IP Library Granted Patent US 8,174,763
Granted Patent B2
US 8,174,763 · App. 12/335,390 · Granted May 8, 2012

Methods and systems for controlably scanning a cytological specimen

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Quick Facts
Patent No.
US 8,174,763
App. No.
12/335,390
Granted
May 8, 2012
Kind
B2
Abstract

Methods and systems for scanning a cytological specimen carried by a slide. Movement or positioning of a motorized stage of an automated screening system may be controlled manually by a user such that the user controls movement, e.g., controlling speed, position, and/or timing, of the motorized stage along a first scan line to controllably scan a first portion of the specimen along the scan line. The user may then index the motorized stage from the first scan line to the next scan line and manually control movement of the stage along the second scan line to controllably scan another portion of the specimen. Stage indexing may also be automatic such that the user does not control or initiate indexing.

Claims (13)

1. A system for scanning a cytological specimen, comprising:

a motorized stage configured to support a cytological specimen slide;

a processor operatively coupled to the motorized stage; and

a scan controller operatively coupled to the processor,

the motorized stage, the processor, and the scan controller being configured such that manipulation of the scan controller provides

manual control of movement of the motorized stage along a first scan line to controllably scan a first portion of the cytological specimen slide along the first scan line, and

manual control of movement of the motorized stage along the second scan line to controllably scan a second portion of the cytological specimen slide along the second scan line, the processor and the scan controller being further configured such that the motorized stage is automatically indexed from the first scan line to the second scan line between manually controlled scans of the cytological specimen slide along the first and second scan lines,

wherein the scan controller is a coaxial controller comprising a first rotary control element that is rotatable, when enabled, to manually control movement of the motorized stage along the first and second scan lines, and a second rotary control element coaxial with the first rotary control element, the second rotary control element being rotatable, when enabled, to manually index the motorized stage, and

wherein the processor is configured to disable the second rotary control element during manual control of movement of the motorized stage.

2. The system of claim 1 , wherein the processor is configured to detect that the motorized stage has been manually positioned at an end of the first scan line and enable the second rotary control element when in a disabled state, the second rotary control element being rotatable to index the motorized stage from the first scan line to the second scan line.

3. The system of claim 1 , further comprising a review controller operatively coupled to the processor.

4. The system of claim 1 , wherein the scan controller comprises a review controller operatively coupled to the processor, the review controller including at least one button that can be pressed to manually index the motorized stage.

5. The system of claim 4 , wherein the review controller is configured to (i) temporarily suspend scanning of the cytological specimen at a current motorized stage position, and (ii) manually review a selected portion of the cytological specimen at another motorized stage position.

Assignments (10)
RELEASE OF SECURITY INTEREST Recorded Apr 28, 2026
From: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
To: HOLOGIC, INC., ON ITS OWN BEHALF AND AS SUCCESSOR-BY-MERGER TO DIRECT RADIOGRAPHY CORP.; CYTYC CORPORATION, ON ITS OWN BEHALF AND AS SUCCESSOR-BY-MERGER TO BIOLUCENT, LLC; CYTYC SURGICAL PRODUCTS, LLC, AS SUCCESSOR-BY-CONVERSION TO CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; GEN-PROBE INCORPORATED, ON ITS OWN BEHALF AND AS SUCCESSOR-BY-MERGER TO THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE PRODESSE, INC.; SUROS SURGICAL SYSTEMS, INC.
Reel/Frame 075566/0039 →
SECURITY INTEREST Recorded Apr 8, 2026
From: BIOTHERANOSTICS, INC.; GEN-PROBE INCORPORATED; GEN-PROBE PRODESSE, INC.; CYTYC CORPORATION; SUROS SURGICAL SYSTEMS, INC.; GYNESONICS, INC.; BOLDER SURGICAL, LLC; FAXITRON BIOPTICS, LLC; HEALTH BEACONS, INC.; HOLOGIC, INC.
To: ROYAL BANK OF CANADA, AS COLLATERAL AGENT
Reel/Frame 075462/0440 →
CORRECTIVE ASSIGNMENT TO CORRECT THE INCORRECT PATENT NO. 8081301 PREVIOUSLY RECORDED AT REEL: 028810 FRAME: 0745. ASSIGNOR(S) HEREBY CONFIRMS THE SECURITY AGREEMENT. Recorded Nov 9, 2017
From: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE INCORPORATED
To: GOLDMAN SACHS BANK USA
Reel/Frame 044432/0565 →
CORRECTIVE ASSIGNMENT TO CORRECT THE INCORRECT PATENT NO. 8081301 PREVIOUSLY RECORDED AT REEL: 035820 FRAME: 0239. ASSIGNOR(S) HEREBY CONFIRMS THE SECURITY INTEREST RELEASE. Recorded Nov 9, 2017
From: GOLDMAN SACHS BANK USA, AS COLLATERAL AGENT
To: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE INCORPORATED
Reel/Frame 044727/0529 →
SECURITY AGREEMENT Recorded Aug 7, 2015
From: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; DIRECT RADIOGRAPHY CORP.; GEN-PROBE INCORPORATED; GEN-PROBE PRODESSE, INC.; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.
To: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
Reel/Frame 036307/0199 →
SECURITY INTEREST RELEASE REEL/FRAME 028810/0745 Recorded Jun 4, 2015
From: GOLDMAN SACHS BANK USA, AS COLLATERAL AGENT
To: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE INCORPORATED
Reel/Frame 035820/0239 →
SECURITY AGREEMENT Recorded Aug 1, 2012
From: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE INCORPORATED
To: GOLDMAN SACHS BANK USA
Reel/Frame 028810/0745 →
TERMINATION OF PATENT SECURITY AGREEMENTS AND RELEASE OF SECURITY INTERESTS Recorded Aug 26, 2010
From: GOLDMAN SACHS CREDIT PARTNERS, L.P., AS COLLATERAL AGENT
To: HOLOGIC, INC.; R2 TECHNOLOGY, INC.; SUROS SURGICAL SYSTEMS, INC.; BIOLUCENT, LLC; DIRECT RADIOGRAPHY CORP.; CYTYC SURGICAL PRODUCTS II LIMITED PARTNERSHIP; CYTYC SURGICAL PRODUCTS LIMITED PARTNERSHIP; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS III, INC.; CYTYC PRENATAL PRODUCTS CORP.; THIRD WAVE TECHNOLOGIES, INC.
Reel/Frame 024892/0001 →
SIXTH SUPPLEMENT TO PATENT SECURITY AGREEMENT Recorded Jan 27, 2009
From: CYTYC CORPORATION
To: GOLDMAN SACHS CREDIT PARTNERS L.P., AS COLLATERAL AGENT
Reel/Frame 022163/0844 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 15, 2008
From: GUINEY, PATRICK; TENNEY, DOUGLAS A.
To: CYTYC CORPORATION
Reel/Frame 021981/0596 →