Granted Patent B2

US 8,357,395 · App. 12/336,812 · Granted Jan 22, 2013

Abstract

Claims (28)

1. A method of manufacturing a tablet comprising a pharmaceutically active agent, said method comprising the steps of:

(a) adding a powder comprising a pharmaceutically-acceptable carrier to a die cavity;

(b) injecting a liquid drug composition comprising said pharmaceutically active agent into said die cavity such that said liquid drug composition contacts said powder;

(c) adding additional powder comprising a pharmaceutically-acceptable carrier to a die cavity containing said liquid drug composition;

(d) compressing the combination of said powder and said liquid drug composition within said die cavity to form said tablet; and

(e) removing said tablet from said die cavity.

2. A method of claim 1 , wherein the concentration of said pharmaceutically active agent is less than about 5%, by weight, of said tablet.

3. A method of claim 1 , wherein the concentration of said pharmaceutically active agent is less than about 1%, by weight, of said tablet.

4. A method of claim 1 , wherein the concentration of said pharmaceutically active agent is less than about 0.1%, by weight, of said tablet.

5. A method of claim 1 , wherein said liquid drug composition further comprises a liquid carrier and said method further comprises the step of removing at least a portion of said liquid carrier from said tablet.

6. A method of claim 1 , wherein said liquid drug composition further comprises a liquid carrier and said method further comprises the step of removing substantially all of said liquid carrier from said tablet.

7. A method of claim 1 , wherein said liquid drug composition is a molten composition held above 37 degrees centigrade prior to said injection.

8. A method of claim 1 , wherein said liquid drug composition is a solution of said pharmaceutically active agent.

9. A method of claim 1 , wherein said liquid drug composition is a suspension of said pharmaceutically active agent, and the mean particle size of said pharmaceutically active agent is less than 100 microns.

10. A method of claim 1 , wherein the powder comprises a pharmaceutically active agent.

11. A method of claim 10 , wherein the powder comprises a different pharmaceutically active agent than the pharmaceutically active agent comprised within said liquid drug composition.

12. A method of claim 10 , wherein the powder comprises the same pharmaceutically active agent as is comprised within said liquid drug composition.

13. A method of claim 10 , wherein the pharmaceutically active agent comprised within said liquid drug composition is contained in a modified release coated particle.

14. A method of claim 1 , wherein said method further comprises coating said tablet.

15. A method of claim 1 , wherein said injection is delivered from a port within the die cavity.

16. A method of claim 1 , wherein said injection is delivered from a port above the die cavity.

17. A method of claim 1 , wherein said additional powder is different from said powder initially added to said die cavity.

18. A method of claim 1 wherein said liquid drug composition comprises a non-volatile liquid carrier and said powder comprises an adsorbent material.

19. A method of manufacturing a tablet comprising a pharmaceutically active agent, said method comprising the steps of:

(a) adding a powder to a die cavity;

(b) compressing said powder within said die cavity to form a tablet;

(c) injecting a liquid drug composition comprising said pharmaceutically active agent onto said tablet while said tablet is still within said die cavity; and

(d) removing said tablet from said die cavity.

Assignments (8)