Substituted 8-[6-amino-3pyridyl]xanthines
View Patent ↗The present invention provides substituted 8-[6-amino-3-pyridyl]xanthines like the compound shown in the following formula: and pharmaceutical compositions that are selective antagonists of A 2B adenosine receptors (ARs). These compounds and compositions are useful as pharmaceutical agents.
1. A compound selected from the group:
or a pharmaceutically acceptable salt thereof.
2. A pharmaceutical composition comprising:
(a) a therapeutically effective amount of a compound of claim 1 ; and
(b) a pharmaceutically acceptable excipient.
3. A method for treating asthma comprising administering an effective amount of a compound claim 1 to a mammal in need of such treatment.
4. A method for treating diarrhea, insulin resistance, and diabetic retinopathy, comprising administering an effective amount of a compound claim 1 or a pharmaceutically acceptable salt thereof to a mammal in need of such treatment.
5. A compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
6. A pharmaceutical composition comprising:
(a) a therapeutically effective amount of a compound of claim 5 ; and
(b) a pharmaceutically acceptable excipient.
7. A compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
8. A pharmaceutical composition comprising:
(a) a therapeutically effective amount of a compound of claim 7 ; and
(b) a pharmaceutically acceptable excipient.
9. A compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
10. A pharmaceutical composition comprising:
(a) a therapeutically effective amount of a compound of claim 9 ; and
(b) a pharmaceutically acceptable excipient.
11. A compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
12. A pharmaceutical composition comprising:
(a) a therapeutically effective amount of a compound of claim 11 ; and
(b) a pharmaceutically acceptable excipient.
13. A compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
14. A pharmaceutical composition comprising:
(a) a therapeutically effective amount of a compound of claim 13 ; and
(b) a pharmaceutically acceptable excipient.
15. A method for treating asthma, comprising administering an effective amount of a compound claim 5 to a mammal in need of such treatment.
16. A method for treating diarrhea, insulin resistance, and diabetic retinopathy, comprising administering an effective amount of a compound claim 5 or a pharmaceutically acceptable salt thereof to a mammal in need of such treatment.
17. A method for treating asthma, comprising administering an effective amount of a compound claim 7 to a mammal in need of such treatment.
18. A method for treating diarrhea, insulin resistance, and diabetic retinopathy, comprising administering an effective amount of a compound claim 7 or a pharmaceutically acceptable salt thereof to a mammal in need of such treatment.
19. A method for treating asthma, comprising administering an effective amount of a compound claim 9 to a mammal in need of such treatment.
20. A method for treating diarrhea, insulin resistance, and diabetic retinopathy, comprising administering an effective amount of a compound claim 9 or a pharmaceutically acceptable salt thereof to a mammal in need of such treatment.
21. A method for treating asthma, comprising administering an effective amount of a compound claim 11 to a mammal in need of such treatment.
22. A method for treating diarrhea, insulin resistance, and diabetic retinopathy, comprising administering an effective amount of a compound claim 11 or a pharmaceutically acceptable salt thereof to a mammal in need of such treatment.
23. A method for treating asthma, comprising administering an effective amount of a compound claim 13 to a mammal in need of such treatment.
24. A method for treating diarrhea, insulin resistance, and diabetic retinopathy, comprising administering an effective amount of a compound claim 13 or a pharmaceutically acceptable salt thereof to a mammal in need of such treatment.