Treatment for Organ Regeneration with Combination of Drug and Biologics
Combination therapies of drugs and biologics for treatment of acute and chronic organ degeneration are disclosed. More specifically, the use of morphogens, stem cells, and anti-inflammatories or inhibitors for the renin-angiotensin-aldosterone system (RAAS) for the treatment of acute and chronic renal disease is disclosed.
1 . A method of treating conditions which place mammals at a risk of acute or chronic renal failure, the method comprising administering a combination of at least one morphogen, stem cells and an anti-inflammatory or an inhibitor of the renin-angiotensin-aldosterone system.
2 . The method of claim 1 wherein said morphogen is rhGDF-5.
3 . The method of claim 2 wherein said rhGDF-5 is administered intravenously, intraperitoneal or by renal artery or subcapsular injection, or locally by implantation in matrices.
4 . The method of claim 1 wherein said stem cells are bone marrow mesenchymal.
5 . The method of claim 1 wherein said stem cells are adult stem cells from any tissue.
6 . The method of claim 1 wherein said stem cells are from any developmental stage.
7 . The method of claim 1 wherein said stem cells are renal cells induced with morphogens.
8 . The method of claim 1 wherein said inhibitors of RAAS is ACE inhibitors,
9 . The method of claim 1 wherein said inhibitors of RAAS is rennin inhibitors.
10 . The method of claim 1 wherein said inhibitors of RAAS is aldosterone receptor antagonists.
11 . The method of claim 1 wherein said anti-inflammatories are from the 38 MAP kinase inhibitors.
12 . The method of claim 1 wherein said anti-inflammatories are antibodies against pro-inflammatory cytokines.
13 . The method of claim 1 wherein said anti-inflammatories are antibodies against chemoattractant molecules.
14 . The method of claim 1 wherein said anti-inflammatories are cell cycle inhibitors.