Antimicrobial peptides and methods of identifying the same
View Patent ↗Antimicrobial peptides and methods of identifying the same are provided.
1. An isolated LL-37 peptide having antimicrobial activity and having from 13 to 21 amino acids, wherein the amino acid sequence from positions 1 to 13 of said LL-37 peptide has at least 80% identity with SEQ ID NO: 5, and wherein at least one of the amino acids at positions 4, 8, and 12 is a D-amino acid.
2. The isolated LL-37 peptide of claim 1 , wherein the amino acid sequence from positions 1 to 13 of said LL-37 peptide has at least 90% identity with SEQ ID NO: 5.
3. The isolated LL-37 peptide of claim 1 , wherein said LL-37 peptide has 13 to 18 amino acids.
4. The isolated LL-37 peptide of claim 1 , wherein said LL-37 peptide has at least 80% identity with SEQ ID NO: 4.
5. A pharmaceutical composition comprising at least one LL-37 peptide of claim 1 and at least one pharmaceutically acceptable carrier.
6. A method for treating a bacterial infection in a patient comprising administering the pharmaceutical composition of claim 5 to a patient in need thereof.
7. The isolated LL-37 peptide of claim 1 , wherein said peptide comprises D-amino acids spaced by three consecutive L-amino acids.
8. The isolated LL-37 peptide of claim 1 , wherein the amino acids at positions 4, 8, and 12 are D-amino acids.
9. The isolated LL-37 peptide of claim 1 , wherein said peptide is amidated.
10. The isolated LL-37 peptide of claim 1 , wherein said peptide is acetylated.