Flowable pharmaceutical depot
Flowable pharmaceutical depots are described. The flowable pharmaceutical depot includes a polyester, such as a polylactic acid or a poly(trimethylene carbonate) endcapped with a primary alcohol and a pain relieving therapeutic agent, such as a post operative pain relieving therapeutic agent. Method of making and using the same are also described.
1. A method comprising:
depolymerizing a polyester polymer with a primary alcohol to form an endcapped polyester polymer, wherein the primary alcohol comprises dodecanol and the polyester polymer comprises polylactic acid and the polylactic acid to dodecanol ratio is 2.68;
adding 4-dimethylaminopyridine to the polylactic acid and the dodecanol, where the polylactic acid polymer to 4-dimethylaminopyridine ratio is 1.64; and
combining the endcapped polyester polymer with a pain relieving therapeutic agent, forming a flowable pharmaceutical depot, wherein the pain relieving therapeutic agent comprises clonidine from 11 to about 20% by weight and where the flowable pharmaceutical depot does not cure or cross-link once administered in vivo.
2. A method according to claim 1 , wherein the flowable pharmaceutical depot has a viscosity in a range from 0.1 to 500 Pa·s.
3. A method according to claim 1 , wherein the pain relieving therapeutic agent further comprises bupivacaine.
4. A method according to claim 1 , further comprising blending a first polyester polymer endcapped with a primary alcohol having a first molecular weight in a range from 500 to 3000 g/mol with a second polyester polymer endcapped with a primary alcohol having a second molecular weight in a range from 500 to 3000 g/mol, wherein the first molecular weight is different than the second molecular weight.