifies an individual;

accepting input that identifies a first drug therapy associated with the individual;

accepting input that identifies a second drug therapy associated with the individual;

identifying at least one CYP450-family enzyme that influences metabolism of both the first drug therapy and the second drug therapy;

identifying at least one modulator of one or more of the at least one CYP450-family enzyme; and

invoking circuitry for communicating one or more treatment to a system user, wherein the one or more treatment includes one or more of the identified at least one modulator.

24. The method of claim 23 , comprising:

accepting input specifying one or more variant of at least one CYP450-family enzyme associated with the individual;

identifying at least one modulator of the one or more variant; and

communicating one or more treatment to a system user, wherein the one or more treatment includes one or more of the identified at least one modulator of the one or more variant.

25. The method of claim 23 , comprising:

accepting input specifying one or more variant of at least one CYP450-family gene associated with the individual;

identifying at least one modulator of the one or more variant of at least one CYP450-family gene; and

communicating one or more treatment to a system user, wherein the one or more treatment includes one or more of the identified at least one modulator of the one or more variant of at least one CYP450-family gene.

26. The method of claim 23 , comprising:

accepting input specifying one or more variant of the at least one first CYP450-family enzyme associated with the individual;

accepting input specifying one or more variant of the at least one second CYP450-family enzyme associated with the individual;

identifying at least one modulator of the one or more variant of the at least one first CYP450-family enzyme;

identifying at least one modulator of the one or more variant of the at least one second CYP450-family enzyme; and

27. The method of claim 23 , comprising:

suggesting one or more dosages of the one or more treatment to a system user;

identifying at least one environmental factor associated with an alteration in activity of at least one of the one or more treatment; and

communicating one or more alternate dosages of the one or more treatment, wherein the one or more alternate dosages are calculated to compensate for the alteration in activity of at least one of the one or more treatment.

28. The method of claim 23 , comprising:

suggesting one or more dosages of the one or more treatment to a system user;

identifying at least one dietary factor associated with an alteration in activity of at least one of the one or more treatment; and

29. The method of claim 23 , comprising:

identifying at least one dietary factor associated with activity of the at least one CYP450-family enzyme; and

communicating at least one dietary mitigation strategy to a system user.

30. The method of claim 23 , comprising:

identifying at least one environmental factor associated with activity of the at least one CYP450-family enzyme;

requesting information regarding one or more of the at least one environmental factor in relation to the individual; and

communicating at least one environmental mitigation strategy to a system user.

31. The method of claim 23 , comprising:

associating at least one anatomic location with predicted activity of the at least one CYP450-family enzyme;

associating the at least one anatomic location with one or more of the at least one modulator; and

invoking circuitry for communicating at least one treatment to a system user, wherein the treatment includes the at least one modulator of the at least one CYP450-family enzyme associated with the at least one anatomic location.

32. A system comprising:

circuitry for accepting input that specifies an individual;

circuitry for accepting input that identifies a first drug therapy associated with the individual;

circuitry for accepting input that identifies a second drug therapy associated with the individual;

circuitry for identifying at least one CYP450-family enzyme that influences metabolism of both the first drug therapy and the second drug therapy;

circuitry for identifying at least one modulator of one or more of the at least one CYP450-family enzyme; and

circuitry for communicating one or more treatment to a system user, wherein the one or more treatment includes one or more of the at least one modulator.

33. The system of claim 32 , comprising:

circuitry for accepting input specifying one or more variant of at least one CYP450-family enzyme associated with the individual;

circuitry for identifying at least one modulator of the one or more variant; and

circuitry for communicating one or more treatment to a system user, wherein the one or more treatment includes one or more of the identified at least one modulator of the one or more variant.

34. The system of claim 32 , comprising:

circuitry for accepting input specifying one or more variant of at least one CYP450-family gene associated with the individual;

circuitry for identifying at least one modulator of the one or more variant of at least one CYP450-family gene; and

circuitry for communicating one or more treatment to a system user, wherein the one or more treatment includes one or more of the identified at least one modulator of the one or more variant of at least one CYP450-family gene.

