Tricalcium phosphate coarse particle compositions and methods for making the same
View Patent ↗Methods for preparing a tricalcium phosphate coarse particle composition are provided. Aspects of the methods include converting an initial tricalcium phosphate particulate composition to hydroxyapatite, sintering the resultant hydroxyapatite to produce a second tricalcium phosphate composition and then mechanically manipulating the second tricalcium phosphate composition to produce a tricalcium phosphate coarse particle composition. The subject methods and compositions produced thereby find use in a variety of applications.
1. A method of making a tricalcium phosphate coarse particle composition, said method comprising:
(a) converting an initial tricalcium phosphate particulate composition to hydroxyapatite;
(b) sintering said hydroxyapatite to produce a second tricalcium phosphate composition; and
(c) mechanically manipulating said second tricalcium phosphate composition to produce a tricalcium phosphate coarse particle composition, wherein said coarse particles comprise sodium in an amount ranging from 1500 to 2500 ppm.
2. The method according to claim 1 , wherein said initial tricalcium phosphate particulate composition is converted to hydroxyapatite by combining said initial tricalcium phosphate particulate composition with an alkali metal phosphate solution.
3. The method according to claim 2 , wherein said alkali metal phosphate solution is a sodium phosphate solution.
4. The method according to claim 1 , wherein after step (a), said hydroxyapatite is milled before sintering in step (b).
5. The method according to claim 1 , wherein after step (a), said hydroxyapatite is pelletized before sintering in step (b).
6. The method according to claim 1 , wherein said initial tricalcium phosphate particulate composition is prepared by:
(a) combining dicalcium phosphate anhydrous, calcite and water to produce a paste composition;
(b) sintering said paste composition to produce a sintered product; and
(c) mechanically disrupting said sintered product to produce said initial tricalcium phosphate particulate composition.
7. The method according to claim 1 , wherein said tricalcium phosphate coarse particle composition comprises a-tricalcium phosphate particles.
8. The method according to claim 1 , wherein said method yields a composition that is 25% or more coarse particles.
9. The method according to claim 1 , wherein said method yields a composition that is 50% or more coarse particles.
10. The method according to claim 1 , wherein said method yields a composition that is 60% or more coarse particles.
11. The method according to claim 1 , wherein said method yields a composition that is 80% or more coarse particles.
12. The method according to claim 1 , wherein said tricalcium phosphate coarse particle composition comprises particles ranging in size from 38 to 212 μm.
13. A tricalcium phosphate coarse particle composition produced according to the method of claim 1 .
14. A tricalcium phosphate coarse particle composition comprising tricalcium phosphate particles ranging in size from 38 to 212 μm, wherein said particles comprise sodium in an amount ranging from 1500 to 2500 ppm.
15. The method according to claim 1 , wherein said sintering comprises heating said hydroxyapatite to temperature ranging from 1300 to 1500° C.
16. The method according to claim 1 , wherein said tricalcium phosphate coarse particle composition comprises particles that are 95-97% α-TCP.
17. The method according to claim 1 , wherein said method further comprises combining said tricalcium phosphate coarse particle composition with a fine calcium phosphate particulate composition to produce a dry reactant cement component.
18. The method according to claim 17 , wherein said fine calcium phosphate particulate composition has a mean particle size of less than 8 μm and narrow particle size distribution.
19. The method according to claim 17 , wherein the ratio of the mass of the fine particle composition to the total mass of the tricalcium phosphate coarse particle composition ranges from 1 to 10.