Coating solutions comprising segmented interactive block copolymers

1. A method of forming a surface modified medical device, the method comprising:

providing a medical device having at least one group providing interactive functionality on at least one surface of the medical device, wherein the medical device comprises hydrogel materials;

providing a surface modifying agent

comprising an interactive segmented block copolymer having a structure selected from the following structural formulas I-III:

R1-[(A) m]p -[(B) n]q -X  (I),

R1-[(A) m]p -[(B) n]q -R2, and  (II)

R1-[(B) n]q -[(A) m]p -R2-[(A) m]p -[(B) n]q -R1  (III)

wherein R1 is a reactive residue of a moiety capable of acting as an initiator for Atom Transfer Radical Polymerization, a radical forming residue of a Reversible addition-fragmentation chain transfer polymerization agent or a free radical initiator; R2 is a thio carbonyl thio group, thio carbonyl fragment of a chain transfer agent or a derivatized reaction product; A is a chemical binding unit block, B is a hydrophilic unit block, m is 1 to 10,000, n is 1 to 10,000, p and q are natural numbers, and X is a halogen capping group of an initiator for Atom Transfer Radical Polymerization or a derivatized reaction product

contacting the at least one surface having interactive functionality of the medical device with the surface modifying agent, and;

subjecting the device surface and surface modifying agent to reaction conditions suitable for forming a chemical interaction selected from the group consisting of electrostatic or complexation interaction between the device surface and the surface modifying agent to form a surface modified medical device.

2. The method of claim 1 wherein the medical device is prepared from a silicon containing monomer.

3. The method of claim 2 wherein the silicon containing monomer comprises a silicon containing monomer selected from the group consisting of silicon containing vinyl carbonates, silicon containing vinyl carbamates, polyurethane-polysiloxanes having one or more hard-soft-hard blocks and end-capped with a hydrophilic monomer, fumarate containing silicon containing monomers, poly(organosiloxanes) capped with an unsaturated group at two or more ends of the molecule, polyurethane-polysiloxane macromonomers and mixtures thereof.

4. The method of claim 2 wherein the medical device comprises as a bulk monomer mixture to be copolymerized 5 to 50 percent by weight of one or more silicon containing macromonomers, 5 to 75 percent by weight of one or more polysiloxanylalkyl (meth)acrylic monomers, and 10 to 50 percent by weight of a hydrophilic monomer.

5. The method of claim 2 wherein the medical device comprises as a bulk monomer mixture to be copolymerized 10 to 25 percent by weight of one or more silicon containing macromonomers, 30 to 60 percent by weight of one or more polysiloxanylalkyl(meth)acrylic monomers, and 20 to 40 percent by weight of a hydrophilic monomer.

6. The method of claim 1 wherein the medical device comprises vinyl functionalized polydimethylsiloxanes copolymerized with hydrophilic monomers.

7. The method of claim 1 wherein the medical device comprises fluorinated monomers.

8. The method of claim 1 wherein the medical device comprises methacrylate functionalized fluorinated polyethylene oxides copolymerized with hydrophilic monomers.

9. The method of claim 1 wherein the medical device is selected from the group consisting of heart valves, intraocular lenses, intraocular lens inserters, contact lenses, intrauterine devices, vessel substitutes, artificial ureters, vascular stents, phakic intraocular lenses, aphakic intraocular lenses, corneal implants, catheters, implants, and artificial breast tissue.

10. The method of claim 9 wherein the medical device formed is a soft contact lens.

11. The method of claim 10 wherein the medical device is a silicon containing hydrogel contact lens material.

12. The method of claim 1 , wherein the interactive segmented block copolymer has the chemical binding unit is a monomer selected from the group consisting of styrene boronic acid, 3-methacrylamido styrene boronic acid, 2-methacryloyloxyethylsulfonate salts, 3-methacrylamidopropyl-N,N,N-trimethyammonium salts, 2-methacryloyloxyethyl-N,N,N-trimethylammonium salts, and amine-containing monomers, such as 3-methacrylamidopropyl-N,N-dimethyl amine.

13. The method of claim 1 , wherein the interactive segmented block copolymer has a hydrophilic unit monomer selected from the group consisting of 2-hydroxyethyl methacrylate, glycerol methacrylate, methacrylic acid, acrylic acid, methacrylamide, acrylamide, N,N′-dimethylmethacrylamide, N,N′-dimethylacrylamide; ethylenically unsaturated poly(alkylene oxide)s, cyclic lactams, N-vinyl-2-pyrrolidone, vinyl carbonate, vinyl carbamate, 2-hydroxyethyl acrylate, 2-(2-ethoxyethoxy)ethyl(meth)acrylate, glyceryl(meth)acrylate, poly(ethylene glycol (meth)acrylate), tetrahydrofurfuryl(meth)acrylate, N-vinyl acetamide and copolymers, derivatives and combinations thereof.

14. The method of claim 1 , wherein the interactive segmented block copolymer has a chemical binding unit comprises between 1 and about 1,000 units.

15. The method of claim 1 , wherein the interactive segmented block copolymer has a chemical binding unit comprises between 1 and about 100 units.

16. The method of claim 1 , wherein the interactive segmented block copolymer has a chemical binding unit comprising between 1 and about 30 units.

17. The method of claim 1 , wherein the interactive segmented block copolymer has a hydrophilic block comprising between 1 and about 10,000 units.

18. The method of claim 1 , wherein the interactive segmented block copolymer has a hydrophilic block comprising between about 10 and about 1,000 units.

19. The method of claim 1 , wherein the interactive segmented block copolymer has a hydrophilic block comprising between about 20 and about 300 units.