35. The system of claim 32 , comprising:

circuitry for accepting input specifying one or more variant of the at least one first CYP450-family enzyme associated with the individual;

circuitry for accepting input specifying one or more variant of the at least one second CYP450-family enzyme associated with the individual;

circuitry for identifying at least one modulator of the one or more variant of the at least one first CYP450-family enzyme;

circuitry for identifying at least one modulator of the one or more variant of the at least one second CYP450-family enzyme; and

36. The system of claim 32 , comprising:

circuitry for suggesting one or more dosages of the one or more treatment to a system user;

circuitry for identifying at least one environmental factor associated with an alteration in activity of at least one of the one or more treatment; and

circuitry for communicating one or more alternate dosages of the one or more treatment, wherein the one or more alternate dosages are calculated to compensate for the alteration in activity of at least one of the one or more treatment.

37. The system of claim 32 , comprising:

circuitry for suggesting one or more dosages of the one or more treatment to a system user;

circuitry for identifying at least one dietary factor associated with an alteration in activity of at least one of the one or more treatment; and

38. The system of claim 32 , comprising:

circuitry for identifying at least one dietary factor associated with activity of the at least one CYP450-family enzyme; and

circuitry for communicating at least one dietary mitigation strategy to a system user.

39. The system of claim 32 , comprising:

circuitry for identifying at least one environmental factor associated with activity of the at least one CYP450-family enzyme;

circuitry for requesting information regarding one or more of the at least one environmental factor in relation to the individual; and

circuitry for communicating at least one environmental mitigation strategy to a system user.

40. The system of claim 32 , comprising:

circuitry for associating at least one anatomic location with predicted activity of the at least one CYP450-family enzyme;

circuitry for associating the at least one anatomic location with one or more of the at least one modulator; and

circuitry for communicating at least one treatment to a system user, wherein the treatment includes the at least one modulator of the at least one CYP450-family enzyme associated with the at least one anatomic location.

41. A system, comprising:

at least one computer program for use with at least one computer system and wherein the computer program includes a plurality of instructions including but not limited to:

one or more instructions for accepting input that specifies an individual;

one or more instructions for accepting input that identifies a drug therapy associated with the individual;

one or more instructions for identifying at least one first CYP450-family enzyme that influences metabolism of the drug therapy associated with the individual;

one or more instructions for identifying at least one second CYP450-family enzyme that influences metabolism of the drug therapy associated with the individual;

one or more instructions for identifying at least one modulator of one or more of the at least one first CYP450-family enzyme;

one or more instructions for identifying at least one modulator of one or more of the at least one second CYP450-family enzyme; and

one or more instructions for communicating one or more treatment to a system user, wherein the treatment includes one or more of the identified at least one modulator of one or more of the at least one first CYP450-family enzyme and one or more of the identified at least one modulator of one or more of the at least one second CYP450-family enzyme.

42. A system comprising:

at least one computer program for use with at least one computer system and wherein the computer program includes a plurality of instructions including but not limited to:

one or more instructions for accepting input that specifies an individual;

one or more instructions for accepting input that identifies a first drug therapy associated with the individual;

one or more instructions for accepting input that identifies a second drug therapy associated with the individual;

one or more instructions for identifying at least one CYP450-family enzyme that influences metabolism of both the first drug therapy and the second drug therapy;

one or more instructions for identifying at least one modulator of one or more of the at least one CYP450-family enzyme; and

one or more instructions for communicating one or more treatment to a system user, wherein the one or more treatment includes one or more of the at least one modulator.

Assignments (3)

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 30, 2023

From: DEEP SCIENCE LLC

To: ENTERPRISE SCIENCE FUND, LLC

Reel/Frame 064785/0001 →

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 1, 2011

From: SEARETE LLC

To: THE INVENTION SCIENCE FUND I, LLC

Reel/Frame 027155/0644 →

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 30, 2009

From: BANGERA, MAHALAXMI GITA; HYDE, RODERICK A.; SWEENEY, ELIZABETH A.; WOOD, LOWELL L., JR.

To: SEARETE LLC

Reel/Frame 022707/0347 →