Combination therapies using melengestrol acetate and zilpaterol or its salts
This invention generally relates to a method for promoting growth and increasing feed utilization efficiency in animals, and, more specifically, to combinations comprising zilpaterol (and salts thereof) and melengestrol acetate. Included within this invention are treatment methods comprising the administration of such combinations to animals, compositions comprising such combinations, uses of such combinations to prepare medicaments, and kits for using such combinations.
1. A method for improving feed utilization efficiency or increasing the rate of weight gain in an animal, wherein the method comprises administering to the animal an effective amount of zilpaterol (or a salt thereof), an effective amount of melengestrol acetate, an effective amount of monensin (or a salt thereof) and an effective amount of tylosin (or a salt thereof).
2. The method of claim 1 , wherein the amount of the zilpaterol (or salt thereof) and the amount of melengestrol acetate are, when combined, sufficient to improve the animal's average daily feed utilization efficiency over a period of at least about 3 days relative to the average daily feed utilization efficiency that would be realized by administering the amount of the zilpaterol (or salt thereof) without any melengestrol acetate over the same amount of time under otherwise substantially identical feeding conditions.
3. The method of claim 2 , wherein the amount of the zilpaterol (or salt thereof) and the amount of melengestrol acetate are, when combined, sufficient to increase the animal's average daily weight gain over a period of at least about 3 days by at least about 100% the average daily weight gain that is realized during the week immediately before administration of the zilpaterol (or salt thereof) and melengestrol acetate under otherwise substantially identical feeding conditions.
4. The method of claim 1 , wherein the amount of the zilpaterol (or salt thereof) and the amount of melengestrol acetate are, when combined, sufficient to increase the animal's average daily weight gain over a period of at least about 3 days relative to the average daily weight gain that would be realized by administering the amount of the zilpaterol (or salt thereof) without any melengestrol acetate over the same amount of time under otherwise substantially identical feeding conditions.
5. The method of claim 4 , wherein the amount of the zilpaterol (or salt thereof) and the amount of melengestrol acetate are, when combined, sufficient to increase the animal's average daily weight gain over a period of at least about 3 days by at least about 1.2 times the average daily weight gain that would be realized by administering the amount of the zilpaterol (or salt thereof) without any melengestrol acetate over the same amount of time under otherwise substantially identical feeding conditions.
6. The method of claim 1 , wherein at least a portion of the zilpaterol (or salt thereof) and at least a portion of the melengestrol acetate are administered in a single formulation.
7. The method of claim 1 , wherein at least a portion of the zilpaterol (or salt thereof) is administered in a separate formulation from at least a portion of the melengestrol acetate.
8. The method of claim 1 , wherein at least a portion of the zilpaterol (or salt thereof) or at least a portion of the melengestrol acetate is administered orally.
9. The method of claim 1 , wherein the zilpaterol (or salt thereof) and the melengestrol acetate are administered orally.
10. The method of claim 1 , wherein the method comprises administering zilpaterol hydrochloride.
11. The method of claim 1 , wherein the method further comprises administering at least one additional steroid.
12. The method of claim 1 , wherein the method further comprises administering trenbolone acetate.
13. The method of claim 1 , wherein the method further comprises administering zeranol, estradiol, or estradiol benzoate.
14. The method of claim 1 , wherein the method further comprises administering at least one ionophore.
15. The method of claim 1 , wherein the method comprises administering monensin sodium.
16. The method of claim 1 , wherein the method further comprises administering at least one antibiotic.
17. The method of claim 1 , wherein the method comprises administering tylosin phosphate or tylosin tartrate.
18. The method of claim 1 , wherein the animal is a bovine animal.
19. The method of claim 1 , wherein the animal is a swine animal.
20. The method of claim 1 , wherein the animal is a bird.
21. The method of claim 1 , wherein the animal is a fish.