SURFACE MODIFIED BIOMEDICAL DEVICES
A surface modified biomedical device is provided comprising a biomedical device having a coating on at least a portion thereof, the coating comprising one or more hydrophilic polymers having one or more non-ethylenically-unsaturated carboxylic acid terminated groups.
1 . A method for improving the wettability of a biomedical device, the method comprising the step of contacting a surface of the biomedical device with a composition comprising one or more hydrophilic polymers having one or more non-ethylenically-unsaturated carboxylic acid terminated groups.
2 . The method of claim 1 , wherein the biomedical device is a contact lens.
3 . The method of claim 1 , wherein the biomedical device is a silicone hydrogel contact lens.
4 . The method of claim 1 , wherein the hydrophilic polymer comprises one or more units derived from N-vinylpyrrolidone.
5 . The method of claim 1 , wherein the hydrophilic polymer comprises one or more units derived from N-vinylpyrrolidone, alkylene oxides, glyceryl methacrylate, glyceryl acrylate, dimethyl methacrylamide, dimethyl acrylamide, 2-hydroxyethyl methacrylate, 2-hydroxyethyl acrylate, erythritol methacrylate, erythritol acrylate, xylitol methacrylate, xylitol acrylate, sorbitol methacrylate, sorbitol acrylate, derivatives thereof or mixtures thereof.
6 . The method of claim 1 , wherein the hydrophilic polymer is a reaction product of a hydroxyl-terminated oligomer or polymer having a plurality of hydrophilic groups with a saturated, cyclic anhydride.
7 . The method of claim 5 , wherein the hydroxyl-terminated oligomer or polymer comprises one or more units derived from N-vinylpyrrolidone.
8 . The method of claim 5 , wherein the saturated, cyclic anhydride is selected from the group consisting of succinic anhydride, glutaric anhydride and adipic anhydride.
9 . The method of claim 1 , wherein the hydrophilic polymer has one non-ethylenically-unsaturated carboxylic acid terminated group.
10 . The method of claim 1 , wherein the hydrophilic polymer is terminated on each end with a non-ethylenically-unsaturated carboxylic acid terminal group.
11 . A surface modified biomedical device comprising a biomedical device having a coating on a surface thereof, the coating comprising one or more hydrophilic polymers having one or more non-ethylenically-unsaturated carboxylic acid terminated groups.
12 . The surface modified biomedical device of claim 11 , wherein the biomedical device is a contact lens.
13 . The surface modified biomedical device of claim 11 , wherein the biomedical device is a silicone hydrogel contact lens.
14 . The surface modified biomedical device of claim 11 , wherein the hydrophilic polymer comprises one or more units derived from N-vinylpyrrolidone.
15 . The surface modified biomedical device of claim 11 , wherein the hydrophilic polymer comprises one or more units derived from N-vinylpyrrolidone, alkylene oxides, glyceryl methacrylate, glyceryl acrylate, dimethyl methacrylamide, dimethyl acrylamide, 2-hydroxyethyl methacrylate, 2-hydroxyethyl acrylate, erythritol methacrylate, erythritol acrylate, xylitol methacrylate, xylitol acrylate, sorbitol methacrylate, sorbitol acrylate, derivatives thereof or mixtures thereof.
16 . The surface modified biomedical device of claim 11 , wherein the hydrophilic polymer is a reaction product of a hydroxyl-terminated oligomer or polymer having a plurality of hydrophilic groups with a saturated, cyclic anhydride.
17 . The surface modified biomedical device of claim 16 , wherein the hydroxyl-terminated oligomer or polymer comprises one or more units of N-vinylpyrrolidone.
18 . The surface modified biomedical device of claim 16 , wherein the saturated, cyclic anhydride is selected from the group consisting of succinic anhydride, glutaric anhydride and adipic anhydride.
19 . The surface modified biomedical device of claim 11 , wherein the hydrophilic polymer has one non-ethylenically-unsaturated carboxylic acid terminated group.
20 . The surface modified biomedical device of claim 11 , wherein the hydrophilic polymer is terminated on each end with a non-ethylenically-unsaturated carboxylic acid terminal group.
21 . A method of forming a surface modified biomedical device, the method comprising contacting a surface of a biomedical device with a composition comprising one or more hydrophilic polymers having one or more non-ethylenically-unsaturated carboxylic acid terminated groups.
22 . The method of claim 21 , wherein the biomedical device is a contact lens.
23 . The method of claim 21 , wherein the hydrophilic polymer comprises one or more units derived from N-vinylpyrrolidone.
24 . The method of claim 21 , wherein the hydrophilic polymer comprises one or more derived from N-vinylpyrrolidone, alkylene oxides, glyceryl methacrylate, glyceryl acrylate, dimethyl methacrylamide, dimethyl acrylamide, 2-hydroxyethyl methacrylate, 2-hydroxyethyl acrylate, erythritol methacrylate, erythritol acrylate, xylitol methacrylate, xylitol acrylate, sorbitol methacrylate, sorbitol acrylate, derivatives thereof or mixtures thereof.
25 . The method of claim 21 , wherein the hydrophilic polymer is a reaction product of a hydroxyl-terminated oligomer or polymer having a plurality of hydrophilic groups with a saturated, cyclic anhydride.